How gallic acid regulates molecular signaling: role in cancer drug resistance.
Cancer
Drug resistance
Gallic acid
Molecular pathway
Journal
Medical oncology (Northwood, London, England)
ISSN: 1559-131X
Titre abrégé: Med Oncol
Pays: United States
ID NLM: 9435512
Informations de publication
Date de publication:
27 Sep 2023
27 Sep 2023
Historique:
received:
12
05
2023
accepted:
30
08
2023
medline:
30
10
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
epublish
Résumé
Cancer is one of the deadliest and most heterogeneous diseases. Cancers often develop drug resistance, which can lead to treatment failure or recurrence. Accordingly, anticancer compounds are essential for chemotherapy-resistant cancer cells. Phenolic compounds are of interest in the development of cancer drugs due to their medicinal properties and ability to target different molecular pathways. Gallic acid (GA), as one of the main components of phenol, which is abundantly present in plant compounds such as walnut, sumac, grapes, tea leaves, oak bark, and other plant compounds, has antitumor properties. GA can prevent cancer progression, cell invasion, and metastasis by targeting molecular pathways and is an effective complement to chemotherapy drugs and combating multidrug resistance (MDR). In this review, we discuss various mechanisms related to cancer, the therapeutic potential of GA, the antitumor properties of GA in various cancers, and the targeted delivery of GA with nanocarriers.
Identifiants
pubmed: 37755616
doi: 10.1007/s12032-023-02178-4
pii: 10.1007/s12032-023-02178-4
doi:
Substances chimiques
Gallic Acid
632XD903SP
Antineoplastic Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
308Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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