Regional transcriptomic profiling reveals immune system enrichment in nonfailing atria and all chambers of the failing human heart.
heart failure
immune system
normal heart
transcriptomics
upstream regulators
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 12 2023
01 12 2023
Historique:
medline:
28
11
2023
pubmed:
13
10
2023
entrez:
13
10
2023
Statut:
ppublish
Résumé
The different chambers of the human heart demonstrate regional physiological traits and may be differentially affected during pathological remodeling, resulting in heart failure. Few previous studies, however, have characterized the different chambers at a transcriptomic level. We, therefore, conducted whole tissue RNA sequencing and gene set enrichment analysis of biopsies collected from the four chambers of adult failing (
Identifiants
pubmed: 37830984
doi: 10.1152/ajpheart.00438.2023
doi:
Substances chimiques
Transforming Growth Factor beta
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
H1430-H1445Subventions
Organisme : The Swedish Society of Medicine
Organisme : The Gothenburg Society of Medicine
Organisme : Hjärt-Lungfonden (Swedish Heart-Lung Foundation)
Organisme : The Emelle Foundation
Organisme : The Foundations of the Sahlgrenska University Hospital
Organisme : The University of Skovde
Organisme : The Swedish Knowledge Foundation
Organisme : The Foundation Research Without Animal Experiments
Organisme : The Swedish Royal Academy
Organisme : ALF research grants from the Sahlgrenska University Hospital