LINC01980 induced by TGF-beta promotes hepatocellular carcinoma metastasis via miR-376b-5p/E2F5 axis.
Humans
Carcinoma, Hepatocellular
/ pathology
Liver Neoplasms
/ pathology
MicroRNAs
/ genetics
RNA, Long Noncoding
/ genetics
Transforming Growth Factor beta
/ metabolism
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Cell Proliferation
/ genetics
Epithelial-Mesenchymal Transition
/ genetics
Cell Movement
/ genetics
E2F5 Transcription Factor
/ genetics
Hepatocellular carcinoma
Long noncoding RNA
Metastasis
TGF-β
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
20
07
2023
revised:
26
09
2023
accepted:
09
10
2023
medline:
3
11
2023
pubmed:
13
10
2023
entrez:
12
10
2023
Statut:
ppublish
Résumé
Hepatocellular carcinoma (HCC) is one of the most aggressive human malignancies worldwide. However, the molecular mechanism of HCC metastasis is largely unknown. Long non-coding RNA (lncRNA) plays a key role in gene regulation, and dysregulation of lncRNA is critical to cancer metastasis. LINC01980 has been reported in ESCC recently, but the mechanism underlying its function in HCC is still unknown. In this study, we found that LINC01980 was upregulated and associated with notably poor overall survival in HCC patients. Functionally, LINC01980 played a carcinogenic role and promoted HCC metastasis. Mechanically, LINC01980 enhanced the E2F5 expression via competitively binding miR-376b-5p, thereby inducing epithelial-mesenchymal transition and promoting HCC cells migration and invasion. In addition, LINC01980-mediated HCC cells metastasis was dependent on E2F5. What's more, TGF-β activated LINC01980 transcription through the canonical TGF-β/SMAD signaling pathway in HCC. In conclusion, LINC01980, activated by the canonical TGF-β/SMAD pathway, promoted HCC metastasis via miR-376b-5p/E2F5 axis. Therefore, LINC01980 might be a potential prognostic biomarker and therapeutic target of HCC.
Identifiants
pubmed: 37827344
pii: S0898-6568(23)00338-8
doi: 10.1016/j.cellsig.2023.110923
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Long Noncoding
0
Transforming Growth Factor beta
0
E2F5 protein, human
0
E2F5 Transcription Factor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110923Informations de copyright
Copyright © 2023 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no competing interests.