Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism.

exercise exercise performance ketogenic diet ketone bodies ketone supplements metabolism skeletal muscle

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
30 Sep 2023
Historique:
received: 01 09 2023
revised: 23 09 2023
accepted: 25 09 2023
medline: 23 10 2023
pubmed: 14 10 2023
entrez: 14 10 2023
Statut: epublish

Résumé

In recent years, ketogenic diets and ketone supplements have increased in popularity, particularly as a mechanism to improve exercise performance by modifying energetics. Since the skeletal muscle is a major metabolic and locomotory organ, it is important to take it into consideration when considering the effect of a dietary intervention, and the impact of physical activity on the body. The goal of this review is to summarize what is currently known and what still needs to be investigated concerning the relationship between ketone body metabolism and exercise, specifically in the skeletal muscle. Overall, it is clear that increased exposure to ketone bodies in combination with exercise can modify skeletal muscle metabolism, but whether this effect is beneficial or detrimental remains unclear and needs to be further interrogated before ketogenic diets or exogenous ketone supplementation can be recommended.

Identifiants

pubmed: 37836512
pii: nu15194228
doi: 10.3390/nu15194228
pmc: PMC10574738
pii:
doi:

Substances chimiques

Ketones 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : CIHR
ID : 173515
Pays : Canada
Organisme : CIHR
ID : FBD-187636
Pays : Canada

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Auteurs

Hannah Khouri (H)

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Institut du Savoir Montfort, Hôpital Montfort, Ottawa, ON K1K 0T2, Canada.

John R Ussher (JR)

Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2H5, Canada.

Céline Aguer (C)

Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada.
Institut du Savoir Montfort, Hôpital Montfort, Ottawa, ON K1K 0T2, Canada.
Department of Physiology, Faculty of Medicine and Health Sciences, McGill University-Campus Outaouais, Gatineau, QC J8V 3T4, Canada.

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Classifications MeSH