Simone Haeberlein

Affiliations

BFS, Institute of Parasitology, Justus-Liebig-Universität Gießen, Schubertstrasse 81, 35392, Gießen, Germany.

Publications (27)

Development of Biarylalkyl Carboxylic Acid Amides with Improved Anti-schistosomal Activity.

ChemMedChem

Avec: Alejandra M Peter Ventura , Simone Haeberlein , Kerstin Lange-Grünweller , Arnold Grünweller , Roland K Hartmann , Christoph G Grevelding , Martin Schlitzer

Targeting Kinases in

Frontiers in veterinary science

Avec: Carolin M Morawietz , Hicham Houhou , Oliver Puckelwaldt , Laura Hehr , Domenic Dreisbach , Annika Mokosch , Elke Roeb , Martin Roderfeld , Bernhard Spengler , Simone Haeberlein

Identification and characterisation of the tegument-expressed aldehyde dehydrogenase SmALDH_312 of Schistosoma mansoni, a target of disulfiram.

European journal of medicinal chemistry

Avec: Mandy Beutler , Julie Harnischfeger , Michael H W Weber , Steffen R Hahnel , Thomas Quack , Ariane Blohm , Monique E Ueberall , Thomas Timm , Günter Lochnit , Georg A Rennar , Tom L Gallinger , Hicham Houhou , Stefan Rahlfs , Franco H Falcone , Katja Becker , Martin Schlitzer , Simone Haeberlein , Peter Czermak , Denise Salzig , Christoph G Grevelding

Reference gene analysis and its use for kinase expression profiling in Fasciola hepatica.

Scientific reports

Avec: Hicham Houhou , Oliver Puckelwaldt , Christina Strube , Simone Haeberlein

The ABL kinase inhibitor imatinib causes phenotypic changes and lethality in adult Schistosoma japonicum.

Parasitology research

Avec: Xuesong Li , Simone Haeberlein , Lu Zhao , Mudassar N Mughal , Tao Zhu , Lu Liu , Rui Fang , Yanqin Zhou , Junlong Zhao , Christoph G Grevelding , Min Hu

Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni.

PLoS neglected tropical diseases

Avec: Josina Kellershohn , Laura Thomas , Steffen R Hahnel , Arnold Grünweller , Roland K Hartmann , Martin Hardt , Andreas Vilcinskas , Christoph G Grevelding , Simone Haeberlein

Synthesis and antischistosomal activity of linker- and thiophene-modified biaryl alkyl carboxylic acid derivatives.

Archiv der Pharmazie

Avec: Alejandra M Peter Ventura , Simone Haeberlein , Leonie Konopka , Wiebke Obermann , Arnold Grünweller , Christoph G Grevelding , Martin Schlitzer

Spatial transcriptomics of a parasitic flatworm provides a molecular map of drug targets and drug resistance genes.

Nature communications

Avec: Svenja Gramberg , Oliver Puckelwaldt , Tobias Schmitt , Zhigang Lu , Simone Haeberlein

Anthelminthic Activity of Assassin Bug Venom against the Blood Fluke

Antibiotics (Basel, Switzerland)

Avec: Miray Tonk , Andreas Vilcinskas , Christoph G Grevelding , Simone Haeberlein

The anticancer drug imatinib induces autophagy in Schistosoma mansoni.

International journal for parasitology

Avec: Mudassar N Mughal , Christoph G Grevelding , Simone Haeberlein

Drug Repurposing and De Novo Drug Discovery of Protein Kinase Inhibitors as New Drugs against Schistosomiasis.

Molecules (Basel, Switzerland)

Avec: Bernardo Pereira Moreira , Michael H W Weber , Simone Haeberlein , Annika S Mokosch , Bernhard Spengler , Christoph G Grevelding , Franco H Falcone

Defining an optimal control for RNAi experiments with adult Schistosoma mansoni.

Scientific reports

Avec: Max F Moescheid , Oliver Puckelwaldt , Mandy Beutler , Simone Haeberlein , Christoph G Grevelding

Hepatocyte integrity depends on c-Jun-controlled proliferation in Schistosoma mansoni infected mice.

Scientific reports

Avec: Lukas Härle , Verena von Bülow , Lukas Knedla , Frederik Stettler , Heike Müller , Daniel Zahner , Simone Haeberlein , Anita Windhorst , Annette Tschuschner , Monika Burg-Roderfeld , Kernt Köhler , Christoph G Grevelding , Elke Roeb , Martin Roderfeld

Towards deorphanizing G protein-coupled receptors of

Parasitology

Avec: Oliver Weth , Simone Haeberlein , Martin Haimann , Yinjie Zhang , Christoph G Grevelding

First In Silico Screening of Insect Molecules for Identification of Novel Anti-Parasitic Compounds.

Pharmaceuticals (Basel, Switzerland)

Avec: Tom L Gallinger , Samuel Y Aboagye , Wiebke Obermann , Michael Weiss , Arnold Grünweller , Carlo Unverzagt , David L Williams , Martin Schlitzer , Simone Haeberlein

Target-based discovery of a broad spectrum flukicide.

bioRxiv : the preprint server for biology

Avec: Daniel J Sprague , Sang-Kyu Park , Svenja Gramberg , Lisa Bauer , Claudia M Rohr , Evgeny G Chulkov , Emery Smith , Louis Scampavia , Timothy P Spicer , Simone Haeberlein , Jonathan S Marchant

From dithiocarbamates to branched dithiocarbazates: Compounds with potent antischistosomal activity.

Archiv der Pharmazie

Avec: Tom L Gallinger , Wiebke Obermann , Kerstin Lange-Grünweller , Nina Schmidt , Simone Haeberlein , Arnold Grünweller , Christoph G Grevelding , Martin Schlitzer

Molecular characterization of Sm

Frontiers in cellular and infection microbiology

Avec: Xuesong Li , Oliver Weth , Simone Haeberlein , Christoph G Grevelding

Identification of a new panel of reference genes to study pairing-dependent gene expression in Schistosoma mansoni.

International journal for parasitology

Avec: Simone Haeberlein , Alexandra Angrisano , Thomas Quack , Zhigang Lu , Josina Kellershohn , Ariane Blohm , Christoph G Grevelding , Steffen R Hahnel

High-resolution AP-SMALDI MSI as a tool for drug imaging in Schistosoma mansoni.

Analytical and bioanalytical chemistry

Avec: Annika S Mokosch , Stefanie Gerbig , Christoph G Grevelding , Simone Haeberlein , Bernhard Spengler

First insights into the autophagy machinery of adult Schistosoma mansoni.

International journal for parasitology

Avec: Mudassar N Mughal , Christoph G Grevelding , Simone Haeberlein

Spatial visualization of drug uptake and distribution in Fasciola hepatica using high-resolution AP-SMALDI mass spectrometry imaging.

Parasitology research

Avec: Carolin M Morawietz , Alejandra M Peter Ventura , Christoph G Grevelding , Simone Haeberlein , Bernhard Spengler

Disulfiram and dithiocarbamate analogues demonstrate promising antischistosomal effects.

European journal of medicinal chemistry

Avec: Georg A Rennar , Tom L Gallinger , Patrick Mäder , Kerstin Lange-Grünweller , Simone Haeberlein , Arnold Grünweller , Christoph G Grevelding , Martin Schlitzer

Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates.

Scientific reports

Avec: Wiebke Obermann , Mohammad Farhan Darin Azri , Leonie Konopka , Nina Schmidt , Francesca Magari , Julian Sherman , Liliana M R Silva , Carlos Hermosilla , Andreas H Ludewig , Hicham Houhou , Simone Haeberlein , Mona Yiting Luo , Irina Häcker , Marc F Schetelig , Christoph G Grevelding , Frank C Schroeder , Gilbert Sei Kung Lau , Anja Taubert , Ana Rodriguez , Andreas Heine , Tiong Chia Yeo , Arnold Grünweller , Gaspar Taroncher-Oldenburg

Metabolic reprogramming of hepatocytes by

JHEP reports : innovation in hepatology

Avec: Verena von Bülow , Sarah Gindner , Anne Baier , Laura Hehr , Nicola Buss , Lena Russ , Sarah Wrobel , Victoria Wirth , Kuscha Tabatabai , Thomas Quack , Simone Haeberlein , Patrik Kadesch , Stefanie Gerbig , Katja R Wiedemann , Bernhard Spengler , Annabel Mehl , Gertrud Morlock , Gabriele Schramm , Jörn Pons-Kühnemann , Franco H Falcone , R Alan Wilson , Katrin Bankov , Peter Wild , Christoph G Grevelding , Elke Roeb , Martin Roderfeld

Target-based discovery of a broad-spectrum flukicide.

Nature structural & molecular biology

Avec: Daniel J Sprague , Sang-Kyu Park , Svenja Gramberg , Lisa Bauer , Claudia M Rohr , Evgeny G Chulkov , Emery Smith , Louis Scampavia , Timothy P Spicer , Simone Haeberlein , Jonathan S Marchant

Liver Fibrosis Is Enhanced by a Higher Egg Burden in Younger Mice Infected with

Cells

Avec: Heike Müller , Jan K Straßmann , Anne S Baier , Verena von Bülow , Frederik Stettler , Maximilian J Hagen , Fabian P Schmidt , Annette Tschuschner , Andreas R Schmid , Daniel Zahner , Kernt Köhler , Jörn Pons-Kühnemann , Daniel Leufkens , Dieter Glebe , Surmeet Kaur , Max F Möscheid , Simone Haeberlein , Christoph G Grevelding , Ralf Weiskirchen , Mohamed El-Kassas , Khaled Zalata , Elke Roeb , Martin Roderfeld

Réseau de co-auteurs

Christoph G Grevelding 21 collaborations

Arnold Grünweller 7 collaborations

Martin Schlitzer 6 collaborations

Bernhard Spengler 5 collaborations

Hicham Houhou 4 collaborations

Oliver Puckelwaldt 4 collaborations

Elke Roeb 4 collaborations

Martin Roderfeld 4 collaborations

Tom L Gallinger 4 collaborations

Wiebke Obermann 4 collaborations

Alejandra M Peter Ventura 3 collaborations

Kerstin Lange-Grünweller 3 collaborations

Steffen R Hahnel 3 collaborations

Thomas Quack 3 collaborations

Franco H Falcone 3 collaborations

Mudassar N Mughal 3 collaborations

Svenja Gramberg 3 collaborations

Verena von Bülow 3 collaborations

Roland K Hartmann 2 collaborations

Carolin M Morawietz 2 collaborations

Laura Hehr 2 collaborations

Mandy Beutler 2 collaborations

Michael H W Weber 2 collaborations

Ariane Blohm 2 collaborations

Georg A Rennar 2 collaborations

Xuesong Li 2 collaborations

Josina Kellershohn 2 collaborations

Andreas Vilcinskas 2 collaborations

Leonie Konopka 2 collaborations

Zhigang Lu 2 collaborations

Annika S Mokosch 2 collaborations

Frederik Stettler 2 collaborations

Heike Müller 2 collaborations

Daniel Zahner 2 collaborations

Annette Tschuschner 2 collaborations

Kernt Köhler 2 collaborations

Oliver Weth 2 collaborations

Daniel J Sprague 2 collaborations

Sang-Kyu Park 2 collaborations

Lisa Bauer 2 collaborations

Claudia M Rohr 2 collaborations

Evgeny G Chulkov 2 collaborations

Emery Smith 2 collaborations

Louis Scampavia 2 collaborations

Timothy P Spicer 2 collaborations

Jonathan S Marchant 2 collaborations

Nina Schmidt 2 collaborations

Stefanie Gerbig 2 collaborations

Jörn Pons-Kühnemann 2 collaborations

Domenic Dreisbach 1 collaboration

Annika Mokosch 1 collaboration

Julie Harnischfeger 1 collaboration

Monique E Ueberall 1 collaboration

Thomas Timm 1 collaboration

Günter Lochnit 1 collaboration

Stefan Rahlfs 1 collaboration

Katja Becker 1 collaboration

Peter Czermak 1 collaboration

Denise Salzig 1 collaboration

Christina Strube 1 collaboration

Lu Zhao 1 collaboration

Tao Zhu 1 collaboration

Lu Liu 1 collaboration

Rui Fang 1 collaboration

Yanqin Zhou 1 collaboration

Junlong Zhao 1 collaboration

Min Hu 1 collaboration

Laura Thomas 1 collaboration

Martin Hardt 1 collaboration

Tobias Schmitt 1 collaboration

Miray Tonk 1 collaboration

Bernardo Pereira Moreira 1 collaboration

Max F Moescheid 1 collaboration

Lukas Härle 1 collaboration

Lukas Knedla 1 collaboration

Anita Windhorst 1 collaboration

Monika Burg-Roderfeld 1 collaboration

Martin Haimann 1 collaboration

Yinjie Zhang 1 collaboration

Samuel Y Aboagye 1 collaboration

Michael Weiss 1 collaboration

Carlo Unverzagt 1 collaboration

David L Williams 1 collaboration

Alexandra Angrisano 1 collaboration

Patrick Mäder 1 collaboration

Mohammad Farhan Darin Azri 1 collaboration

Francesca Magari 1 collaboration

Julian Sherman 1 collaboration

Liliana M R Silva 1 collaboration

Carlos Hermosilla 1 collaboration

Andreas H Ludewig 1 collaboration

Mona Yiting Luo 1 collaboration

Irina Häcker 1 collaboration

Marc F Schetelig 1 collaboration

Frank C Schroeder 1 collaboration

Gilbert Sei Kung Lau 1 collaboration

Anja Taubert 1 collaboration

Ana Rodriguez 1 collaboration

Andreas Heine 1 collaboration

Tiong Chia Yeo 1 collaboration

Gaspar Taroncher-Oldenburg 1 collaboration

Sarah Gindner 1 collaboration

Anne Baier 1 collaboration

Nicola Buss 1 collaboration

Lena Russ 1 collaboration

Sarah Wrobel 1 collaboration

Victoria Wirth 1 collaboration

Kuscha Tabatabai 1 collaboration

Patrik Kadesch 1 collaboration

Katja R Wiedemann 1 collaboration

Annabel Mehl 1 collaboration

Gertrud Morlock 1 collaboration

Gabriele Schramm 1 collaboration

R Alan Wilson 1 collaboration

Katrin Bankov 1 collaboration

Peter Wild 1 collaboration

Jan K Straßmann 1 collaboration

Anne S Baier 1 collaboration

Maximilian J Hagen 1 collaboration

Fabian P Schmidt 1 collaboration

Andreas R Schmid 1 collaboration

Daniel Leufkens 1 collaboration

Dieter Glebe 1 collaboration

Surmeet Kaur 1 collaboration

Max F Möscheid 1 collaboration

Ralf Weiskirchen 1 collaboration

Mohamed El-Kassas 1 collaboration

Khaled Zalata 1 collaboration