The modern landscape of fertility, pregnancy, and parenthood in people with cystic fibrosis.
Journal
Current opinion in pulmonary medicine
ISSN: 1531-6971
Titre abrégé: Curr Opin Pulm Med
Pays: United States
ID NLM: 9503765
Informations de publication
Date de publication:
01 11 2023
01 11 2023
Historique:
pmc-release:
01
11
2024
medline:
2
11
2023
pubmed:
4
10
2023
entrez:
4
10
2023
Statut:
ppublish
Résumé
With improved long-term survival and the expanding availability of cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapies that treat the underlying genetic defect in cystic fibrosis, more people are interested in parenthood. Cystic fibrosis care centers and people with cystic fibrosis need more information to guide decisions related to parenting. Here we present currently available data on fertility, pregnancy, and parenthood in the modern era of cystic fibrosis care. Fertility may be improving in female individuals with cystic fibrosis with the use of CFTR modulator therapies, and there is an associated increase in annual pregnancies. Infertility in male individuals with cystic fibrosis remains approximately 97-98% and is unchanged with CFTR modulators in those already born with cystic fibrosis. As more female individuals with cystic fibrosis experience pregnancy, questions remain about the impact of pregnancy on their health and that of their child. Fortunately, there are multiple routes to becoming a parent; however, more work is needed to understand the impact of pregnancy and parenthood in the context of CF as some previous data suggests potential challenges to the health of parents with cystic fibrosis. We encourage cystic fibrosis care teams to have knowledge and resources available to support the reproductive goals of all individuals with cystic fibrosis.
Identifiants
pubmed: 37789771
doi: 10.1097/MCP.0000000000001009
pii: 00063198-202311000-00011
pmc: PMC10629848
mid: NIHMS1926774
doi:
Substances chimiques
Cystic Fibrosis Transmembrane Conductance Regulator
126880-72-6
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
595-602Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL161164
Pays : United States
Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
J Cyst Fibros. 2021 May;20(3):388-394
pubmed: 32917549
J Cyst Fibros. 2022 Jul;21(4):721-724
pubmed: 35422395
J Cyst Fibros. 2023 Oct 11;:
pubmed: 37833123
J Cyst Fibros. 2016 Jan;15(1):133-4
pubmed: 26698017
Am J Obstet Gynecol. 2017 Feb;216(2):129-134
pubmed: 27776920
Paediatr Respir Rev. 2015 Oct;16 Suppl 1:25-7
pubmed: 26410278
Arch Gynecol Obstet. 2022 Apr;305(4):805-824
pubmed: 34636983
J Cyst Fibros. 2020 Mar;19(2):e7-e8
pubmed: 31882306
Reproduction. 2011 Dec;142(6):759-78
pubmed: 21964828
Chest. 2000 Oct;118(4):1059-62
pubmed: 11035677
J Cyst Fibros. 2018 Nov;17(6):779-782
pubmed: 29866531
J Cyst Fibros. 2021 May;20(3):402-406
pubmed: 33762125
Pediatr Pulmonol. 2019 Aug;54(8):1225-1233
pubmed: 31066212
Fertil Steril. 1973 Jul;24(7):512-6
pubmed: 4715225
Contraception. 2020 Apr;101(4):231-236
pubmed: 31935384
J Cyst Fibros. 2006 Dec;5(4):215-21
pubmed: 16627013
Klin Padiatr. 2019 Sep;231(5):271-273
pubmed: 31408905
Urology. 2023 Sep;179:9-15
pubmed: 37380131
Pediatr Pulmonol. 2023 May;58(5):1527-1534
pubmed: 36808716
Hum Reprod. 1998 Aug;13(8):2092-7
pubmed: 9756275
Psychol Health Med. 2017 Jul;22(6):744-752
pubmed: 27654805
Sci Transl Med. 2019 Mar 27;11(485):
pubmed: 30918114
Eur Respir J. 2020 Feb 6;55(2):
pubmed: 31699837
J Cyst Fibros. 2021 May;20(3):399-401
pubmed: 33353860
Curr Opin Obstet Gynecol. 2013 Jun;25(3):167-72
pubmed: 23429570
Paediatr Respir Rev. 2019 Aug;31:18-20
pubmed: 30962151
BJOG. 2020 Dec;127(13):1696-1703
pubmed: 32683738
J Cyst Fibros. 2022 Jul;21(4):725-727
pubmed: 34952795
Ann Am Thorac Soc. 2013 Jun;10(3):213-9
pubmed: 23802817
Chest. 2003 Oct;124(4):1460-8
pubmed: 14555580
J Cyst Fibros. 2022 Jul;21(4):662-668
pubmed: 35181269
J Cyst Fibros. 2023 Mar 23;:
pubmed: 36966038
Lancet. 2019 Nov 23;394(10212):1940-1948
pubmed: 31679946
Transl Androl Urol. 2021 Mar;10(3):1467-1478
pubmed: 33850781
Clin Ther. 2023 Mar;45(3):278-289
pubmed: 36841738
J Cyst Fibros. 2023 Apr 5;:
pubmed: 37029015
Fertil Steril. 1986 Mar;45(3):425-6
pubmed: 3949044
BMJ Open Respir Res. 2022 Jun;9(1):
pubmed: 35710144
Contraception. 2015 Feb;91(2):150-6
pubmed: 25477272
BJOG. 2013 Feb;120(3):354-61
pubmed: 23145929
Chest. 2021 Dec;160(6):2051-2060
pubmed: 34284004
Mol Cell Endocrinol. 2006 May 16;250(1-2):106-13
pubmed: 16414184
J Cyst Fibros. 2014 Jan;13(1):69-73
pubmed: 24018176
Matern Child Health J. 2017 Apr;21(4):818-824
pubmed: 27531009
Endocrinology. 2008 Jun;149(6):2790-7
pubmed: 18325992
JAMA. 1996 Nov 27;276(20):1638
pubmed: 8922448
Ont Health Technol Assess Ser. 2006;6(18):1-63
pubmed: 23074488
Breathe (Sheff). 2022 Jun;18(2):220005
pubmed: 36337124
Asian J Androl. 2021 Mar-Apr;23(2):140-145
pubmed: 32930103
J Patient Exp. 2022 Feb 1;9:23743735221077527
pubmed: 35128042
J Cyst Fibros. 2021 May;20(3):397-398
pubmed: 33191130
Chest. 2000 Jul;118(1):85-91
pubmed: 10893364
J Cyst Fibros. 2015 May;14(3):398-402
pubmed: 25280785
N Engl J Med. 1968 Jul 11;279(2):65-9
pubmed: 5657013
J Cyst Fibros. 2019 Oct;18 Suppl 2:S105-S110
pubmed: 31679721
J Cyst Fibros. 2020 Jul;19(4):521-526
pubmed: 32151568
J Cyst Fibros. 2019 Jul;18(4):525-529
pubmed: 30366850
J Health Psychol. 2021 Jan;26(1):60-81
pubmed: 32431218
Chest. 2006 Mar;129(3):706-11
pubmed: 16537871
Fetal Diagn Ther. 2023;50(2):136-142
pubmed: 36996799
N Engl J Med. 2019 Nov 7;381(19):1809-1819
pubmed: 31697873
J Obstet Gynecol Neonatal Nurs. 2017 Jan - Feb;46(1):72-77
pubmed: 27875677
J Patient Exp. 2021 Apr 28;8:23743735211014049
pubmed: 34179443
J Matern Fetal Neonatal Med. 2017 Jan;30(1):4-7
pubmed: 26940249