D-to-E and T19V Variants of the pH-Low Insertion Peptide and Their Doxorubicin Conjugates Interact with Membrane at Higher pH Ranges Than WT.

Hydrogen-Ion Concentration Doxorubicin / chemistry Antineoplastic Agents Peptides / chemistry

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
17 10 2023
Historique:
medline: 23 10 2023
pubmed: 4 10 2023
entrez: 4 10 2023
Statut: ppublish

Résumé

To improve targeted cargo delivery to cancer cells, pH-Low Insertion Peptide (pHLIP) variants were developed to interact with the membrane at pH values higher than those of the WT. The Asp-to-Glu variants aim to increase side chain p

Identifiants

DOI: 10.1021/acs.biochem.3c00218 PMID: 37793002
pubmed: 37793002
doi: 10.1021/acs.biochem.3c00218
doi:

Substances chimiques

Doxorubicin 80168379AG
Antineoplastic Agents 0
Peptides 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2997-3011

Subventions

Organisme : NIGMS NIH HHS
ID : R15 GM128150
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125853
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM130207
Pays : United States

Auteurs

Faith W Wachira (FW)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Dancan C Githirwa (DC)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Thomas McPartlon (T)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Vladyslav Nazarenko (V)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Jerel J C Gonzales (JJC)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Makenzie M Gazura (MM)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Caitlin Leen (C)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Hannah R Clary (HR)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Claire Alston (C)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Lukas M Klees (LM)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.

Lan Yao (L)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.
Department of Physics, SUNY, Binghamton University, Binghamton, New York 13902, United States.

Ming An (M)

Department of Chemistry, State University of New York (SUNY), Binghamton University, Binghamton, New York 13902, United States.
ORCID: 0000-0002-6988-8058

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Patients' knowledge about renal secondary effects of anti-tumoral drugs and renal protection measures.

Pauline Corbaux, Matthieu Bainaud, Adrien Rousseau et al.
1.00
Humans Male Female Health Knowledge, Attitudes, Practice Middle Aged

Initial pH determines the morphological characteristics and secondary metabolite production in Aspergillus terreus and Streptomyces rimosus cocultures.

Tomasz Boruta, Martyna Foryś, Weronika Pawlikowska et al.
1.00
Aspergillus Hydrogen-Ion Concentration Coculture Techniques Secondary Metabolism Streptomyces rimosus

Scalp cooling therapy for chemotherapy-induced hair loss in patients with breast or gynecological cancers-an Asian tertiary institution experience.

Victor Guan Hui Lee, Jerold Loh, Fu Hui et al.
1.00
Humans Female Alopecia Breast Neoplasms Middle Aged

Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Concentration en ions d'hydrogène › D-to-E and T19V Variants of the pH-Low...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › D-to-E and T19V Variants of the pH-Low...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › D-to-E and T19V Variants of the pH-Low...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › D-to-E and T19V Variants of the pH-Low...