Involvement of Epithelial-Mesenchymal Transition (EMT) in Autoimmune Diseases.
Sjögren’s disease
TGF-β
adaptive immunity
autoimmune disease
chronic inflammation
epithelial to mesenchymal transition
fibrosis
innate immunity
myofibroblast
rheumatic diseases
rheumatoid arthritis
systemic lupus erythematosus
systemic sclerosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Sep 2023
23 Sep 2023
Historique:
received:
01
08
2023
revised:
16
09
2023
accepted:
18
09
2023
medline:
1
11
2023
pubmed:
14
10
2023
entrez:
14
10
2023
Statut:
epublish
Résumé
Epithelial-mesenchymal transition (EMT) is a complex reversible biological process characterized by the loss of epithelial features and the acquisition of mesenchymal features. EMT was initially described in developmental processes and was further associated with pathological conditions including metastatic cascade arising in neoplastic progression and organ fibrosis. Fibrosis is delineated by an excessive number of myofibroblasts, resulting in exuberant production of extracellular matrix (ECM) proteins, thereby compromising organ function and ultimately leading to its failure. It is now well acknowledged that a significant number of myofibroblasts result from the conversion of epithelial cells via EMT. Over the past two decades, evidence has accrued linking fibrosis to many chronic autoimmune and inflammatory diseases, including systemic sclerosis (SSc), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjögren's syndrome (SS), and inflammatory bowel diseases (IBD). In addition, chronic inflammatory states observed in most autoimmune and inflammatory diseases can act as a potent trigger of EMT, leading to the development of a pathological fibrotic state. In the present review, we aim to describe the current state of knowledge regarding the contribution of EMT to the pathophysiological processes of various rheumatic conditions.
Identifiants
pubmed: 37833928
pii: ijms241914481
doi: 10.3390/ijms241914481
pmc: PMC10572663
pii:
doi:
Substances chimiques
Extracellular Matrix Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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