Catheter-Related Bloodstream Infections among patients on maintenance haemodialysis: a cross-sectional study at a tertiary hospital in Ghana.
Catheter-related bloodstream infections
Central venous catheter
Haemodialysis
Journal
BMC infectious diseases
ISSN: 1471-2334
Titre abrégé: BMC Infect Dis
Pays: England
ID NLM: 100968551
Informations de publication
Date de publication:
07 Oct 2023
07 Oct 2023
Historique:
received:
01
05
2023
accepted:
04
09
2023
medline:
9
10
2023
pubmed:
8
10
2023
entrez:
7
10
2023
Statut:
epublish
Résumé
Catheter-Related Bloodstream Infections (CRBSIs) are notable complications among patients receiving maintenance haemodialysis. However, data on the prevalence of CRBSIs is lacking. This study was conducted to determine the prevalence and factors associated with CRBSIs among patients receiving haemodialysis in the renal unit of the largest tertiary hospital in Ghana. A hospital-based cross-sectional study was conducted on patients receiving maintenance haemodialysis via central venous catheters (CVC) between September 2021 and April 2022. Multivariate analysis using logistic regression was used to determine the risk factors that were predictive of CRBSI. Analysis was performed using SPSS version 23 and a p-value<0.05 was statistically significant. The prevalence of CRBSI was 34.2% (52/152). Of these, more than half of them (53.9%(28/52)) had Possible CRBSI while 11.5% (6/52) had Definite CRBSI. Among the positive cultures, 62% (21/34) were from catheter sites whilst the rest were from peripheral blood. Gram-negative cultures made up 53% (18/34) of positive cultures with the rest being Gram positive cultures. Acinetobacter baumannii (33.3% (6/18)) was the commonest organism isolated among Gram-negative cultures whilst Coagulase negative Staphylococci (43.7% (7/16)) was the commonest organism isolated among Gram-positve cultures. Gram-negative bacilli were more predominant in this study making up 52.9% of the total bacteria cultured. Sex, duration of maintenance dialysis, underlying cause of End-stage kidney disease, mean corpuscular haemoglobin (MCH), neutrophil count and lymphocyte count were significantly predictive of CRBSI status (p<0.05). There was a high prevalence of CRBSI among patients undergoing haemodialysis. The commonest causative agent was Coagulase negative Staphylococci, however there was a predominance of Gram-negative bacilli as compared to Gram positive cocci. There is a need to set up infection surveillance unit in the renal unit to track CRBSI and put in place measures to reduce these CRBSI.
Sections du résumé
BACKGROUND
BACKGROUND
Catheter-Related Bloodstream Infections (CRBSIs) are notable complications among patients receiving maintenance haemodialysis. However, data on the prevalence of CRBSIs is lacking. This study was conducted to determine the prevalence and factors associated with CRBSIs among patients receiving haemodialysis in the renal unit of the largest tertiary hospital in Ghana.
METHODS
METHODS
A hospital-based cross-sectional study was conducted on patients receiving maintenance haemodialysis via central venous catheters (CVC) between September 2021 and April 2022. Multivariate analysis using logistic regression was used to determine the risk factors that were predictive of CRBSI. Analysis was performed using SPSS version 23 and a p-value<0.05 was statistically significant.
RESULTS
RESULTS
The prevalence of CRBSI was 34.2% (52/152). Of these, more than half of them (53.9%(28/52)) had Possible CRBSI while 11.5% (6/52) had Definite CRBSI. Among the positive cultures, 62% (21/34) were from catheter sites whilst the rest were from peripheral blood. Gram-negative cultures made up 53% (18/34) of positive cultures with the rest being Gram positive cultures. Acinetobacter baumannii (33.3% (6/18)) was the commonest organism isolated among Gram-negative cultures whilst Coagulase negative Staphylococci (43.7% (7/16)) was the commonest organism isolated among Gram-positve cultures. Gram-negative bacilli were more predominant in this study making up 52.9% of the total bacteria cultured. Sex, duration of maintenance dialysis, underlying cause of End-stage kidney disease, mean corpuscular haemoglobin (MCH), neutrophil count and lymphocyte count were significantly predictive of CRBSI status (p<0.05).
CONCLUSION
CONCLUSIONS
There was a high prevalence of CRBSI among patients undergoing haemodialysis. The commonest causative agent was Coagulase negative Staphylococci, however there was a predominance of Gram-negative bacilli as compared to Gram positive cocci. There is a need to set up infection surveillance unit in the renal unit to track CRBSI and put in place measures to reduce these CRBSI.
Identifiants
pubmed: 37805461
doi: 10.1186/s12879-023-08581-6
pii: 10.1186/s12879-023-08581-6
pmc: PMC10559469
doi:
Substances chimiques
Coagulase
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
664Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Int J Nephrol Renovasc Dis. 2014 Jul 08;7:281-94
pubmed: 25045278
BMC Infect Dis. 2020 Aug 17;20(1):604
pubmed: 32807092
Am J Kidney Dis. 2013 Aug;62(2):322-30
pubmed: 23676763
Am J Kidney Dis. 2006 Jul;48 Suppl 1:S176-247
pubmed: 16813989
Kidney Int Suppl. 2003 Feb;(83):S119-22
pubmed: 12864889
Global Health. 2020 Jan 15;16(1):9
pubmed: 31941554
BMC Infect Dis. 2015 Jan 08;15:5
pubmed: 25566999
BMC Nephrol. 2019 Feb 26;20(1):68
pubmed: 30808313
Clin J Am Soc Nephrol. 2020 Jan 7;15(1):132-151
pubmed: 31806658
Clin J Am Soc Nephrol. 2018 Jan 6;13(1):175-181
pubmed: 28794000
Antimicrob Resist Infect Control. 2017 May 15;6:47
pubmed: 28515903
Kidney Int. 2006 Jan;69(2):375-82
pubmed: 16408129
Am J Infect Control. 2004 May;32(3):155-60
pubmed: 15153927
World J Nephrol. 2016 Nov 6;5(6):489-496
pubmed: 27872830
Saudi J Kidney Dis Transpl. 2016 May;27(3):569-75
pubmed: 27215252
Nephrol Dial Transplant. 2011 Mar;26(3):948-55
pubmed: 20702529
J Am Soc Nephrol. 2006 Aug;17(8):2275-84
pubmed: 16790511
Int Urol Nephrol. 2015 Oct;47(10):1727-34
pubmed: 26329742
Clin Kidney J. 2019 Feb 05;12(5):737-744
pubmed: 31583098
J Clin Med. 2022 Apr 17;11(8):
pubmed: 35456335
Am J Nephrol. 2019;50(2):126-132
pubmed: 31242483
BMC Public Health. 2017 Nov 23;17(1):896
pubmed: 29169340
J Vasc Interv Radiol. 2013 Sep;24(9):1289-94
pubmed: 23871694
Int J Nephrol. 2021 Jun 19;2021:5562690
pubmed: 34249377
Infect Drug Resist. 2021 Oct 01;14:4067-4075
pubmed: 34621127
Indian Pediatr. 2002 Aug;39(8):752-60
pubmed: 12196688
Kidney Int. 2000 Dec;58(6):2543-5
pubmed: 11115089
Int J Infect Dis. 2009 Sep;13(5):e241-7
pubmed: 19269873
Semin Dial. 2008 Jan-Feb;21(1):24-8
pubmed: 18251954
Hemodial Int. 2006 Oct;10(4):365-70
pubmed: 17014513
Clin Microbiol Infect. 2014 Oct;20(10):O627-9
pubmed: 24461043
Int J Crit Illn Inj Sci. 2014 Apr;4(2):162-7
pubmed: 25024944
Can J Kidney Health Dis. 2016 Sep 27;3:2054358116669129
pubmed: 28270921
Int J Med Sci. 2013 Sep 20;10(12):1632-8
pubmed: 24151435
Nephrol Dial Transplant. 2018 Oct 1;33(10):1812-1822
pubmed: 29342308
Front Endocrinol (Lausanne). 2021 Jul 01;12:672350
pubmed: 34276558
Int J Nephrol Renovasc Dis. 2016 Apr 18;9:95-103
pubmed: 27143948
Sci Rep. 2020 Feb 19;10(1):2938
pubmed: 32076027
Clin J Am Soc Nephrol. 2014 Apr;9(4):764-70
pubmed: 24651074