5-Nitrofuran-Tagged Oxazolyl Pyrazolopiperidines: Synthesis and Activity against ESKAPE Pathogens.
5-nitrofuran derivatives
ESKAPE pathogens
antibacterial testing
flexible docking
nitroreductase
strained ligand–protein interactions
tetrahydropyrazolopyridine
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
07 Sep 2023
07 Sep 2023
Historique:
received:
28
07
2023
revised:
31
08
2023
accepted:
31
08
2023
medline:
4
10
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing of these compounds against pathogens of the ESKAPE panel showed a good activity of lead compound 1-(2-methoxyethyl)-5-(5-nitro-2-furoyl)-3-(1,3-oxazol-5-yl)-4,5,6,7-tetrahydro-1
Identifiants
pubmed: 37764267
pii: molecules28186491
doi: 10.3390/molecules28186491
pmc: PMC10537382
pii:
doi:
Substances chimiques
pyrazolopiperidine
0
Nitrofurans
0
Pyrazoles
0
Nitrofurantoin
927AH8112L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education and Science of Russia
ID : FSFZ-2023-0004
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