Cycloartane-type triterpenoids and steroids from Trichilia connaroides and their multidrug resistance reversal activities.
Cycloartane-type triterpenoids
Meliaceae
Multidrug resistance reversal activities
Steroids
Trichilia connaroides
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
19
05
2023
revised:
04
09
2023
accepted:
17
09
2023
medline:
6
11
2023
pubmed:
28
9
2023
entrez:
27
9
2023
Statut:
ppublish
Résumé
Four undescribed cycloartane-type triterpenoids (1-4) and seven undescribed steroids (6-12), along with five known analogues (5 and 13-16), were isolated from the leaves of Trichilia connaroides. Their structures were identified based on the NMR data and HRESIMS, and the absolute configurations were determined through single-crystal X-ray diffraction analysis, Mosher's method, and ECD calculations. The multidrug resistance (MDR) reversal activities of all the isolates were assessed, and compounds 10 and 11 showed significant activities to reverse the MDR of MCF-7/DOX cells with IC
Identifiants
pubmed: 37757926
pii: S0031-9422(23)00283-2
doi: 10.1016/j.phytochem.2023.113867
pii:
doi:
Substances chimiques
cycloartane
511-64-8
Limonins
0
Triterpenes
0
Steroids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113867Informations de copyright
Copyright © 2023 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.