Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen.

Brain / physiology Singlet Oxygen Meninges Nitric Oxide Reactive Oxygen Species

Brain’s waste disposal system Meningeal lymphatics Photostimulation Singlet oxygen

Journal

Advances in experimental medicine and biology

ISSN: 0065-2598

Titre abrégé: Adv Exp Med Biol

Pays: United States

ID NLM: 0121103

Informations de publication

Date de publication:
2023

Historique:

medline: 23 10 2023

pubmed: 17 10 2023

entrez: 16 10 2023

Statut: ppublish

Résumé

There is strong evidence that augmentation of the brain's waste disposal system via stimulation of the meningeal lymphatics might be a promising therapeutic target for preventing neurological diseases. In our previous studies, we demonstrated activation of the brain's waste disposal system using transcranial photostimulation (PS) with a laser 1267 nm, which stimulates the direct generation of singlet oxygen in the brain tissues. Here we investigate the mechanisms underlying this phenomenon. Our results clearly demonstrate that PS-mediated stimulation of the brain's waste disposal system is accompanied by activation of lymphatic contractility associated with subsequent intracellular production of the reactive oxygen species and the nitric oxide underlying lymphatic relaxation. Thus, PS stimulates the brain's waste disposal system by influencing the mechanisms of regulation of lymphatic pumping.

Identifiants

DOI: 10.1007/978-3-031-42003-0_8 PMID: 37845438

pubmed: 37845438

doi: 10.1007/978-3-031-42003-0_8

doi:

Substances chimiques

Singlet Oxygen 17778-80-2

Nitric Oxide 31C4KY9ESH

Reactive Oxygen Species 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

45-50

Informations de copyright

Références

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