Critical Review-A Tribute to Louis Brocq Lymphomatoid Papulosis, the Key in Exploring the Relationship of Parapsoriasis and Mycosis Fungoides.
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 Nov 2023
01 Nov 2023
Historique:
medline:
2
11
2023
pubmed:
2
10
2023
entrez:
2
10
2023
Statut:
ppublish
Résumé
Both parapsoriasis and LyP appear clinically as inflammatory dermatoses with a paradoxical link to cMF. A key element in addressing the relationship of parapsoriasis and MF were the results of the French and Dutch long-term registries tracking the emergence of lymphomas in the setting of LyP. Both cMF and cALCL emerged almost equally in these long-term studies. This ultimately supports that the stem cells in both cMF and cALCL are probably derived from a common stem cell shared by CD4+/CD8+ memory stem cells defining cMF and CD30+ stem cells defining cALCL. The discovery of inducible Skin Associated Lymphoid Tissue (iSALT) mesenchymal hubs incorporating Tregs, with their pleiotropic functions represents a paradigm shift and formed a translational tool in this analysis of the paradox. LyP can be recast as activated inhibitory lymphomatoid T-cell hubs derived from inducible iTregs in iSALT and the source of the common stem cell LyP line. iSALT Treg integrated mesenchymal hubs provided an emerging translational tool in redefining integrated lymphomatoid pathways. Brocq's complex scheme defining parapsoriasis as hybrid inflammatory dermatoses with a paradoxical link to cMF became a template to preserve parapsoriasis as a clinical diagnosis. Two major iSALT Treg generated inhibitory integrated lymphomatoid hubs emerged. The major CD30+TNF lymphomatoid hub has been linked to cALCL. Clinically defined chronic regressing and relapsing parapsoriasis with the histopathology of patch stage MF can be redefined as lymphomatoid parapsoriasis. This twin inhibited oncogenic memory based hub is defined by Treg modulated, CD4+/CD8+memory linked PD-1/DL-1 cytoxic complex and lichenoid histopathology.
Identifiants
pubmed: 37782018
doi: 10.1097/DAD.0000000000002546
pii: 00000372-990000000-00241
pmc: PMC10581442
doi:
Types de publication
Biography
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
753-761Informations de copyright
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The author declares no conflicts of interest.
Références
Brocq L. Les parapsoriasis. Ann Dermatol Syphilgr (Paris). 1902;35:315–322.
Shelley WB, Crissey JT. Jean-Lois Brocq In Classics In Clinical Dermatology: With Biographical Sketches. New York, NY: The Parthenon Publishing Group; 2003:303–316.
Cerroni L. The “parapsoriasis”: a riddle, wrapped in a mystery, inside an enigma. In: Cerroni L, ed. Skin Lymphoma: The Illustrated Guide. 5th ed. Oxford, UK: John Wiley & Sons Ltd; 2020:15–22.
Xavier JCC, Ocanha-Xavier JP, Marques MEA. Shall we exclude parapsoriasis from medical vocabulary?. J Cutan Pathol. 2021;48:833–836.
Bazin PAE Lecons sur le traitment des maladies chronique en general, affections de la peau en particulier . Paris: Adrein Delahaye.1870:436–438.
Sanchez JL, Ackerman BA. The patch stage mycosis fungoides: criteria for histologic diagnosis. Am J Dermatopathol. 1979;1:5–26.
Macaulay WL. Lymphomatoid papulosis: a continuing self-healing eruption, clinically benign-histologically malignant. Arch Dermatol. 1968;97:23–30.
Cordel N, Tressieres B, D'Incan M, et al. Frequency and risk factors for associated lymphomas in patients with lymphomatoid papulosis. Oncologist. 2016;21:76–83.
Melchers RC, Willemze R, Bekkenk MW, et al. Frequency and prognosis of associated malignancies in 504 patients with lymphomatoid papulosis. J Eur Acad Dermatol Venereol. 2020;34:260–266.
Streilin JW. Skin-associated lymphoid tissue (SALT): origins and functions. J Invest Dermatol. 1983;80(suppl l):12s–13s.
Ono S, Kabashima K. Novel insights into the role of immune cells in skin and inducible skin-associated lymphoid tissue (iSALT). Allergo J Int. 2015;24:170–179.
Rosenblum M. Skin-resident Tregs: a powerful multi-tasking force for immune balance and tissue renewals. Dermatol Focus. 2018;36:1–6.
Ali N, Rosenblum MD. Regulatory T cells in skin. Regul T Cell Skin Immunol. 2017;152:372–381.
Willemze R, Meyer CJLM, Van Vloten WA, et al. The clinical and histopathologic spectrum of lymphomatoid papulosis. Br J Dermatol. 1982;45:42–48.
Schwab U, Stein H, Gerdes J, et al. Production of a monoclonal antibody specific for Hodgkin and Sternberg–Reed cells of Hodgkin’s disease and a subset of normal lymphoid cells. Nature. 1982;299:65–67.
Stein H, Mason DY, Gerdes J, et al. The expression of the Hodgkin’s disease associated antigen Ki1in reactive and neoplastic lymphoid tissue: evidence that Reed–Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells. Blood. 1985;66:848–858.
Willemze R. Lymphomatoid papulosis: relationship to pityriasis lichenoides and malignant lymphoma. Parapsoriasis. Proceeding First International Parapsoriasis Symposium. Rochester, MN: Mayo Foundation. Edit. Muller SA; 1989:74–77.
Edinger JT, Clark BZ, Pucevich BE, et al. CD30 expression and proliferative fraction in nontransformed mycosis fungoides. Am J Surg Pathol. 2009;33:1860–1868.
Fauconneau A, Pham-Ledard A, Cappellen D, et al. Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides: a study of 66 cases. Br J Dermatol. 2015;172:1547–1554.
Kadin ME. Regulation of CD30 antigen expression and its potential significance for human disease. Am J Pathol. 2000;156:1479–1484.
Kogame T, Kabashima K, Egawa G. Putative immunological functions of inducible skin-associated lymphoid tissue in the context of mucosa associated lymphoid tissue. Front Immunol. 2021;12:733484.
Nicolas JF, Auger C, Dardenne M, et al. Do epidermal cells produce thymic hormones in vivo? An immunohistochemical study using anti-thymic hormone antibodies. Thymus. 1988-1989;12:187–201.
Rosa I, Marini M, Manetti M. Telocytes: an emerging component of stem cell niche microenvironment. J Histochem Cytochem. 2021;69:795–818.
Pittenger MF, Discher DE, Peault BM, et al. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med. 2019;4:22.
Zeiser R, Nguyen VH, Hou J-Z, et al. Early CD30 signaling is critical for adoptively transferred CD4+CD25+ regulatory T cells in prevention of acute graft-versus-host disease. Blood. 2007;109:2225–2233.
Michael M, Shimoni A, Nagler A. Regulatory T cells in allogeneic stem cell transplantation. Clin Dev Immunol. 2013;207:608951.
Campbell C, Rudensky A. Roles of regulatory T cells in tissue pathophysiology and metabolism. Cell Metab. 2020;31:18–25.
Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell. 2008;133:775–787.
Clark RA. Resident memory T cells in human health and disease. Sci Transl Med. 2015;7:269rv1.
Kumar BV, Connors T, Farber DL. Human T cell development, localization and function throughout life. Immunity. 2018;48:202–213.
Heimal J. In: TePas E, ed. The Adaptive Cellular Immune Response: T Cells and Cytokines. 2020. Available at: https:www.uptodate.com/contents/the-adaptive-cellular-immune-response-T-cells-and cytokines . Accessed June, 2021.
Cerroni L. Pseudolymphoma of the skin. Skin Lymphoma: The Illustrated Guide. 5th ed. Oxford, UK: John Wiley & Sons Ltd; 2020:475–562.
Gomez-Orbaneja J, Iglesias Diez L, Sánchez Lozano JL, et al. Lymphomatoid contact dermatitis A syndrome produced by epicutaneous hypersensitivity with clinical features and a histopathologic picture similar to that of mycosis fungoides. Contact Dermatitis. 1976;2:139–143.
Lambert WC, Everett MA. The nosology of parapsoriasis. J Am Acad Dermatol. 1981;5:373–395.
Juliusberg F. Ube die pityriasis lichenoides chronica (psoriasiform exanthema). Archiv für Dermatologie und Syphilis. 1899;50:359–374.
Fortson JS, Schroeter AL, Esterly NB. Cutaneous T-cell lymphoma (parapsoriasis en plaque): an association with pityriasis lichenoides et varioliformis acuta in young children. Arch Dermatol. 1990;126:1449–1453.
Ko JW, Seong JY, Suh KS, et al. Pityriasis lichenoides-like mycosis fungoides in children. Br J Dermatol. 2000;142:347–352.
Freitag S, Boccara O, Brousse N, et al. Mycosis fungoides following pityriasis lichenoides: an exceptional event or a potential evolution? Pediatr Blood Cancer. 2012;58:307.
Willemze R, Scheffer E. Clinical and histologic differentiation between lymphomatoid papulosis and pityriasis lichenoides. J Am Acad Dermatol. 1985;13:418–428.
Wood GS, Strickler JG, Abel EA, et al. Immunohistology of pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica. J Am Acad Dermatol. 1987;16:559–570.
Devergie A. Pityriasis rubra pilaris. Traite Pratique des Maladies de la Peau. In: Shelley WB, Crissey JT, eds. Classics in Clinical Dermatology. 2nd ed. Paris: The Parthenon Publishing Group; 2003:454.
Alikhan A, Griffin J, Nguyen N, et al. Pediatric follicular mucinosis: presentation, histopathology, molecular genetics, treatment, and outcomes over an 11-year period at the Mayo clinic. Pediatr Dermatol. 2013;30:192–198.
Zvulunov A, Shkalim V, Ben-Amitai D, et al. Clinical and histopathologic spectrum of alopecia mucinosa/follicular mucinosis and its natural history in children. J Am Acad Dermatol. 2012;67:1174–1181.
Kossard S, Rubel D. Folliculotropic T-cell lymphocytosis (mucin-poor follicular mucinosis). Australas J Dermatol. 2000;41:120–123.
Magro CM, Crowson AN. Folliculotropic T-cell lymphocytosis as a distinct form of pilotropic T-cell dyscrasia. Am J Clin Pathol. 2011;135:221–229.
Dore E, Swick BL, Link BK, et al. Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal. J Cutan Pathol. 2017;44:360–366.
Gerami P, Guitart J. Basaloid folliculolymphoid hyperplasia: a distinctive finding in follicular mycosis fungoides. J Cutan Pathol. 2007;34:29–32.
Pierard GE, Ackerman AB, Lapiere CM. Follicular lymphomatoid papulosis. Am J Dermatopathol. 1980;2:173–180.
Kempf W, Kazakov DV, Baumgartner HP, et al. Follicular lymphomatoid papulosis revisited: a study of 11 cases, with new histopathological findings. J Am Acad Dermatol. 2013;68:809–816.
Kossard S, White A, Killingsworth M. Basaloid folliculolymphoid hyperplasia with alopecia as an expression of mycosis fungoides (CTCL). J Cutan Pathol. 1995;22:466–471.
Habermann E. Uber die akut verlaufende, nekrotisierende unterart der pityriasis lichenoides: (pityriasis lichenoides et varioliformis acuta). Dermatology. 1925;45:42–48.
Marks R, Black MM, Jones EW. Pityriasis lichenoides: a reappraisal. Br J Dermatol. 1972;86:215–225.
Borra T, Custrin A, Saggini A, et al. Pityriasis lichenoides, atypical pityriasis lichenoides and related conditions: a study of 66 cases. Am J Surg Pathol. 2018;42:1101–1112.
Kempf W, Kazakov DV, Palmedo G, et al. Pityriasis lichenoides et varioliformis acuta with numerous CD30 + cells. A variant mimicking lymphomatoid papulosis and other cutaneous lymphomas, a clinicopathologic, immunohistochemical and molecular biological study of 13 cases. Am J Surg Pathol. 2012;36:1021–1029.
Vonderheid EC, Kadin M, Telang GH. Significance of CD30 expression by epidermotropic cells in lymphomatoid papulosis and lymphomatoid pityriasis lichenoides. Clin Res Dermatol Open Access. 2018;4:1–6.
Cerroni L. Mycosis fungoides. In: Cerroni L, ed. Skin Lymphoma: The Illustrated Guide. 5th ed. Oxford, UK: John Wiley & Sons Ltd; 2020:23–112.
Zayour M, Gilmore E, Heald P, et al. A distinct entity in the spectrum of the CD30 + cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution. Am J Dermatopathol. 2009;31:37–43.
Jeunon T, Assoni A, Verdolin A. Pseudocarcinomatous hyperplasia, squamous cell carcinoma, and keratoacanthoma associated to lymphomas of the skin and external mucous membranes: a case report and literature review. Am J Dermatopathol. 2020;42:662–672.
Kossard S. Keratoacanthoma, committed stem cells and neoplastic aberrant infundibulogenesis integral in formulating a conceptual model for an infundibulocystic pathway to squamous cell carcinoma. J Cutan Pathol. 2021;48:184–191.
Dequidt L, Franck N, Sanchez-Pena P, et al. Cutaneous lymphomas appearing during treatment with biologics: 44 cases from the French study group on cutaneous lymphomas and French pharmacovigilance database. Br J Dermatol. 2019;181:616–618.
Avitan-Hersh E, Dias-Polak D, Ramon M, et al. Follicular eruption with folliculotropic lymphocytic infiltrates associated with anti‐tumor necrosis factor alpha therapy: report and study of 3 cases. J Cutan Pathol. 2020;47:113–120.
Ferran M, Santamaria-Babi LF. Pathological mechanisms of skin homing T cells in atopic dermatitis. World Allergy Organ J. 2010;3:44–47.
Caproni M, Bianchi B, D'Elios MM, et al. In vivo relevance of CD30 in atopic dermatitis. Allergy. 1997;52:1063–1070.
Fletcher CL, Orchard GE, Hubbard V, et al. CD30 + cutaneous lymphoma in association with atopic eczema. Arch Dermatol. 2004;140:449–454.
Espinosa ML, Nguyen MT, Aguirre AS, et al. Progression of cutaneous T-cell lymphoma after dupilumab: case review of 7 patients. J Am Acad Dermatol. 2020;83:197–199.