Aaptocarbamates A-G, chlorinated terpene carbamates with antiosteoclastogenic activities from the marine sponge Aaptos sp.

Aaptos sp. Antiosteoclastogenesis Chlorinated terpene carbamate Marine sponge Suberitidae

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Dec 2023
Historique:
received: 31 05 2023
revised: 19 09 2023
accepted: 22 09 2023
medline: 6 11 2023
pubmed: 29 9 2023
entrez: 28 9 2023
Statut: ppublish

Résumé

Six undescribed chlorinated sesquiterpene carbamates, aaptocarbamates A-F, and a chlorinated tris-norsesquiterpene carbamate, aaptocarbamate G, were isolated from the marine sponge Aaptos sp. collected in Indonesia. Aaptocarbamates D-F and G possess tetrahydrofurans and a tetrahydrofuranone, respectively. The relative configurations of the tetrahydrofuran units were determined by the NOE correlations and DFT-based calculation of the

Identifiants

pubmed: 37769957
pii: S0031-9422(23)00288-1
doi: 10.1016/j.phytochem.2023.113872
pii:
doi:

Substances chimiques

Terpenes 0
Carbamates 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113872

Informations de copyright

Copyright © 2023 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Ahmed H El-Desoky (AH)

Pharmaceutical and Drug Industries Research Institute, Pharmacognosy Department, National Research Centre, El-Tahrir St., Dokki, Giza, 12622, Egypt.

Keisuke Eguchi (K)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.

Ippei Kagiyama (I)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.

Yuki Hitora (Y)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.

Hikaru Kato (H)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan.

Yuji Ise (Y)

Kuroshio Biological Research Foundation, 560 Nishidomari, Otsuki, Hata, Kochi, 788-0333, Japan.

Fitje Losung (F)

Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado, 95115, Indonesia.

Remy E P Mangindaan (REP)

Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Bahu, Manado, 95115, Indonesia.

Sachiko Tsukamoto (S)

Department of Natural Medicines, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, 862-0973, Japan. Electronic address: sachiko@kumamoto-u.ac.jp.

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Classifications MeSH