Cytokine dysregulation despite immunoglobulin replacement therapy in common variable immunodeficiency (CVID).
CVID
IL-1
IL-10
IL-6
TNF-α
common variable immunodeficiency
lipopolysaccharide
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
12
07
2023
accepted:
07
09
2023
medline:
23
10
2023
pubmed:
16
10
2023
entrez:
16
10
2023
Statut:
epublish
Résumé
Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary immunodeficiency. CVID is a heterogeneous disorder with a presumed multifactorial etiology. Intravenous or subcutaneous immunoglobulin replacement therapy (IgRT) can prevent severe infections but not underlying immune dysregulation. In this study, we evaluated the serum concentrations of proinflammatory (TNF-α, IL-1β, IL-6) and immunoregulatory cytokines (IL-10), as well as lipopolysaccharide (LPS) and soluble CD14 (sCD14) in CVID individuals with infectious only (INF-CVID), and those with additional systemic autoimmune and inflammatory disorders (NIC-CVID), and healthy donors (HD). Our results showed increased serum concentrations of TNF-α, IL-1β, IL-6, and IL-10 in both INF-CVID and NIC-CVID subjects compared to HD. However, elevations of TNF-α, IL-1β, IL-6, and IL-10 were significantly more marked in NIC-CVID than INF-CVID. Additionally, LPS concentrations were increased only in NIC-CVID but not in INF-CVID compared to HD. Circulating levels of sCD14 were significantly increased in NIC-CVID compared to both INF-CVID and HD. These findings indicate persistent cytokine dysregulation despite IgRT in individuals with CVID. Moreover, the circulating cytokine profile reveals the heterogeneity of immune dysregulation in different subgroups of CVID subjects.
Identifiants
pubmed: 37841257
doi: 10.3389/fimmu.2023.1257398
pmc: PMC10568625
doi:
Substances chimiques
Cytokines
0
Interleukin-10
130068-27-8
Interleukin-6
0
Tumor Necrosis Factor-alpha
0
Lipopolysaccharides
0
Lipopolysaccharide Receptors
0
Immunoglobulins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1257398Informations de copyright
Copyright © 2023 Poto, Pecoraro, Ferrara, Punziano, Lagnese, Messuri, Loffredo, Spadaro and Varricchi.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer CP declared a shared affiliation with the authors to the handling editor at the time of review. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
Références
Curr Allergy Asthma Rep. 2016 Mar;16(3):19
pubmed: 26857017
J Allergy Clin Immunol. 2022 Jan;149(1):315-326.e9
pubmed: 34146579
J Endotoxin Res. 2005;11(4):225-9
pubmed: 16176659
Cancer Discov. 2022 Jan;12(1):31-46
pubmed: 35022204
Science. 2018 Sep 28;361(6409):
pubmed: 30262472
Cells. 2021 Jan 12;10(1):
pubmed: 33445787
Front Immunol. 2019 Nov 27;10:2812
pubmed: 31827477
Pharmacol Ther. 2022 Aug;236:108105
pubmed: 34974028
J Allergy Clin Immunol. 2014 Jul;134(1):116-26
pubmed: 24582312
Clin Exp Immunol. 2012 Sep;169(3):263-72
pubmed: 22861366
J Leukoc Biol. 2021 Mar;109(3):621-631
pubmed: 32573828
J Allergy Clin Immunol. 2023 Mar;151(3):767-777
pubmed: 36220400
J Clin Immunol. 2014 Nov;34(8):971-8
pubmed: 25246148
J Allergy Clin Immunol. 2011 Jun;127(6):1329-41.e2; quiz 1342-3
pubmed: 21514636
Clin Exp Immunol. 2009 Jun;156(3):446-54
pubmed: 19438597
Transfusion. 2014 Nov;54(11):2871-9
pubmed: 24826802
PLoS One. 2020 Feb 21;15(2):e0228806
pubmed: 32084157
J Allergy Clin Immunol. 2009 Jun;123(6):1268-76.e15
pubmed: 19443021
J Infect Dis. 2011 Mar 15;203(6):780-90
pubmed: 21252259
Cells. 2022 Nov 07;11(21):
pubmed: 36359917
J Investig Allergol Clin Immunol. 2012;22(6):427-31
pubmed: 23101187
Mucosal Immunol. 2016 Nov;9(6):1455-1465
pubmed: 26982597
Front Immunol. 2014 Nov 26;5:605
pubmed: 25505470
J Bone Oncol. 2022 Aug 04;36:100451
pubmed: 35990515
Int J Mol Sci. 2018 Jun 19;19(6):
pubmed: 29921749
J Clin Invest. 2001 Jan;107(2):225-34
pubmed: 11160139
Best Pract Res Clin Endocrinol Metab. 2020 Jan;34(1):101370
pubmed: 31983543
Blood. 2008 Jul 15;112(2):277-86
pubmed: 18319398
Front Immunol. 2018 Jul 13;9:1595
pubmed: 30057581
Front Immunol. 2018 Nov 05;9:2546
pubmed: 30455695
Biomedicines. 2021 May 04;9(5):
pubmed: 34064389
Cancer Metab. 2021 May 12;9(1):23
pubmed: 33980323
J Allergy Clin Immunol. 2019 Jan;143(1):258-265
pubmed: 29935219
J Immunol. 2007 Mar 15;178(6):3932-43
pubmed: 17339494
Int Rev Immunol. 2016;35(1):7-24
pubmed: 26959802
Clin Immunol. 2011 May;139(2):122-32
pubmed: 21300572
J Clin Immunol. 2007 May;27(3):308-16
pubmed: 17510807
J Allergy Clin Immunol. 2018 Mar;141(3):1028-1035
pubmed: 28606585
Front Immunol. 2018 Jan 09;8:1740
pubmed: 29375540
Clin Exp Med. 2023 Oct;23(6):1981-1998
pubmed: 36737487
J Am Coll Cardiol. 2018 Apr 24;71(16):1765-1767
pubmed: 29567211
Int J Immunopathol Pharmacol. 2016 Jun;29(2):241-51
pubmed: 26684629
Nat Commun. 2015 Apr 20;6:6804
pubmed: 25891430
Clin Exp Immunol. 2012 Nov;170(2):202-11
pubmed: 23039891
Clin Exp Immunol. 2012 Dec;170(3):321-32
pubmed: 23121673
Clin Exp Immunol. 2021 May;204(2):251-257
pubmed: 33497464
J Investig Allergol Clin Immunol. 2008;18(6):449-53
pubmed: 19123436
Nat Immunol. 2010 May;11(5):373-84
pubmed: 20404851
Blood. 2012 Feb 16;119(7):1650-7
pubmed: 22180439
Dig Liver Dis. 2019 Nov;51(11):1599-1603
pubmed: 31155490
Immunol Rev. 2019 Jan;287(1):145-161
pubmed: 30565247
J Allergy Clin Immunol. 2018 Jan;141(1):59-68.e4
pubmed: 28669558
J Allergy Clin Immunol. 2020 Aug;146(2):417-428
pubmed: 32057767
J Leukoc Biol. 2015 Dec;98(6):983-94
pubmed: 26216934
J Clin Immunol. 2021 Feb;41(2):362-373
pubmed: 33190167
Nat Rev Immunol. 2012 Feb 03;12(3):168-79
pubmed: 22301850
Arthritis Res Ther. 2012 Sep 24;14(5):223
pubmed: 23043756
Nat Rev Immunol. 2023 May;23(5):289-303
pubmed: 36380021
Cytokine. 2022 Feb;150:155773
pubmed: 34844039
Semin Cancer Biol. 2022 Feb;79:91-104
pubmed: 34280576
J Leukoc Biol. 2016 Apr;99(4):531-40
pubmed: 26467187
Clin Microbiol Rev. 2013 Jan;26(1):2-18
pubmed: 23297256
Biomedicines. 2022 Feb 12;10(2):
pubmed: 35203640
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81
pubmed: 22826226
Ann Allergy Asthma Immunol. 2021 Jul;127(1):19-27
pubmed: 33716149
Front Immunol. 2020 Feb 07;11:149
pubmed: 32117289
Front Immunol. 2018 Nov 13;9:2601
pubmed: 30483263
Cell Immunol. 2013 Feb;281(2):129-33
pubmed: 23623844
Arthritis Rheumatol. 2014 Jul;66(7):1768-78
pubmed: 24644005
Nat Immunol. 2007 Sep;8(9):931-41
pubmed: 17694059
Trends Immunol. 2017 Mar;38(3):206-216
pubmed: 28017520
Ann Allergy Asthma Immunol. 2019 Nov;123(5):461-467
pubmed: 31382019
Adv Exp Med Biol. 2020;1276:27-35
pubmed: 32705592
Front Cell Infect Microbiol. 2013 Jul 24;3:32
pubmed: 23898465
Immunity. 2006 Dec;25(6):941-52
pubmed: 17137799
Annu Rev Pathol. 2023 Jan 24;18:283-310
pubmed: 36266261
Cytokine. 2022 Jun;154:155890
pubmed: 35462264
Ann Allergy Asthma Immunol. 2017 May;118(5):614-620
pubmed: 28254202
Annu Rev Immunol. 1995;13:437-57
pubmed: 7542010
Front Immunol. 2022 May 26;13:894163
pubmed: 35693823
Clin Immunol. 2009 May;131(2):240-53
pubmed: 19162554
Int J Mol Sci. 2023 Feb 03;24(3):
pubmed: 36769357
Blood. 2002 Mar 1;99(5):1544-51
pubmed: 11861266
Clin Exp Immunol. 2017 Jun;188(3):333-341
pubmed: 28000208
Clin Chim Acta. 1985 Aug 15;150(2):119-27
pubmed: 4042365
J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):38-59
pubmed: 26563668
Clin Exp Immunol. 2013 Aug;173(2):259-67
pubmed: 23607448
Hematology Am Soc Hematol Educ Program. 2012;2012:301-5
pubmed: 23233596
Immunity. 2019 Apr 16;50(4):871-891
pubmed: 30995504
J Exp Med. 2014 Sep 22;211(10):2033-45
pubmed: 25225461
Blood. 2012 Aug 30;120(9):1953-4
pubmed: 22936739
J Biol Chem. 2018 Jun 29;293(26):10186-10201
pubmed: 29760187
Front Immunol. 2021 Aug 02;12:712915
pubmed: 34408753
Sci Rep. 2017 Jun 8;7(1):3053
pubmed: 28596518
J Allergy Clin Immunol. 2022 Jun;149(6):2105-2115.e10
pubmed: 34968528
J Clin Immunol. 2010 Mar;30(2):292-300
pubmed: 19997968
J Allergy Clin Immunol. 2012 May;129(5):1425-1426.e3
pubmed: 22541363