Tricuspid Valve Academic Research Consortium Definitions for Tricuspid Regurgitation and Trial Endpoints.

Humans Tricuspid Valve Insufficiency / diagnosis Tricuspid Valve / surgery Heart Valve Prosthesis Implantation / adverse effects Treatment Outcome Comorbidity Cardiac Catheterization / adverse effects Severity of Illness Index

Journal

The Annals of thoracic surgery

ISSN: 1552-6259

Titre abrégé: Ann Thorac Surg

Pays: Netherlands

ID NLM: 15030100R

Informations de publication

Date de publication:
11 2023

Historique:

accepted: 08 08 2023

medline: 1 11 2023

pubmed: 7 10 2023

entrez: 7 10 2023

Statut: ppublish

Résumé

Interest in the pathophysiology, etiology, management, and outcomes of patients with tricuspid regurgitation (TR) has grown in the wake of multiple natural history studies showing progressively worse outcomes associated with increasing TR severity, even after adjusting for multiple comorbidities. Historically, isolated tricuspid valve surgery has been associated with high in-hospital mortality rates, leading to the development of transcatheter treatment options. The aim of this first Tricuspid Valve Academic Research Consortium document is to standardize definitions of disease etiology and severity, as well as endpoints for trials that aim to address the gaps in our knowledge related to identification and management of patients with TR. Standardizing endpoints for trials should provide consistency and enable meaningful comparisons between clinical trials. A second Tricuspid Valve Academic Research Consortium document will focus on further defining trial endpoints and will discuss trial design options.

Identifiants

DOI: 10.1016/j.athoracsur.2023.09.018 PMID: 37804270

pubmed: 37804270

pii: S0003-4975(23)00969-4

doi: 10.1016/j.athoracsur.2023.09.018

pii:

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Pagination

908-932

Investigateurs

Suzanne Arnold (S)

Vinayak Bapat (V)

Natalia Berry (N)

Philipp Blanke (P)

Daniel Burkhoff (D)

Megan Coylewright (M)

Neal Duggal (N)

Benjamin Galper (B)

Isaac George (I)

Mayra Guerrero (M)

Nadira Hamid (N)

Vikrant Jagadeesan (V)

Susheel Kodali (S)

Mitch Krucoff (M)

Roberto Lang (R)

Mahesh Madhavan (M)

Vallerie McLaughin (V)

Roxana Mehran (R)

Francois Philippon (F)

Sanjum S Sethi (SS)

Matheus Simonato (M)

Robert Smith (R)

Nishtha Sodhi (N)

John Spertus (J)

Thomas J Stocker (TJ)

Gregg Stone (G)