Autophagy: Regulator of cell death.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
04 10 2023
04 10 2023
Historique:
received:
12
01
2023
accepted:
14
09
2023
revised:
05
09
2023
medline:
1
11
2023
pubmed:
5
10
2023
entrez:
4
10
2023
Statut:
epublish
Résumé
Autophagy is the process by which cells degrade and recycle proteins and organelles to maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but disruption of autophagy mechanisms or excessive autophagic flux usually leads to cell death. Despite recent progress in the study of the regulation and underlying molecular mechanisms of autophagy, numerous questions remain to be answered. How does autophagy regulate cell death? What are the fine-tuned regulatory mechanisms underlying autophagy-dependent cell death (ADCD) and autophagy-mediated cell death (AMCD)? In this article, we highlight the different roles of autophagy in cell death and discuss six of the main autophagy-related cell death modalities, with a focus on the metabolic changes caused by excessive endoplasmic reticulum-phagy (ER-phagy)-induced cell death and the role of mitophagy in autophagy-mediated ferroptosis. Finally, we discuss autophagy enhancement in the treatment of diseases and offer a new perspective based on the use of autophagy for different functional conversions (including the conversion of autophagy and that of different autophagy-mediated cell death modalities) for the clinical treatment of tumors.
Identifiants
pubmed: 37794028
doi: 10.1038/s41419-023-06154-8
pii: 10.1038/s41419-023-06154-8
pmc: PMC10551038
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
648Informations de copyright
© 2023. The Author(s).
Références
Cell Host Microbe. 2015 Aug 12;18(2):221-32
pubmed: 26269957
Nat Commun. 2015 Aug 27;6:8048
pubmed: 26310906
J Cell Biol. 2020 Jul 6;219(7):
pubmed: 32437499
FEBS Lett. 1993 Oct 25;333(1-2):169-74
pubmed: 8224160
Cancer Discov. 2022 Sep 2;12(9):2180-2197
pubmed: 35771492
Cancer Lett. 2018 Mar 1;416:124-137
pubmed: 29274359
Blood. 2016 Oct 13;128(15):1944-1958
pubmed: 27540013
Cell Death Dis. 2018 Aug 29;9(9):875
pubmed: 30158521
J Med Chem. 2018 Jun 14;61(11):4656-4687
pubmed: 29211480
Autophagy. 2022 Feb;18(2):283-292
pubmed: 34036900
Front Pharmacol. 2022 Jul 11;13:930958
pubmed: 35899120
Mol Cell. 2006 May 19;22(4):463-75
pubmed: 16713577
Mol Biol Cell. 2019 Apr 15;30(9):1098-1107
pubmed: 30811270
Nature. 2019 Mar;567(7746):118-122
pubmed: 30760928
Autophagy. 2016;12(2):273-86
pubmed: 26312549
EMBO Mol Med. 2017 Aug;9(8):1030-1051
pubmed: 28606997
Autophagy. 2020 Apr;16(4):600-614
pubmed: 31208283
Cell Death Differ. 2017 Sep;24(9):1598-1608
pubmed: 28574506
Nat Cell Biol. 2013 Oct;15(10):1206-1219
pubmed: 24056303
J Med Chem. 2012 Jun 28;55(12):5734-48
pubmed: 22646221
Science. 2015 Sep 25;349(6255):aaa5612
pubmed: 26404840
Medicina (Kaunas). 2021 Nov 04;57(11):
pubmed: 34833421
EMBO Rep. 2022 Aug 3;23(8):e55192
pubmed: 35758175
Dev Cell. 2021 Jul 12;56(13):1961-1975.e5
pubmed: 34107300
Autophagy. 2013 Sep;9(9):1270-85
pubmed: 23846383
Cancers (Basel). 2020 Jan 09;12(1):
pubmed: 31936571
J Cancer. 2019 Jul 10;10(18):4245-4255
pubmed: 31413743
Autophagy. 2018;14(10):1693-1709
pubmed: 29938581
Autophagy. 2022 May;18(5):1049-1061
pubmed: 34517786
EMBO J. 2020 Sep 1;39(17):e105696
pubmed: 32716134
Mol Neurodegener. 2017 Jan 25;12(1):11
pubmed: 28122627
Protein Cell. 2022 May;13(5):336-359
pubmed: 33417139
Cell Death Differ. 2018 Mar;25(4):784-796
pubmed: 29229994
Front Cell Dev Biol. 2023 Feb 23;11:1137870
pubmed: 36910139
Commun Biol. 2018 Nov 28;1:210
pubmed: 30511023
J Biol Chem. 2006 Oct 6;281(40):30299-304
pubmed: 16901900
Autophagy. 2023 Feb;19(2):379-387
pubmed: 35435793
J Biol Chem. 2019 May 17;294(20):8197-8217
pubmed: 30926605
Clin Cancer Res. 2018 Jun 1;24(11):2482-2490
pubmed: 29420223
Cell Res. 2016 Sep;26(9):1021-32
pubmed: 27514700
Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6483-95
pubmed: 20574010
Circ Res. 2007 Mar 30;100(6):914-22
pubmed: 17332429
Cell. 2008 Jan 11;132(1):27-42
pubmed: 18191218
Autophagy. 2016 Nov;12(11):2213-2229
pubmed: 27635674
Cell Rep. 2018 Dec 4;25(10):2878-2890.e4
pubmed: 30517873
Autophagy. 2020 May;16(5):932-945
pubmed: 31379249
Autophagy. 2021 Jul;17(7):1729-1752
pubmed: 32559118
Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3214-5
pubmed: 23412333
J Biol Chem. 2014 Oct 24;289(43):29519-30
pubmed: 25217637
Nat Cell Biol. 2011 Feb;13(2):132-41
pubmed: 21258367
Cell Death Dis. 2021 Sep 8;12(9):839
pubmed: 34497268
Basic Res Cardiol. 2020 Apr 4;115(3):29
pubmed: 32248306
Nature. 2014 May 1;509(7498):105-9
pubmed: 24695223
Cancer Cell. 2021 May 10;39(5):678-693.e11
pubmed: 33740421
Annu Rev Immunol. 2015;33:79-106
pubmed: 25493335
PLoS One. 2015 Mar 19;10(3):e0120819
pubmed: 25790376
Nat Rev Mol Cell Biol. 2018 Jun;19(6):349-364
pubmed: 29618831
Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):182-7
pubmed: 26677873
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):2996-3005
pubmed: 30718432
Curr Opin Cell Biol. 2018 Apr;51:58-64
pubmed: 29175614
J Neurochem. 2016 Oct;139 Suppl 1:198-215
pubmed: 26860955
Nature. 2015 Nov 5;527(7576):105-9
pubmed: 26524528
Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):966-71
pubmed: 23277556
Cancer Res. 1994 May 1;54(9):2419-23
pubmed: 8162590
Mol Brain. 2016 Mar 22;9:31
pubmed: 27000202
Virus Res. 2022 Jul 2;315:198778
pubmed: 35421435
Dev Cell. 2016 May 23;37(4):337-349
pubmed: 27219062
Cold Spring Harb Perspect Biol. 2013 Apr 01;5(4):a013227
pubmed: 23545422
Cell Death Differ. 2017 Jul;24(7):1288-1302
pubmed: 28574511
Cell Death Dis. 2019 Mar 15;10(4):255
pubmed: 30874538
Nature. 2015 Jun 18;522(7556):359-62
pubmed: 26040717
Cell Death Differ. 2013 Sep;20(9):1161-73
pubmed: 23744296
Science. 2011 May 20;332(6032):923-5
pubmed: 21596981
Nature. 2013 Feb 14;494(7436):201-6
pubmed: 23364696
J Exp Med. 1997 Apr 21;185(8):1481-6
pubmed: 9126928
Sci Adv. 2022 Feb 11;8(6):eabm6393
pubmed: 35138901
Nat Chem Biol. 2014 Feb;10(2):133-40
pubmed: 24316735
Neurochem Res. 2021 Sep;46(9):2485-2494
pubmed: 34212292
Curr Biol. 2009 Nov 3;19(20):1741-6
pubmed: 19818615
EMBO Rep. 2016 Nov;17(11):1552-1564
pubmed: 27670885
EMBO J. 2017 Jan 17;36(2):135-150
pubmed: 27753622
EMBO Rep. 2022 Jun 7;23(6):e54801
pubmed: 35417087
Cell. 2019 Jun 13;177(7):1682-1699
pubmed: 31199916
Mol Oncol. 2021 Aug;15(8):2084-2105
pubmed: 33675143
Autophagy. 2021 Jun;17(6):1349-1366
pubmed: 32397857
Autophagy. 2021 Sep;17(9):2432-2448
pubmed: 33111629
World J Gastroenterol. 2022 Jun 21;28(23):2569-2581
pubmed: 35949353
Cell Death Dis. 2022 Nov 23;13(11):988
pubmed: 36418320
Nature. 2022 Sep;609(7928):815-821
pubmed: 36071159
Cell Cycle. 2017;16(21):2003-2010
pubmed: 28933588
Autophagy. 2021 Dec;17(12):3992-4009
pubmed: 33779513
J Control Release. 2015 Feb 10;199:17-28
pubmed: 25499918
Int J Mol Sci. 2022 Jun 30;23(13):
pubmed: 35806307
J Clin Invest. 2020 Jun 1;130(6):2978-2991
pubmed: 32364533
J Pharmacol Exp Ther. 2016 Aug;358(2):282-93
pubmed: 27231155
Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175
pubmed: 29307831
Science. 2011 May 20;332(6032):966-70
pubmed: 21512002
Mol Cells. 2017 Sep 30;40(9):607-612
pubmed: 28927262
J Biol Chem. 2014 Apr 4;289(14):10211-22
pubmed: 24558044
Biochem Biophys Res Commun. 2022 Jan 22;589:247-253
pubmed: 34929448
Cell. 2019 May 16;177(5):1094-1107
pubmed: 31100266
Nat Cell Biol. 2014 Dec;16(12):1180-91
pubmed: 25402683
Front Endocrinol (Lausanne). 2022 Jul 14;13:930919
pubmed: 35909524
Cell Death Differ. 2011 Apr;18(4):571-80
pubmed: 21311563
Sci Rep. 2017 Feb 16;7:42014
pubmed: 28205624
Mol Cell. 2019 Jun 6;74(5):891-908.e10
pubmed: 31006537
Nature. 2013 Aug 22;500(7463):468-71
pubmed: 23863932
Circulation. 2018 Nov 13;138(20):2247-2262
pubmed: 29853517
Int J Mol Sci. 2023 Apr 30;24(9):
pubmed: 37175806
Cell Res. 2018 Mar;28(3):265-280
pubmed: 29219147
Nat Genet. 2009 Nov;41(11):1179-81
pubmed: 19838196
Cell Death Dis. 2013 Feb 21;4:e501
pubmed: 23429287
Nat Commun. 2022 Oct 23;13(1):6318
pubmed: 36274088
Cell Death Dis. 2017 Mar 30;8(3):e2716
pubmed: 28358377
PLoS Genet. 2020 Nov 30;16(11):e1009083
pubmed: 33253201
EMBO J. 2020 Jun 17;39(12):e103181
pubmed: 32368828
Chem Biol. 2015 Aug 20;22(8):1040-51
pubmed: 26235054
Cell Cycle. 2020 Nov;19(22):2960-2962
pubmed: 33112197
Nat Cell Biol. 2006 Oct;8(10):1124-32
pubmed: 16998475
Hepatology. 2019 Dec;70(6):2142-2155
pubmed: 31095752
Biochem Biophys Res Commun. 2016 Sep 16;478(2):838-44
pubmed: 27510639
Arthritis Rheumatol. 2014 Jan;66(1):40-8
pubmed: 24449574
Dev Cell. 2018 Mar 12;44(5):555-565.e3
pubmed: 29533771
Mol Biol Rep. 2023 Apr;50(4):3229-3239
pubmed: 36705792
Nature. 2013 Dec 12;504(7479):296-300
pubmed: 24305049
Redox Biol. 2022 Jul;53:102324
pubmed: 35533575
Carcinogenesis. 2016 Mar;37(3):233-44
pubmed: 26762228
Cell. 2018 Jun 28;174(1):88-101.e16
pubmed: 29909986
Proc Natl Acad Sci U S A. 2017 Sep 26;114(39):E8294-E8303
pubmed: 28904095
FEBS J. 2010 Apr;277(7):1618-38
pubmed: 20148966
Cell Discov. 2022 May 3;8(1):40
pubmed: 35504898
Nat Cell Biol. 2020 Feb;22(2):225-234
pubmed: 32029897
Cell Death Dis. 2019 Oct 28;10(11):822
pubmed: 31659150
Nature. 2020 May;581(7806):100-105
pubmed: 32376951
Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20364-71
pubmed: 24277826
Autophagy. 2013 Oct;9(10):1553-65
pubmed: 23939042
Oxid Med Cell Longev. 2021 Aug 5;2021:3843145
pubmed: 34394825
Cell Death Differ. 2019 Mar;26(4):605-616
pubmed: 30568239
Biochem Biophys Res Commun. 2019 Jan 22;508(4):997-1003
pubmed: 30545638
JAMA Oncol. 2019 Jul 01;5(7):993-998
pubmed: 31120501
Nat Chem Biol. 2012 Oct;8(10):831-8
pubmed: 22922758
Stem Cells. 2015 Oct;33(10):3052-64
pubmed: 26086870
Cell Death Discov. 2022 Feb 21;8(1):75
pubmed: 35190552
JCI Insight. 2020 Jan 16;5(1):
pubmed: 31941841
Autophagy. 2021 Nov;17(11):3424-3443
pubmed: 33461384
Nat Cell Biol. 2018 Oct;20(10):1110-1117
pubmed: 30224761
Autophagy. 2014;10(12):2269-78
pubmed: 25629932
Cells. 2020 Jun 20;9(6):
pubmed: 32575749
Nature. 2019 Nov;575(7784):688-692
pubmed: 31634900
JCI Insight. 2020 May 7;5(9):
pubmed: 32376803
Blood. 2007 Jul 1;110(1):125-32
pubmed: 17376890
Int J Biol Sci. 2020 Jan 1;16(1):74-84
pubmed: 31892847
Proc Natl Acad Sci U S A. 2022 Jun 28;119(26):e2121987119
pubmed: 35749365
Autophagy. 2023 Mar;19(3):945-956
pubmed: 35947500
Nat Commun. 2014;5:3056
pubmed: 24445999
Mol Cell. 2019 Jan 17;73(2):354-363.e3
pubmed: 30581146
Sci Adv. 2022 Sep 2;8(35):eabo1215
pubmed: 36044577
Mol Cell. 2011 Dec 9;44(5):698-709
pubmed: 22152474
Autophagy. 2021 May;17(5):1157-1169
pubmed: 32264736
J Cell Biol. 1965 Sep 1;26(3):857-84
pubmed: 19866685
Cell Death Dis. 2020 Sep 2;11(8):717
pubmed: 32879309
Nature. 2015 Jun 18;522(7556):354-8
pubmed: 26040720
Cell Chem Biol. 2020 Apr 16;27(4):420-435
pubmed: 32160513
Cancer Res. 2021 May 1;81(9):2289-2303
pubmed: 33685989
Exp Mol Med. 2020 Jun;52(6):921-930
pubmed: 32591647
J Biol Chem. 2019 Dec 27;294(52):20009-20023
pubmed: 31748416
Cell Death Differ. 2018 Mar;25(3):486-541
pubmed: 29362479
Cell Death Dis. 2019 May 29;10(6):419
pubmed: 31142734
Exp Cell Res. 1988 Jul;177(1):103-8
pubmed: 3391236
Autophagy. 2018;14(8):1359-1375
pubmed: 29962265
Biochem Biophys Res Commun. 2018 Sep 10;503(3):1550-1556
pubmed: 30031610
Ann Neurol. 2009 Sep;66(3):378-89
pubmed: 19551849
Nat Chem Biol. 2021 Jun;17(6):665-674
pubmed: 33686292
Cell. 2020 Mar 19;180(6):1160-1177.e20
pubmed: 32160526
Brain. 2014 May;137(Pt 5):1481-95
pubmed: 24574503
Phytomedicine. 2022 Nov;106:154411
pubmed: 36030746
Cells. 2022 Jan 13;11(2):
pubmed: 35053374
Semin Cancer Biol. 2020 Nov;66:89-100
pubmed: 30880243
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
Sci Adv. 2019 Sep 11;5(9):eaax1978
pubmed: 31535025
Oxid Med Cell Longev. 2018 May 8;2018:4701275
pubmed: 29854084
Nat Cell Biol. 2014 Jan;16(1):47-54
pubmed: 24316673
Autophagy. 2023 Jan;19(1):54-74
pubmed: 35403545
Autophagy. 2019 May;15(5):843-870
pubmed: 30653446
Oncotarget. 2017 Oct 16;8(54):93131-93148
pubmed: 29190983
Autophagy. 2021 Nov;17(11):3361-3374
pubmed: 33404288
Sci Adv. 2019 Jul 24;5(7):eaaw2238
pubmed: 31355331
J Biol Chem. 2012 Apr 6;287(15):12455-68
pubmed: 22362782