The metabolic control theory: Its development and its application to mitochondrial oxidative phosphorylation.
Metabolic control analysis
Metabolic control theory
Mitochondrial diseases
Oxidative phoshorylation
Journal
Bio Systems
ISSN: 1872-8324
Titre abrégé: Biosystems
Pays: Ireland
ID NLM: 0430773
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
12
05
2023
revised:
08
09
2023
accepted:
21
09
2023
medline:
27
11
2023
pubmed:
15
10
2023
entrez:
14
10
2023
Statut:
ppublish
Résumé
Metabolic Control Theory (MCT) and Metabolic Control Analysis (MCA) are the two sides, theoretical and experimental, of the measurement of the sensitivity of metabolic networks in the vicinity of a steady state. We will describe the birth and the development of this theory from the first analyses of linear pathways up to a global mathematical theory applicable to any metabolic network. We will describe how the theory, given the global nature of mitochondrial oxidative phosphorylation, solved the problem of what controls mitochondrial ATP synthesis and then how it led to a better understanding of the differential tissue expression of human mitochondrial pathologies and of the heteroplasmy of mitochondrial DNA, leading to the concept of the threshold effect.
Identifiants
pubmed: 37838015
pii: S0303-2647(23)00213-7
doi: 10.1016/j.biosystems.2023.105038
pii:
doi:
Substances chimiques
DNA, Mitochondrial
0
Adenosine Triphosphate
8L70Q75FXE
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105038Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The author declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.