Genetic contributions to brain serotonin transporter levels in healthy adults.

Humans Adult Serotonin Plasma Membrane Transport Proteins / genetics Serotonin Tomography, X-Ray Computed Brain / diagnostic imaging Mesencephalon / metabolism Positron-Emission Tomography Neocortex / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 09 2023
Historique:
received: 28 03 2023
accepted: 27 09 2023
medline: 4 10 2023
pubmed: 1 10 2023
entrez: 30 9 2023
Statut: epublish

Résumé

The serotonin transporter (5-HTT) critically shapes serotonin neurotransmission by regulating extracellular brain serotonin levels; it remains unclear to what extent 5-HTT levels in the human brain are genetically determined. Here we applied [

Identifiants

DOI: 10.1038/s41598-023-43690-x PMID: 37777558 PMC: PMC10542378
pubmed: 37777558
doi: 10.1038/s41598-023-43690-x
pii: 10.1038/s41598-023-43690-x
pmc: PMC10542378
doi:

Substances chimiques

Serotonin Plasma Membrane Transport Proteins 0
Serotonin 333DO1RDJY
SLC6A4 protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

16426

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Silvia Elisabetta Portis Bruzzone (SEP)

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Arafat Nasser (A)

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Sagar Sanjay Aripaka (SS)

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Marie Spies (M)

Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.

Brice Ozenne (B)

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.

Peter Steen Jensen (PS)

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Gitte Moos Knudsen (GM)

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Vibe Gedsoe Frokjaer (VG)

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Psychiatric Centre Copenhagen, Copenhagen, Denmark.

Patrick MacDonald Fisher (PM)

Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. patrick.fisher@nru.dk.
Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark. patrick.fisher@nru.dk.

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questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genetic contributions to brain serotonin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de la sérotonine › Genetic contributions to brain serotonin...
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Autacoïdes › Sérotonine › Genetic contributions to brain serotonin...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Genetic contributions to brain serotonin...
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questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Genetic contributions to brain serotonin...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › Genetic contributions to brain serotonin...
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