Copper-containing titanium alloys promote the coupling of osteogenesis and angiogenesis by releasing copper ions.

Osteogenesis Titanium / pharmacology Copper / pharmacology Endothelial Cells Alloys / pharmacology Ions
Angiogenesis Bone regeneration Copper Coupling Osteogenesis

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
12 11 2023
Historique:
received: 28 07 2023
revised: 11 09 2023
accepted: 23 09 2023
medline: 13 10 2023
pubmed: 1 10 2023
entrez: 30 9 2023
Statut: ppublish

Résumé

Previous investigations have reported on the ability of copper (Cu)-bearing biomaterials to accelerate vascular formation and bone regeneration. However, few studies have explored the effects of Cu-bearing materials on the interactions between angiogenesis and osteogenesis. Therefore, in this study, we prepared Cu-containing alloys using selective laser melting (SLM) technology and investigated the impact of preosteoblasts seeded on Ti6Al4V-4.5Cu alloy on angiogenesis. Our results indicated that Ti6Al4V-4.5Cu alloys increased the expression of proangiogenic genes and proteins in preosteoblasts, which further stimulated vascular formation in endothelial cells. Besides, we discovered that the biological effects of the Ti6Al4V-4.5Cu alloy were partly attributed to the release of Cu ions. In short, our research demonstrated the ability of Ti6Al4V-4.5Cu alloys to promote the coupling of angiogenesis and osteogenesis by releasing Cu ions.

Identifiants

DOI: 10.1016/j.bbrc.2023.09.072 PMID: 37776747
pubmed: 37776747
pii: S0006-291X(23)01108-7
doi: 10.1016/j.bbrc.2023.09.072
pii:
doi:

Substances chimiques

titanium alloy (TiAl6V4) 12743-70-3
Titanium D1JT611TNE
Copper 789U1901C5
Alloys 0
Ions 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

157-164

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yanxi Li reports financial support was provided by Beijing Stomatological Hospital, Funds of Scientific and Technological Plan of Fujian Province and National Natural Science Foundation of China

Auteurs

Yanxi Li (Y)

Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, 100050, China.

Wenqiong Luo (W)

The First People's Hospital of Liangshan Yi Autonomous Prefecture, Sichuan, 615000, China.

Yuqi Liu (Y)

Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, 100050, China.

Yanjin Lu (Y)

Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, 350002, China.

Wei Geng (W)

Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, 100050, China. Electronic address: gengwei717@163.com.

Jinxin Lin (J)

Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian, 350002, China. Electronic address: franklin@fjirsm.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Développement locomoteur › Biominéralisation › Développement osseux › Ostéogenèse › Copper-containing titanium alloys promote the...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Titane › Copper-containing titanium alloys promote the...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Cuivre › Copper-containing titanium alloys promote the...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Copper-containing titanium alloys promote the...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Alliages › Copper-containing titanium alloys promote the...
questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Copper-containing titanium alloys promote the...