Antineoplastic effects of pharmacological inhibitors of aurora kinases in CSF3R

Humans Aurora Kinase A / metabolism Quinazolines / pharmacology Organophosphates / pharmacology Antineoplastic Agents / pharmacology Receptors, Colony-Stimulating Factor
Aurora kinase inhibitors Ba/F3 CSF3R(T618I) Cell signaling Myeloproliferative neoplasms

Journal

Blood cells, molecules & diseases
ISSN: 1096-0961
Titre abrégé: Blood Cells Mol Dis
Pays: United States
ID NLM: 9509932

Informations de publication

Date de publication:
Jan 2024
Historique:
received: 16 07 2023
revised: 01 10 2023
accepted: 05 10 2023
medline: 6 12 2023
pubmed: 16 10 2023
entrez: 15 10 2023
Statut: ppublish

Résumé

Myeloproliferative neoplasms (MPN) are consolidated as a relevant group of diseases derived from the malfunction of the hematopoiesis process and have as a particular attribute the increased proliferation of myeloid lineage. Among these, chronic neutrophilic leukemia (CNL) is distinguished, caused by the T618I mutation of the CSF3R gene, a trait that generates ligand-independent receptor activation and downstream JAK2/STAT signaling. Previous studies reported that mutations in BCR::ABL1 and JAK2

Identifiants

DOI: 10.1016/j.bcmd.2023.102799 PMID: 37839173
pubmed: 37839173
pii: S1079-9796(23)00076-1
doi: 10.1016/j.bcmd.2023.102799
pii:
doi:

Substances chimiques

2-((3-((4-((5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate 0
Aurora Kinase A EC 2.7.11.1
Quinazolines 0
Organophosphates 0
Antineoplastic Agents 0
CSF3R protein, human 0
Receptors, Colony-Stimulating Factor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

102799

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no competing interests.

Auteurs

Natália Sudan Parducci (NS)

Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Anali Del Milagro Bernabe Garnique (ADMB)

Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Keli Lima (K)

Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil; Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil.

Jorge Antonio Elias Godoy Carlos (JAEG)

Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Natasha Peixoto Fonseca (NP)

Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.

Lívia Bassani Lins de Miranda (LBL)

Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Bruna Oliveira de Almeida (BO)

Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Eduardo Magalhães Rego (EM)

Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.

Fabiola Traina (F)

Department of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil; Center for Cell Based Therapy, São Paulo Research Foundation, Ribeirão Preto, SP, Brazil.

João Agostinho Machado-Neto (JA)

Laboratory of Medical Investigation in Pathogenesis and Targeted Therapy in Onco-Immuno-Hematology (LIM-31), Department of Internal Medicine, Hematology Division, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil. Electronic address: jamachadoneto@usp.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antineoplastic effects of pharmacological...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Aurora kinases › Aurora kinase A › Antineoplastic effects of pharmacological...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › Antineoplastic effects of pharmacological...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Organophosphates › Antineoplastic effects of pharmacological...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antineoplastic effects of pharmacological...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur facteur croissance › Récepteurs aux facteurs de croissance hématopoïétique › Antineoplastic effects of pharmacological...