Photoluminescence detection of nadifloxacin: Adopts switching off photoinduced electron transfer (PET).

Electrons Electron Transport Fluoroquinolones Positron-Emission Tomography
Cream Nadifloxacin Pharmaceutical formulation Photoinduced electron transfer

Journal

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533

Informations de publication

Date de publication:
15 Jan 2024
Historique:
received: 18 08 2023
revised: 19 09 2023
accepted: 21 09 2023
medline: 8 11 2023
pubmed: 29 9 2023
entrez: 28 9 2023
Statut: ppublish

Résumé

A new fluorimetric sensing method for the selective and sensitive quantification of nadifloxacin (antibacterial agent, NDF) was established for the first time. The introduced method relies on blocking the photoinduced electron transfer (PET) effect of the nitrogen atom presented on the piperidine ring in NDF by fine-tuning the pH of the surrounding medium through its protonation using 0.5 M acetic acid. This protonation turns the weak fluorescence of NDF into stronger fluorescence intensity, allowing its selective and sensitive detection in its pure state as well as cream pharmaceutical formulation without any obstruction from the common excipients. The developed method has shown an NDF detection limit of 1.72 ng mL

Identifiants

DOI: 10.1016/j.saa.2023.123451 PMID: 37769466
pubmed: 37769466
pii: S1386-1425(23)01136-8
doi: 10.1016/j.saa.2023.123451
pii:
doi:

Substances chimiques

nadifloxacin 6CL9Y5YZEQ
Fluoroquinolones 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

123451

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Abobakr A Mohamed (AA)

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Fayoum University, 63514, Egypt.

Mahmoud A Omar (MA)

Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Medinah 42210, Saudi Arabia; Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61511, Egypt.

Sayed M Derayea (SM)

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61511, Egypt.

Mohamed Ahmed Elsayed (MA)

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Fayoum University, 63514, Egypt.

Islam M Mostafa (IM)

Analytical Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61511, Egypt; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China; University of Science and Technology of China, Hefei 230000, PR China. Electronic address: dr-islam@minia.edu.eg.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électrons › Photoluminescence detection of nadifloxacin:...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Transport d'électrons › Photoluminescence detection of nadifloxacin:...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinoléines › Quinolinone › Fluoroquinolones › Photoluminescence detection of nadifloxacin:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Photoluminescence detection of nadifloxacin:...