Evaluation of Serum Diamine Oxidase as a Diagnostic Test for Histamine Intolerance.


Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
02 Oct 2023
Historique:
received: 13 09 2023
revised: 27 09 2023
accepted: 28 09 2023
medline: 2 11 2023
pubmed: 14 10 2023
entrez: 14 10 2023
Statut: epublish

Résumé

Histamine intolerance (HIT) is a clinical condition caused by decreased intestinal degradation of ingested histamine, primarily due to reduced enzyme diamine oxidase (DAO) activity, leading to histamine accumulation and causing various clinical manifestations. The measurement of serum DAO is commonly used as the main diagnostic test for HIT, although its diagnostic use is still uncertain. In this retrospective study, we aimed to assess the validity of DAO determination in patients with clinically suspected HIT. We measured DAO levels in 249 patients with suspected HIT and 50 healthy adult controls without HIT-related problems. Based on five clinical criteria, we divided patients into two groups: high (all five inclusion criteria; 41 patients) and low probability of HIT (≤4 inclusion criteria; 208 patients). Patients with a "high probability of HIT" had the lowest DAO (median: 8 U/mL, IQR: 6-10) in comparison to patients with a "low probability of HIT (median: 10 U/mL, IQR: 7-16,

Identifiants

pubmed: 37836530
pii: nu15194246
doi: 10.3390/nu15194246
pmc: PMC10574399
pii:
doi:

Substances chimiques

Histamine 820484N8I3
Amine Oxidase (Copper-Containing) EC 1.4.3.21

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Slovenian Research Agency
ID : P3-0360

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Auteurs

Kristina Arih (K)

Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.

Nina Đorđević (N)

Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.

Mitja Košnik (M)

Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, Slovenia.
Laboratory for Clinical Immunology and Molecular Genetics, University Clinic of Respiratory and Allergic Diseases Golnik, 4204 Golnik, Slovenia.

Matija Rijavec (M)

Laboratory for Clinical Immunology and Molecular Genetics, University Clinic of Respiratory and Allergic Diseases Golnik, 4204 Golnik, Slovenia.
Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.

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Classifications MeSH