Free and Interfacial Boundaries in Individual-Based Models of Multicellular Biological systems.
Cell boundaries
Individual-based models
Tissue growth
Wound healing
Journal
Bulletin of mathematical biology
ISSN: 1522-9602
Titre abrégé: Bull Math Biol
Pays: United States
ID NLM: 0401404
Informations de publication
Date de publication:
08 10 2023
08 10 2023
Historique:
received:
05
06
2023
accepted:
11
09
2023
medline:
26
10
2023
pubmed:
8
10
2023
entrez:
8
10
2023
Statut:
epublish
Résumé
Coordination of cell behaviour is key to a myriad of biological processes including tissue morphogenesis, wound healing, and tumour growth. As such, individual-based computational models, which explicitly describe inter-cellular interactions, are commonly used to model collective cell dynamics. However, when using individual-based models, it is unclear how descriptions of cell boundaries affect overall population dynamics. In order to investigate this we define three cell boundary descriptions of varying complexities for each of three widely used off-lattice individual-based models: overlapping spheres, Voronoi tessellation, and vertex models. We apply our models to multiple biological scenarios to investigate how cell boundary description can influence tissue-scale behaviour. We find that the Voronoi tessellation model is most sensitive to changes in the cell boundary description with basic models being inappropriate in many cases. The timescale of tissue evolution when using an overlapping spheres model is coupled to the boundary description. The vertex model is demonstrated to be the most stable to changes in boundary description, though still exhibits timescale sensitivity. When using individual-based computational models one should carefully consider how cell boundaries are defined. To inform future work, we provide an exploration of common individual-based models and cell boundary descriptions in frequently studied biological scenarios and discuss their benefits and disadvantages.
Identifiants
pubmed: 37805982
doi: 10.1007/s11538-023-01214-8
pii: 10.1007/s11538-023-01214-8
pmc: PMC10560655
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111Informations de copyright
© 2023. The Author(s).
Références
J Math Biol. 2012 Sep;65(3):441-63
pubmed: 21898111
Prog Biophys Mol Biol. 2013 Nov;113(2):299-326
pubmed: 24120733
PLoS One. 2015 May 14;10(5):e0126484
pubmed: 25974182
Nat Phys. 2019;15:696-705
pubmed: 31897085
PLoS Comput Biol. 2013;9(3):e1002970
pubmed: 23516352
Nat Phys. 2014 Sep;10(9):683-690
pubmed: 27340423
PLoS Comput Biol. 2015 Dec 29;11(12):e1004679
pubmed: 26713738
Nat Commun. 2022 Jul 12;13(1):4026
pubmed: 35821232
PLoS Comput Biol. 2011 Jan 06;7(1):e1001045
pubmed: 21253562
Phys Biol. 2005 Jul 12;2(3):133-47
pubmed: 16224119
Int J Mol Sci. 2019 Feb 22;20(4):
pubmed: 30813239
Nat Phys. 2019 Jul 4;15(11):1195-1203
pubmed: 31700525
J Mech Behav Biomed Mater. 2013 Dec;28:397-409
pubmed: 23746929
Mol Cell Biol. 2011 Jan;31(2):342-50
pubmed: 20974808
Int J Numer Method Biomed Eng. 2017 Nov;33(11):
pubmed: 28249103
J Biomech Eng. 2000 Aug;122(4):394-401
pubmed: 11036563
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1995 Dec;52(6):6635-6657
pubmed: 9964180
Exp Eye Res. 2014 Jul;124:56-66
pubmed: 24810222
J Theor Biol. 2004 Nov 21;231(2):203-22
pubmed: 15380385
PLoS Comput Biol. 2020 Dec 23;16(12):e1008407
pubmed: 33362204
J Open Source Softw. 2020 Mar 13;5(47):1848
pubmed: 37192932
Cancer Manag Res. 2019 Jan 21;11:943-953
pubmed: 30718965
Cells. 2021 Feb 05;10(2):
pubmed: 33562816
Phys Biol. 2008 Apr 10;5(1):015002
pubmed: 18403827
Cell Syst. 2017 Feb 22;4(2):194-206.e9
pubmed: 28089542
Adv Drug Deliv Rev. 2019 Jun;146:344-365
pubmed: 29981800
J R Soc Interface. 2020 Aug;17(169):20200264
pubmed: 32752998
Nat Rev Dis Primers. 2017 Mar 09;3:17009
pubmed: 28276433
Am J Respir Crit Care Med. 1999 Feb;159(2):646-78
pubmed: 9927386
Math Biosci. 2022 Oct;352:108895
pubmed: 36037860
PLoS Comput Biol. 2018 Oct 1;14(10):e1006502
pubmed: 30273354
Polymers (Basel). 2020 Oct 28;12(11):
pubmed: 33126468
Semin Oncol Nurs. 2009 Feb;25(1):3-14
pubmed: 19217502
Front Oncol. 2021 Jan 19;10:621329
pubmed: 33552993
Elife. 2021 Nov 29;10:
pubmed: 34842141
PLoS Comput Biol. 2017 Jun 30;13(6):e1005569
pubmed: 28665934
PLoS One. 2009 Dec 31;4(12):e8515
pubmed: 20046881
Cancer Med. 2019 Nov;8(16):7018-7031
pubmed: 31560828
Phys Rev E Stat Nonlin Soft Matter Phys. 2005 May;71(5 Pt 1):051910
pubmed: 16089574
Cell Prolif. 2001 Aug;34(4):253-66
pubmed: 11529883
Int J Numer Method Biomed Eng. 2018 Mar;34(3):
pubmed: 28898926
Biomech Model Mechanobiol. 2013 Nov;12(6):1089-100
pubmed: 23277411
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Dec;80(6 Pt 1):061903
pubmed: 20365186
PLoS Comput Biol. 2017 Feb 13;13(2):e1005387
pubmed: 28192427
Nat Rev Dis Primers. 2017 Oct 26;3:17077
pubmed: 29072302
Commun Biol. 2022 Jan 24;5(1):91
pubmed: 35075254
J Theor Biol. 2007 Jul 7;247(1):186-204
pubmed: 17416390
Nat Commun. 2015 Jan 22;6:6111
pubmed: 25608921
Biophys J. 2005 Jan;88(1):62-75
pubmed: 15475585
Phys Biol. 2009 Apr 15;6(3):036001
pubmed: 19369704
Sheng Li Xue Bao. 2020 Jun 25;72(3):308-324
pubmed: 32572429
Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Nov;90(5-1):052711
pubmed: 25493820
Pediatr Nephrol. 2015 Jun;30(6):865-72
pubmed: 24633402
PLoS Comput Biol. 2018 Feb 23;14(2):e1005991
pubmed: 29474446
Bull Math Biol. 2020 Oct 6;82(10):132
pubmed: 33025278
J Theor Biol. 2021 Apr 7;514:110535
pubmed: 33259848
Phys Biol. 2012;9(2):026009
pubmed: 22476663
J Theor Biol. 2018 Apr 14;443:66-81
pubmed: 29391171
Elife. 2020 Aug 19;9:
pubmed: 32812871
Cell Prolif. 2009 Oct;42(5):617-36
pubmed: 19622103
Bull Math Biol. 2010 Oct;72(7):1696-731
pubmed: 20082148
Dev Growth Differ. 2015 May;57(4):313-23
pubmed: 25988719
Curr Opin Cell Biol. 2014 Feb;26:87-95
pubmed: 24529250
Proc Natl Acad Sci U S A. 2000 Sep 12;97(19):10448-53
pubmed: 10984537