UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.
UDP-6 glucose dehydrogenase
UGDH
cancer
cancer biology
oncology
Journal
Oncotarget
ISSN: 1949-2553
Titre abrégé: Oncotarget
Pays: United States
ID NLM: 101532965
Informations de publication
Date de publication:
28 09 2023
28 09 2023
Historique:
medline:
2
10
2023
pubmed:
28
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors. In this review, we classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describe its involvement in key canonical cancer signaling pathways, and identify methods to inhibit UGDH, its substrates, and its downstream products. As such, we position UGDH as an enzyme to be exploited as a potential prognostication marker in oncology and a therapeutic target in cancer biology.
Identifiants
pubmed: 37769033
pii: 28514
doi: 10.18632/oncotarget.28514
pmc: PMC10538703
doi:
Substances chimiques
Uridine Diphosphate Glucose Dehydrogenase
EC 1.1.1.22
Uridine Diphosphate Glucose
V50K1D7P4Y
Glucose
IY9XDZ35W2
Glucose Dehydrogenases
EC 1.1.1.-
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
843-857Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE031053
Pays : United States
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