In vitro antimycobacterial activity and interaction profiles of diarylthiourea-copper (II) complexes with antitubercular drugs against Mycobacterium tuberculosis isolates.
Drug-resistant
Mycobacterium tuberculosis
Non-tuberculous mycobacteria
Synergism
Thiourea copper (II) complexes
Two-drug combination
Journal
Tuberculosis (Edinburgh, Scotland)
ISSN: 1873-281X
Titre abrégé: Tuberculosis (Edinb)
Pays: Scotland
ID NLM: 100971555
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
04
07
2023
revised:
19
09
2023
accepted:
23
09
2023
medline:
4
12
2023
pubmed:
30
9
2023
entrez:
29
9
2023
Statut:
ppublish
Résumé
The activity of several halogenated copper (II) complexes of 4-chloro-3-nitrophenylthiourea derivatives has been tested against Mycobacterium tuberculosis strains and strains of non-tuberculous mycobacteria. The compounds were 2-16 times more potent than current TB-drugs against multidrug-resistant M. tuberculosis 210. The 3,4-dichlorophenylthiourea complex (5) was equipotent to ethambutol (EMB) towards M. tuberculosis H
Identifiants
pubmed: 37774599
pii: S1472-9792(23)00110-5
doi: 10.1016/j.tube.2023.102412
pii:
doi:
Substances chimiques
Antitubercular Agents
0
Copper
789U1901C5
Ethambutol
8G167061QZ
Isoniazid
V83O1VOZ8L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102412Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.