Human Presenilin-1 delivered by AAV9 rescues impaired γ-secretase activity, memory deficits, and neurodegeneration in
Alzheimer’s disease
gene therapy
gliosis
learning and memory
synaptic plasticity
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
17 10 2023
17 10 2023
Historique:
medline:
2
11
2023
pubmed:
10
10
2023
entrez:
10
10
2023
Statut:
ppublish
Résumé
Mutations in the
Identifiants
pubmed: 37816062
doi: 10.1073/pnas.2306714120
pmc: PMC10589670
doi:
Substances chimiques
Amyloid Precursor Protein Secretases
EC 3.4.-
Presenilin-1
0
Amyloid beta-Protein Precursor
0
Presenilin-2
0
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2306714120Subventions
Organisme : NIA NIH HHS
ID : RF1 AG063520
Pays : United States
Organisme : NINDS NIH HHS
ID : RF1 NS041783
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS041783
Pays : United States
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