Progress and prospect: Biosynthesis of plant natural products based on plant chassis.

Biological Products / metabolism Plants / metabolism Synthetic Biology
Hairy roots Heterologous expression Natural products Secondary metabolites Synthetic biology

Journal

Biotechnology advances
ISSN: 1873-1899
Titre abrégé: Biotechnol Adv
Pays: England
ID NLM: 8403708

Informations de publication

Date de publication:
12 2023
Historique:
received: 13 06 2023
revised: 24 09 2023
accepted: 26 09 2023
medline: 20 11 2023
pubmed: 2 10 2023
entrez: 1 10 2023
Statut: ppublish

Résumé

Plant-derived natural products are a specific class of active substances with numerous applications in the medical, energy, and industrial fields. Many of these substances are in high demand and have become the fundamental materials for various purposes. Recently, the use of synthetic biology to produce plant-derived natural products has become a significant trend. Plant chassis, in particular, offer unique advantages over microbial chassis in terms of cell structure, product affinity, safety, and storage. The development of the plant hairy root tissue culture system has accelerated the commercialization and industrialization of synthetic biology in the production of plant-derived natural products. This paper will present recent progress in the synthesis of various plant natural products using plant chassis, organized by the types of different structures. Additionally, we will summarize the four primary types of plant chassis used for synthesizing natural products from plant sources and review the enabling technologies that have contributed to the development of synthetic biology in recent years. Finally, we will present the role of isolated and combined use of different optimization strategies in breaking the upper limit of natural product production in plant chassis. This review aims to provide practical references for synthetic biologists and highlight the great commercial potential of plant chassis biosynthesis, such as hairy roots.

Identifiants

DOI: 10.1016/j.biotechadv.2023.108266 PMID: 37778531
pubmed: 37778531
pii: S0734-9750(23)00173-8
doi: 10.1016/j.biotechadv.2023.108266
pii:
doi:

Substances chimiques

Biological Products 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

108266

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest There are no conflicts of interest to declare.

Auteurs

Junjie Lin (J)

College of Life Sciences and Medicine, Key Laboratory of Plant Secondary Metabolism and Regulation in Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Xue Yin (X)

Ministry of Education, Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Harbin 150040, China.

Youran Zeng (Y)

College of Life Sciences and Medicine, Key Laboratory of Plant Secondary Metabolism and Regulation in Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Xinyu Hong (X)

College of Life Sciences and Medicine, Key Laboratory of Plant Secondary Metabolism and Regulation in Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Shuncang Zhang (S)

College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, China.

Beimi Cui (B)

Institute of Molecular Plant Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.

Qinlong Zhu (Q)

College of Life Sciences, South China Agricultural University, Guangzhou 510642, China.

Zongsuo Liang (Z)

College of Life Sciences and Medicine, Key Laboratory of Plant Secondary Metabolism and Regulation in Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Zheyong Xue (Z)

Ministry of Education, Key Laboratory of Saline-alkali Vegetation Ecology Restoration, Northeast Forestry University, Harbin 150040, China.. Electronic address: zyxue@nefu.edu.cn.

Dongfeng Yang (D)

College of Life Sciences and Medicine, Key Laboratory of Plant Secondary Metabolism and Regulation in Zhejiang Province, Zhejiang Sci-Tech University, Hangzhou 310018, China; Shaoxing Biomedical Research Institute of Zhejiang Sci-Tech University Co., Ltd, Zhejiang Engineering Research Center for the Development Technology of Medicinal and Edible Homologous Health Food, Shaoxing 312075, China. Electronic address: yangdongfeng@zstu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Mélanges complexes › Produits biologiques › Progress and prospect: Biosynthesis of plant...
questionsmedicales.fr › Eucaryotes › Plantes › Progress and prospect: Biosynthesis of plant...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Biologie synthétique › Progress and prospect: Biosynthesis of plant...