The oxidoreductase activity of Rnf balances redox cofactors during fermentation of glucose to propionate in Prevotella.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 09 2023
30 09 2023
Historique:
received:
28
06
2023
accepted:
21
09
2023
medline:
4
10
2023
pubmed:
1
10
2023
entrez:
30
9
2023
Statut:
epublish
Résumé
Propionate is a microbial metabolite formed in the gastrointestinal tract, and it affects host physiology as a source of energy and signaling molecule. Despite the importance of propionate, the biochemical pathways responsible for its formation are not clear in all microbes. For the succinate pathway used during fermentation, a key enzyme appears to be missing-one that oxidizes ferredoxin and reduces NAD. Here we show that Rnf [ferredoxin-NAD
Identifiants
pubmed: 37777597
doi: 10.1038/s41598-023-43282-9
pii: 10.1038/s41598-023-43282-9
pmc: PMC10542786
doi:
Substances chimiques
Ferredoxins
0
Propionates
0
NAD
0U46U6E8UK
Glucose
IY9XDZ35W2
Oxidoreductases
EC 1.-
Succinates
0
Succinic Acid
AB6MNQ6J6L
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
16429Informations de copyright
© 2023. Springer Nature Limited.
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