An Overview of the Role of Furin in Type 2 Diabetes.
furin
furin variants
mTOR
metabolic disorders
prediabetes
proprotein convertase
therapeutic target
type 2 diabetes
β-cell
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
05 10 2023
05 10 2023
Historique:
received:
27
07
2023
accepted:
27
09
2023
medline:
1
11
2023
pubmed:
13
10
2023
entrez:
13
10
2023
Statut:
epublish
Résumé
Post-translational modifications (PTMs) play important roles in regulating several human diseases, like cancer, neurodegenerative disorders, and metabolic disorders. Investigating PTMs' contribution to protein functions is critical for modern biology and medicine. Proprotein convertases (PCs) are irreversible post-translational modifiers that have been extensively studied and are considered as key targets for novel therapeutics. They cleave proteins at specific sites causing conformational changes affecting their functions. Furin is considered as a PC model in regulating growth factors and is involved in regulating many pro-proteins. The mammalian target of the rapamycin (mTOR) signaling pathway is another key player in regulating cellular processes and its dysregulation is linked to several diseases including type 2 diabetes (T2D). The role of furin in the context of diabetes has been rarely explored and is currently lacking. Moreover, furin variants have altered activity that could have implications on overall health. In this review, we aim to highlight the role of furin in T2D in relation to mTOR signaling. We will also address furin genetic variants and their potential effect on T2D and β-cell functions. Understanding the role of furin in prediabetes and dissecting it from other confounding factors like obesity is crucial for future therapeutic interventions in metabolic disorders.
Identifiants
pubmed: 37830621
pii: cells12192407
doi: 10.3390/cells12192407
pmc: PMC10571965
pii:
doi:
Substances chimiques
Furin
EC 3.4.21.75
Proprotein Convertases
EC 3.4.21.-
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
J Biol Chem. 1990 Dec 25;265(36):22075-8
pubmed: 2266110
Biomed Rep. 2015 Sep;3(5):641-647
pubmed: 26405538
Virus Res. 2015 Apr 16;202:120-34
pubmed: 25445340
Transl Neurodegener. 2022 Aug 23;11(1):39
pubmed: 35996194
Hypertension. 2002 Feb;39(2 Pt 2):399-404
pubmed: 11882580
JCI Insight. 2020 Jul 23;5(14):
pubmed: 32516140
EMBO Mol Med. 2016 Jan 15;8(3):232-46
pubmed: 26772600
Nat Rev Mol Cell Biol. 2009 May;10(5):307-18
pubmed: 19339977
Clin Transl Immunology. 2019 Aug 05;8(8):e1073
pubmed: 31406574
Proc Natl Acad Sci U S A. 1992 Sep 15;89(18):8822-6
pubmed: 1528899
Trends Cell Biol. 1999 Jan;9(1):28-35
pubmed: 10087614
Cold Spring Harb Perspect Biol. 2014 Jan 01;6(1):
pubmed: 24384568
Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6842-6
pubmed: 9192653
Viruses. 2023 Jan 27;15(2):
pubmed: 36851576
Cell. 2006 Oct 6;127(1):125-37
pubmed: 16962653
J Biol Chem. 1993 Nov 15;268(32):24274-7
pubmed: 8226974
Ann N Y Acad Sci. 1999 Oct 20;885:57-74
pubmed: 10816641
Arterioscler Thromb Vasc Biol. 2001 May;21(5):785-90
pubmed: 11348875
Pharmacol Res. 2017 Feb;116:87-92
pubmed: 28025104
Diabetes Obes Metab. 2012 Oct;14 Suppl 3:152-60
pubmed: 22928576
J Intern Med. 2018 Oct;284(4):377-387
pubmed: 29888466
BMJ. 2018 Jul 12;362:k601
pubmed: 30002074
J Cell Biol. 1990 Dec;111(6 Pt 2):2851-9
pubmed: 2269657
Atherosclerosis. 2017 Jul;262:163-170
pubmed: 28400053
Burns. 2011 Feb;37(1):86-93
pubmed: 20594757
Am J Pathol. 2001 Jan;158(1):305-16
pubmed: 11141505
J Neurosci. 1995 Mar;15(3 Pt 1):1778-96
pubmed: 7891135
Nat Med. 2020 Apr;26(4):450-452
pubmed: 32284615
Annu Rev Immunol. 1998;16:137-61
pubmed: 9597127
FEBS Lett. 1996 Feb 5;379(3):247-50
pubmed: 8603699
Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8108-12
pubmed: 9653148
Nat Cell Biol. 2004 Nov;6(11):1122-8
pubmed: 15467718
Mol Biol Cell. 2000 Jul;11(7):2387-401
pubmed: 10888676
Diabetes. 2021 Feb;70(2):492-503
pubmed: 33277337
J Cell Biol. 1999 Jan 11;144(1):139-49
pubmed: 9885250
Nat Rev Drug Discov. 2012 May;11(5):367-83
pubmed: 22679642
Nat Rev Genet. 2003 Jul;4(7):544-58
pubmed: 12838346
Methods Mol Biol. 2011;768:23-57
pubmed: 21805237
Hypertens Res. 2019 Nov;42(11):1808-1815
pubmed: 31253944
Peptides. 2013 Sep;47:99-109
pubmed: 23891651
PLoS Pathog. 2015 Nov 06;11(11):e1005261
pubmed: 26545254
Front Endocrinol (Lausanne). 2022 Mar 25;13:873012
pubmed: 35399937
Biochimie. 1994;76(3-4):197-209
pubmed: 7819324
Cell. 2002 Jul 26;110(2):177-89
pubmed: 12150926
Cell. 2002 Jul 26;110(2):163-75
pubmed: 12150925
Int J Biochem Cell Biol. 1998 Mar;30(3):293-8
pubmed: 9611771
Diabetes. 1997 Aug;46(8):1296-304
pubmed: 9231654
Biochim Biophys Acta. 2003 Jan 31;1645(1):95-104
pubmed: 12535616
Postgrad Med J. 2021 Apr;97(1146):234-238
pubmed: 32114491
DNA Cell Biol. 1991 Dec;10(10):757-69
pubmed: 1741956
Development. 1998 Dec;125(24):4863-76
pubmed: 9811571
EMBO J. 1998 Aug 17;17(16):4735-43
pubmed: 9707432
Mol Cell. 2002 Sep;10(3):457-68
pubmed: 12408816
J Biol Chem. 1994 Oct 14;269(41):25830-7
pubmed: 7929288
FEBS Lett. 2000 Sep 1;480(2-3):169-74
pubmed: 11034322
Am J Physiol. 1999 Jul;277(1):G183-90
pubmed: 10409166
Cell Rep. 2021 Oct 12;37(2):109821
pubmed: 34644569
Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12319-24
pubmed: 18713856
Antiviral Res. 2020 Apr;176:104742
pubmed: 32057769
Heliyon. 2021 Feb;7(2):e06133
pubmed: 33532652
Nature. 2000 Dec 21-28;408(6815):994-7
pubmed: 11140689
Nat Genet. 2010 Jul;42(7):579-89
pubmed: 20581827
Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):47-50
pubmed: 29465367
J Biol Chem. 2000 Jan 28;275(4):2349-58
pubmed: 10644685
Cell. 2007 Jun 29;129(7):1261-74
pubmed: 17604717
Chem Rev. 2011 Oct 12;111(10):6022-63
pubmed: 21696217
Diabetes. 1995 Sep;44(9):1075-80
pubmed: 7657031
Endocrinology. 2005 Feb;146(2):713-27
pubmed: 15528303
Mediators Inflamm. 2017;2017:4803156
pubmed: 28522899
J Med Virol. 2022 Aug;94(8):3589-3595
pubmed: 35355278
Endocrinology. 2004 Apr;145(4):1961-71
pubmed: 14684599
Science. 2005 Feb 18;307(5712):1098-101
pubmed: 15718470
Int J Mol Sci. 2021 May 30;22(11):
pubmed: 34070931
BMC Med Genet. 2010 Aug 13;11:124
pubmed: 20707915
Front Endocrinol (Lausanne). 2022 Jan 03;12:781890
pubmed: 35046896
J Cardiovasc Pharmacol. 1995;26 Suppl 3:S47-50
pubmed: 8587448