Reaction kinetics of chitosan nanogels crosslinked by genipin.
Chitosan
Crosslinking
Field-flow fractionation
Genipin
Nanogel
Journal
Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488
Informations de publication
Date de publication:
08 Nov 2023
08 Nov 2023
Historique:
received:
16
07
2023
revised:
16
09
2023
accepted:
29
09
2023
medline:
1
11
2023
pubmed:
10
10
2023
entrez:
9
10
2023
Statut:
ppublish
Résumé
Crosslinking of chitosan chains in dilute solution by natural crosslinker genipin leads to biocompatible nanogels. Here we investigated the reaction kinetics between chitosan and genipin in a 200 mM acetate buffer at 37 °C, and the structural and conformational evolutions of the nanogels during the crosslinking reaction by multi detection asymmetric flow field-flow fractionation (AF4). Upon crosslinking by genipin, the z-average hydrodynamic radius R
Identifiants
pubmed: 37812945
pii: S0021-9673(23)00652-0
doi: 10.1016/j.chroma.2023.464427
pii:
doi:
Substances chimiques
Chitosan
9012-76-4
genipin
A3V2NE52YG
Nanogels
0
Iridoids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
464427Informations de copyright
Copyright © 2023. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.