Target-based discovery of a broad spectrum flukicide.

Ca2+ signaling parasite praziquantel transient receptor potential channel

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
22 Sep 2023
Historique:
medline: 4 10 2023
pubmed: 4 10 2023
entrez: 4 10 2023
Statut: epublish

Résumé

Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases - for example, the parasitic blood fluke infection, schistosomiasis - are treated with the drug praziquantel (PZQ). However, PZQ is ineffective against disease caused by liver flukes from the genus

Identifiants

DOI: 10.1101/2023.09.22.559026 PMID: 37790347 PMC: PMC10542552
pubmed: 37790347
doi: 10.1101/2023.09.22.559026
pmc: PMC10542552
pii:
doi:

Types de publication

Preprint

Langues

eng

Auteurs

Daniel J Sprague (DJ)

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Program in Chemical Biology, Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Sang-Kyu Park (SK)

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Svenja Gramberg (S)

BFS, Institute of Parasitology, Justus Liebig University Giessen, Schubertstr. 81, 35392, Giessen, Germany.

Lisa Bauer (L)

BFS, Institute of Parasitology, Justus Liebig University Giessen, Schubertstr. 81, 35392, Giessen, Germany.

Claudia M Rohr (CM)

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Evgeny G Chulkov (EG)

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Emery Smith (E)

UF Scripps Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, 33458, USA.

Louis Scampavia (L)

UF Scripps Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, 33458, USA.

Timothy P Spicer (TP)

UF Scripps Molecular Screening Center, Department of Molecular Medicine, UF Scripps Biomedical Research, Jupiter, FL, 33458, USA.

Simone Haeberlein (S)

BFS, Institute of Parasitology, Justus Liebig University Giessen, Schubertstr. 81, 35392, Giessen, Germany.

Jonathan S Marchant (JS)

Department of Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

Classifications MeSH