The structure of NAD

Acinetobacter baumannii / genetics Bacteria / metabolism Bacterial Proteins / metabolism Deuterium Hydrolases / metabolism Mammals / metabolism NAD / metabolism Protein Domains
bacterial pathogenesis hydrolase innate immunity nicotinamide adenine dinucleotide (NAD) toll/interleukin-1 receptor (TIR)

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
Nov 2023
Historique:
received: 25 05 2023
revised: 05 09 2023
accepted: 13 09 2023
medline: 27 11 2023
pubmed: 28 9 2023
entrez: 27 9 2023
Statut: ppublish

Résumé

Toll-like and interleukin-1/18 receptor/resistance (TIR) domain-containing proteins function as important signaling and immune regulatory molecules. TIR domain-containing proteins identified in eukaryotic and prokaryotic species also exhibit NAD+ hydrolase activity in select bacteria, plants, and mammalian cells. We report the crystal structure of the Acinetobacter baumannii TIR domain protein (AbTir-TIR) with confirmed NAD

Identifiants

DOI: 10.1016/j.jbc.2023.105290 PMID: 37758001 PMC: PMC10641520
pubmed: 37758001
pii: S0021-9258(23)02318-9
doi: 10.1016/j.jbc.2023.105290
pmc: PMC10641520
pii:
doi:

Substances chimiques

Bacterial Proteins 0
Deuterium AR09D82C7G
Hydrolases EC 3.-
NAD 0U46U6E8UK

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105290

Subventions

Organisme : NIGMS NIH HHS
ID : P30 GM133893
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM058264
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25 GM119970
Pays : United States
Organisme : NIGMS NIH HHS
ID : T34 GM150447
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI172487
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM146694
Pays : United States

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Erik Klontz (E)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.

Juliet O Obi (JO)

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.

Yajing Wang (Y)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA; Department of Physiology, School of Basic Medical Sciences and Clinical Pharmacy, China Pharmaceutical University, Nanjing, P.R. China.

Gabrielle Glendening (G)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.

Jahid Carr (J)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.

Constantine Tsibouris (C)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.

Sahthi Buddula (S)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.

Shreeram Nallar (S)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA; Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.

Alexei S Soares (AS)

Brookhaven National Laboratory, National Synchrotron Light Source II, Structural Biology Program, Upton, New York, USA.

Dorothy Beckett (D)

Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland, USA.

Jasmina S Redzic (JS)

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, School of Medicine, Aurora, Colorado, USA.

Elan Eisenmesser (E)

Department of Biochemistry and Molecular Genetics, School of Medicine, University of Colorado Denver, School of Medicine, Aurora, Colorado, USA.

Cheyenne Palm (C)

Department of Biological Sciences, Towson University, Towson, Maryland, USA.

Katrina Schmidt (K)

Department of Biological Sciences, Towson University, Towson, Maryland, USA.

Alexis H Scudder (AH)

Department of Biological Sciences, Towson University, Towson, Maryland, USA.

Trinity Obiorah (T)

Department of Biological Sciences, Towson University, Towson, Maryland, USA.

Kow Essuman (K)

Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA; Department of Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

Jeffrey Milbrandt (J)

Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA.

Aaron Diantonio (A)

Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA.

Krishanu Ray (K)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA; Department of Biochemistry and Molecular Biology at the University of Maryland, School of Medicine, Baltimore, Maryland, USA.

Michelle L D Snyder (MLD)

Department of Biological Sciences, Towson University, Towson, Maryland, USA.

Daniel Deredge (D)

Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, Maryland, USA.

Greg A Snyder (GA)

Division of Vaccine Research, Institute of Human Virology, School of Medicine, University of Maryland, Baltimore, Maryland, USA; Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, USA. Electronic address: gsnyder@ihv.umaryland.edu.

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Classifications MeSH

questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Moraxellaceae › Acinetobacter › Acinetobacter baumannii › The structure of NAD
questionsmedicales.fr › Bactéries › The structure of NAD
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › The structure of NAD
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Deutérium › The structure of NAD
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › The structure of NAD
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › The structure of NAD
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › The structure of NAD
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › The structure of NAD