Rhs NADase effectors and their immunity proteins are exchangeable mediators of inter-bacterial competition in Serratia.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
28 09 2023
28 09 2023
Historique:
received:
13
02
2023
accepted:
05
09
2023
medline:
23
10
2023
pubmed:
29
9
2023
entrez:
28
9
2023
Statut:
epublish
Résumé
Many bacterial species use Type VI secretion systems (T6SSs) to deliver anti-bacterial effector proteins into neighbouring bacterial cells, representing an important mechanism of inter-bacterial competition. Specific immunity proteins protect bacteria from the toxic action of their own effectors, whilst orphan immunity proteins without a cognate effector may provide protection against incoming effectors from non-self competitors. T6SS-dependent Rhs effectors contain a variable C-terminal toxin domain (CT), with the cognate immunity protein encoded immediately downstream of the effector. Here, we demonstrate that Rhs1 effectors from two strains of Serratia marcescens, the model strain Db10 and clinical isolate SJC1036, possess distinct CTs which both display NAD(P)
Identifiants
pubmed: 37770429
doi: 10.1038/s41467-023-41751-3
pii: 10.1038/s41467-023-41751-3
pmc: PMC10539506
doi:
Substances chimiques
NAD+ Nucleosidase
EC 3.2.2.5
Bacterial Proteins
0
Type VI Secretion Systems
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6061Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 215599/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104556/Z/14/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 220321/Z/20/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N013735/1
Pays : United Kingdom
Informations de copyright
© 2023. Springer Nature Limited.
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