Reaction kinetics of chitosan nanogels crosslinked by genipin.

Chitosan Crosslinking Field-flow fractionation Genipin Nanogel

Journal

Journal of chromatography. A
ISSN: 1873-3778
Titre abrégé: J Chromatogr A
Pays: Netherlands
ID NLM: 9318488

Informations de publication

Date de publication:
08 Nov 2023
Historique:
received: 16 07 2023
revised: 16 09 2023
accepted: 29 09 2023
medline: 1 11 2023
pubmed: 10 10 2023
entrez: 9 10 2023
Statut: ppublish

Résumé

Crosslinking of chitosan chains in dilute solution by natural crosslinker genipin leads to biocompatible nanogels. Here we investigated the reaction kinetics between chitosan and genipin in a 200 mM acetate buffer at 37 °C, and the structural and conformational evolutions of the nanogels during the crosslinking reaction by multi detection asymmetric flow field-flow fractionation (AF4). Upon crosslinking by genipin, the z-average hydrodynamic radius R

Identifiants

pubmed: 37812945
pii: S0021-9673(23)00652-0
doi: 10.1016/j.chroma.2023.464427
pii:
doi:

Substances chimiques

Chitosan 9012-76-4
genipin A3V2NE52YG
Nanogels 0
Iridoids 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

464427

Informations de copyright

Copyright © 2023. Published by Elsevier B.V.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Xinyue Zhao (X)

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.

Jian Tang (J)

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.

Yanhua Liu (Y)

College of Food science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Bing Hu (B)

College of Food science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Quan Chen (Q)

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China. Electronic address: qchen@ciac.ac.cn.

Yonggang Liu (Y)

State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. Electronic address: yonggang@ciac.ac.cn.

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Classifications MeSH