Needles in fungal haystacks: Discovery of a putative a-factor pheromone and a unique mating strategy in the Leotiomycetes.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2023
2023
Historique:
received:
04
07
2023
accepted:
25
09
2023
medline:
1
11
2023
pubmed:
12
10
2023
entrez:
12
10
2023
Statut:
epublish
Résumé
The Leotiomycetes is a hugely diverse group of fungi, accommodating a wide variety of important plant and animal pathogens, ericoid mycorrhizal fungi, as well as producers of antibiotics. Despite their importance, the genetics of these fungi remain relatively understudied, particularly as they don't include model taxa. For example, sexual reproduction and the genetic mechanisms that underly this process are poorly understood in the Leotiomycetes. We exploited publicly available genomic and transcriptomic resources to identify genes of the mating-type locus and pheromone response pathway in an effort to characterize the mating strategies and behaviors of 124 Leotiomycete species. Our analyses identified a putative a-factor mating pheromone in these species. This significant finding represents the first identification of this gene in Pezizomycotina species outside of the Sordariomycetes. A unique mating strategy was also discovered in Lachnellula species that appear to have lost the need for the primary MAT1-1-1 protein. Ancestral state reconstruction enabled the identification of numerous transitions between homothallism and heterothallism in the Leotiomycetes and suggests a heterothallic ancestor for this group. This comprehensive catalog of mating-related genes from such a large group of fungi provides a rich resource from which in-depth, functional studies can be conducted in these economically and ecologically important species.
Identifiants
pubmed: 37824487
doi: 10.1371/journal.pone.0292619
pii: PONE-D-23-20830
pmc: PMC10569646
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0292619Informations de copyright
Copyright: © 2023 Wilson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Mol Plant Pathol. 2001 Nov 1;2(6):303-9
pubmed: 20573019
mBio. 2021 Feb 16;12(1):
pubmed: 33593979
Curr Genet. 2000 Jun;37(6):403-11
pubmed: 10905431
Microbiol Mol Biol Rev. 2021 Dec 15;85(4):e0002021
pubmed: 34585983
Methods Mol Biol. 2012;917:3-15
pubmed: 22956079
Brief Bioinform. 2019 Jul 19;20(4):1160-1166
pubmed: 28968734
Curr Biol. 2021 Apr 26;31(8):1653-1665.e5
pubmed: 33607033
Mol Biol Evol. 2011 Jul;28(7):1987-2003
pubmed: 21252281
Fungal Biol. 2016 Sep;120(9):1105-17
pubmed: 27567717
Cell. 1982 Oct;30(3):933-43
pubmed: 6754095
mBio. 2022 Jun 28;13(3):e0110022
pubmed: 35638737
PLoS Genet. 2013;9(7):e1003642
pubmed: 23935511
PLoS One. 2013;8(2):e56895
pubmed: 23457637
Appl Environ Microbiol. 2015 Mar;81(5):1550-8
pubmed: 25527531
PLoS One. 2013 Jun 24;8(6):e66980
pubmed: 23826182
Mol Gen Genet. 1992 May;233(1-2):113-21
pubmed: 1534866
IMA Fungus. 2019 Oct 30;10:19
pubmed: 32647623
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
Plant Dis. 2015 May;99(5):699-708
pubmed: 30699681
Bioessays. 2016 Nov;38(11):1141-1149
pubmed: 27650253
Mol Microbiol. 2003 Aug;49(3):717-30
pubmed: 12864854
Front Endocrinol (Lausanne). 2020 Oct 05;11:554994
pubmed: 33123086
J Biol Chem. 2017 Mar 3;292(9):3591-3602
pubmed: 28100777
Eukaryot Cell. 2010 Jun;9(6):894-905
pubmed: 20435701
IMA Fungus. 2019 Jun 7;10:1
pubmed: 32647610
Curr Biol. 2023 Oct 9;33(19):4098-4110.e3
pubmed: 37699395
Curr Genet. 2020 Oct;66(5):989-1002
pubmed: 32572596
Phytopathology. 2018 Nov;108(11):1315-1325
pubmed: 29767553
Fungal Genet Biol. 2020 Apr;137:103335
pubmed: 31958567
Bioinformatics. 2019 Feb 1;35(3):526-528
pubmed: 30016406
Mol Microbiol. 2002 Aug;45(3):795-804
pubmed: 12139624
Nature. 2015 Nov 26;527(7579):521-4
pubmed: 26503056
Genetics. 2012 Apr;190(4):1389-404
pubmed: 22298702
Fungal Biol. 2017 Dec;121(12):1011-1024
pubmed: 29122173
PLoS Genet. 2016 Jun 21;12(6):e1006110
pubmed: 27327578
Mol Microbiol. 2010 Nov;78(4):964-79
pubmed: 21062371
Fungal Genet Biol. 2018 May;114:24-33
pubmed: 29530630
Mol Biol Evol. 2021 Sep 27;38(10):4647-4654
pubmed: 34320186
Fungal Genet Biol. 2002 Oct;37(1):72-80
pubmed: 12223191
G3 (Bethesda). 2013 Mar;3(3):465-80
pubmed: 23450093
PLoS One. 2014 Mar 20;9(3):e92180
pubmed: 24651494
Bioinformatics. 2015 Oct 1;31(19):3210-2
pubmed: 26059717
Sci Rep. 2016 Jun 03;6:27083
pubmed: 27255676
IMA Fungus. 2015 Jun;6(1):207-14
pubmed: 26203424
Fungal Genet Biol. 2011 Jul;48(7):668-76
pubmed: 21496492
Phytopathology. 2000 Jan;90(1):31-7
pubmed: 18944569
Curr Genet. 2002 Dec;42(3):153-60
pubmed: 12491009
Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1476-81
pubmed: 23307807
Mol Biol Evol. 2012 Oct;29(10):3215-26
pubmed: 22593224
Microbiology (Reading). 2013 Jun;159(Pt 6):1077-1085
pubmed: 23619001
Curr Biol. 2019 Aug 5;29(15):2555-2562.e8
pubmed: 31353182
G3 (Bethesda). 2021 Feb 9;11(2):
pubmed: 33598705
Curr Biol. 2008 Nov 11;18(21):1675-9
pubmed: 18976912
Front Microbiol. 2020 Jun 25;11:1337
pubmed: 32714294
Mycoses. 2014 Dec;57 Suppl 3:18-24
pubmed: 25175551
BMC Bioinformatics. 2006 Feb 09;7:62
pubmed: 16469098
Mycopathologia. 2019 Oct;184(5):637-644
pubmed: 31414314
PLoS Genet. 2011 Aug;7(8):e1002230
pubmed: 21876677
Nat Microbiol. 2019 Sep;4(9):1443-1449
pubmed: 31133754
Mol Biol Evol. 2020 May 1;37(5):1530-1534
pubmed: 32011700
Stud Mycol. 2018 Sep;91:37-59
pubmed: 30425416
Mol Biol Evol. 2018 Feb 1;35(2):518-522
pubmed: 29077904
Mol Biol Evol. 2015 Jan;32(1):268-74
pubmed: 25371430
Exp Mol Med. 2021 Mar;53(3):310-317
pubmed: 33649498
Science. 2006 Feb 17;311(5763):960-1
pubmed: 16484481
G3 (Bethesda). 2021 Sep 6;11(9):
pubmed: 34544120
Bioinformatics. 2009 Aug 1;25(15):1972-3
pubmed: 19505945
Fungal Genet Biol. 1999 Jul-Aug;27(2-3):253-63
pubmed: 10441451
PLoS One. 2014 Oct 20;9(10):e110398
pubmed: 25329823
Fungal Genet Biol. 2004 Nov;41(11):982-97
pubmed: 15465387
Eukaryot Cell. 2008 Jul;7(7):1211-21
pubmed: 18503004
PLoS One. 2014 Feb 28;9(2):e89883
pubmed: 24587098
Genetics. 1998 Mar;148(3):1069-79
pubmed: 9539425
Eukaryot Cell. 2008 Mar;7(3):465-70
pubmed: 18223118
Mycology. 2014 Oct 2;5(4):228-290
pubmed: 25544935
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13909-14
pubmed: 19667182
Nat Methods. 2017 Jun;14(6):587-589
pubmed: 28481363
FEMS Microbiol Lett. 2007 Dec;277(1):1-10
pubmed: 17986079
PLoS One. 2018 Mar 5;13(3):e0192517
pubmed: 29505565
Mycorrhiza. 2018 May;28(4):379-389
pubmed: 29700603
Fungal Biol. 2021 Jun;125(6):427-434
pubmed: 34024590
Mol Cell Biol. 1998 Feb;18(2):953-9
pubmed: 9447992
BMC Bioinformatics. 2018 May 8;19(Suppl 6):153
pubmed: 29745866
Microbiology (Reading). 2003 Sep;149(Pt 9):2301-2303
pubmed: 12949156
Curr Biol. 2022 Aug 22;32(16):3628-3635.e3
pubmed: 35830854
Stud Mycol. 2018 Oct 11;92:195-225
pubmed: 31998413
Syst Biol. 2010 May;59(3):307-21
pubmed: 20525638
Mol Phylogenet Evol. 2022 Jun;171:107456
pubmed: 35358693
J Evol Biol. 2013 Aug;26(8):1716-26
pubmed: 23701131
Eukaryot Cell. 2002 Dec;1(6):987-99
pubmed: 12477799
Fungal Genet Biol. 2015 Jul;80:1-9
pubmed: 25910452