Oral and IV Varespladib Rescue Experiments in Juvenile Pigs with Weakness Induced by Australian and Papuan
Oxyuranus
antivenom
coastal taipan
direct toxin inhibitor
phospholipase A2 inhibitors
snakebite
varespladib
venom
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
07 09 2023
07 09 2023
Historique:
received:
08
06
2023
revised:
02
08
2023
accepted:
17
08
2023
medline:
28
9
2023
pubmed:
27
9
2023
entrez:
27
9
2023
Statut:
epublish
Résumé
Antivenom is currently the standard-of-care treatment for snakebite envenoming, but its efficacy is limited by treatment delays, availability, and in many cases, species specificity. Many of the rapidly lethal effects of envenoming are caused by venom-derived toxins, such as phospholipase A2 (sPLA2); therefore, small molecule direct toxin inhibitors targeting these toxins may have utility as initial and adjunct therapies after envenoming. Varespladib (intravenous, IV) and varespladib-methyl (oral) have been shown to potently inhibit sPLA2s from snake venoms in murine and porcine models, thus supporting their further study as potential treatments for snakebite envenoming. In this pilot study, we tested the ability of these compounds to reverse neurotoxic effects of venom from the Australian and Papuan taipan (
Identifiants
pubmed: 37755983
pii: toxins15090557
doi: 10.3390/toxins15090557
pmc: PMC10537020
pii:
doi:
Substances chimiques
varespladib
2Q3P98DATH
Antivenins
0
varespladib methyl
0NB98NBX3D
Elapid Venoms
0
Phospholipases A2, Secretory
EC 3.1.1.4
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : World Health Organization
ID : 001
Pays : International
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