Analytical description of adolescent binge drinking patients.
Alcoholism
Binge drinkers
Forensic science
Youth
Journal
BMC pediatrics
ISSN: 1471-2431
Titre abrégé: BMC Pediatr
Pays: England
ID NLM: 100967804
Informations de publication
Date de publication:
16 10 2023
16 10 2023
Historique:
received:
05
04
2023
accepted:
23
09
2023
medline:
23
10
2023
pubmed:
17
10
2023
entrez:
16
10
2023
Statut:
epublish
Résumé
Binge drinking is a widespread health compromising behavior among adolescents and young adults, leading to significant health problems, injuries and mortality. However, data on alcohol consumption is often unreliable, as it is mainly based on self-reporting surveys. In this five-year study (2014-2019) at the University Children's Hospital Zurich, we analyzed blood samples from adolescent binge drinking patients to investigate blood alcohol concentrations (BACs), co-ingestion of drugs, assess compliance between self-reported and measured substance use, and test for genetic components of innate alcohol tolerance. Furthermore, hair analysis was performed to retrospectively access drug exposure and to evaluate the potential of hair analysis to assess binge drinking. In a prospective, single-center study, patients with alcohol intoxications aged 16 years and younger were included. Blood and hair samples were analyzed by sensitive liquid chromatography - tandem mass spectrometry drug analysis. HTTLPR genotyping was performed with PCR and fragment analysis. Among 72 cases, 72 blood and 13 hair samples were analyzed. BACs ranged from 0.08-3.20‰ (mean 1.63‰, median 1.60‰), while a mean concentration of 3.64 pg/mg hair (median 3.0 pg/mg) of the alcohol marker ethyl glucuronide (EtG) was detected in eleven hair samples, providing no evidence of chronic excessive drinking. In 47% of the cases, co-ingested drugs were qualitatively detected next to ethanol, but only 9% of the detected drugs had blood concentrations classified as pharmacologically active. Cannabis consumption (22%) and stimulant intake (16%) were the most frequently observed drugs. Compliance between patients' statements and measured substances matched well. Although we investigated the genetic contribution to innate alcohol tolerance via the 5-HTTLPR polymorphism, the diverse genetic background of the cohort and small sample size did not allow any conclusions to be drawn. Almost half of our binge drinking patients tested positive for other substances, primarily cannabis. We anticipate that our study enhances understanding of consumption behavior of young people and encourage continued efforts to address the harmful effects of binge drinking and co-occurring substance use.
Sections du résumé
BACKGROUND
Binge drinking is a widespread health compromising behavior among adolescents and young adults, leading to significant health problems, injuries and mortality. However, data on alcohol consumption is often unreliable, as it is mainly based on self-reporting surveys. In this five-year study (2014-2019) at the University Children's Hospital Zurich, we analyzed blood samples from adolescent binge drinking patients to investigate blood alcohol concentrations (BACs), co-ingestion of drugs, assess compliance between self-reported and measured substance use, and test for genetic components of innate alcohol tolerance. Furthermore, hair analysis was performed to retrospectively access drug exposure and to evaluate the potential of hair analysis to assess binge drinking.
METHODS
In a prospective, single-center study, patients with alcohol intoxications aged 16 years and younger were included. Blood and hair samples were analyzed by sensitive liquid chromatography - tandem mass spectrometry drug analysis. HTTLPR genotyping was performed with PCR and fragment analysis.
RESULTS
Among 72 cases, 72 blood and 13 hair samples were analyzed. BACs ranged from 0.08-3.20‰ (mean 1.63‰, median 1.60‰), while a mean concentration of 3.64 pg/mg hair (median 3.0 pg/mg) of the alcohol marker ethyl glucuronide (EtG) was detected in eleven hair samples, providing no evidence of chronic excessive drinking. In 47% of the cases, co-ingested drugs were qualitatively detected next to ethanol, but only 9% of the detected drugs had blood concentrations classified as pharmacologically active. Cannabis consumption (22%) and stimulant intake (16%) were the most frequently observed drugs. Compliance between patients' statements and measured substances matched well. Although we investigated the genetic contribution to innate alcohol tolerance via the 5-HTTLPR polymorphism, the diverse genetic background of the cohort and small sample size did not allow any conclusions to be drawn.
CONCLUSION
Almost half of our binge drinking patients tested positive for other substances, primarily cannabis. We anticipate that our study enhances understanding of consumption behavior of young people and encourage continued efforts to address the harmful effects of binge drinking and co-occurring substance use.
Identifiants
pubmed: 37845619
doi: 10.1186/s12887-023-04325-2
pii: 10.1186/s12887-023-04325-2
pmc: PMC10577939
doi:
Substances chimiques
Ethanol
3K9958V90M
Blood Alcohol Content
0
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
512Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
Références
Forensic Sci Int. 2014 Nov;244:20-4
pubmed: 25151107
Science. 1996 Nov 29;274(5292):1527-31
pubmed: 8929413
Ther Drug Monit. 2004 Apr;26(2):200-5
pubmed: 15228165
J Neural Transm (Vienna). 1997;104(10):1005-14
pubmed: 9503253
Alcohol Alcohol. 2020 Aug 14;55(5):468-479
pubmed: 32556202
Am J Prev Med. 2021 Feb;60(2):169-178
pubmed: 33482979
Clin Chim Acta. 2006 Aug;370(1-2):17-49
pubmed: 16624267
Forensic Sci Int. 1997 Jan 17;84(1-3):7-16
pubmed: 9042705
Alcohol Alcohol. 2011 Nov-Dec;46(6):709-13
pubmed: 21949190
J Psychiatr Res. 2005 Jul;39(4):371-6
pubmed: 15804387
Anal Chim Acta. 2015 Apr 22;870:29-44
pubmed: 25819785
Epilepsia. 2006 Aug;47(8):1253-84
pubmed: 16922870
Mol Neurobiol. 2016 Oct;53(8):5510-26
pubmed: 26464328
Alcohol Res. 2022 Apr 07;42(1):07
pubmed: 35465194
Anal Chim Acta. 2015 Apr 22;870:8-28
pubmed: 25819784
Dev Psychopathol. 2022 Dec 12;:1-17
pubmed: 36503558
Alcohol Clin Exp Res. 2005 Jan;29(1):8-16
pubmed: 15654286
Brain Behav. 2022 Jan;12(1):e2427
pubmed: 34808037
Forensic Sci Int. 2007 Jan 17;165(2-3):216-24
pubmed: 16781833
Neuropsychopharmacology. 2013 Aug;38(9):1737-47
pubmed: 23518607
Alcohol Alcohol. 2016 Mar;51(2):164-71
pubmed: 26311211
Alcohol Clin Exp Res. 2009 Feb;33(2):332-9
pubmed: 19032574
Neurosci Lett. 1998 Jun 5;248(3):147-50
pubmed: 9654330
Lancet. 1974 Jul 13;2(7872):81-4
pubmed: 4136544
Biol Psychiatry. 1999 Mar 1;45(5):647-51
pubmed: 10088053
Alcohol. 2017 Mar;59:7-16
pubmed: 28262188
Pharmacol Biochem Behav. 2014 Aug;123:17-24
pubmed: 24220019
Alcohol Clin Exp Res. 2004 Oct;28(10):1449-58
pubmed: 15597076
Biol Psychiatry. 2006 Aug 1;60(3):282-7
pubmed: 16497275
Drug Alcohol Depend. 2022 Dec 1;241:109650
pubmed: 36252507
Eur J Clin Nutr. 2004 Jan;58(1):60-3
pubmed: 14679368
Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20368-73
pubmed: 19064933
Leg Med (Tokyo). 2009 Apr;11 Suppl 1:S210-2
pubmed: 19261524
Alcohol Clin Exp Res. 2004 Dec;28(12):1881-9
pubmed: 15608605
J Anal Toxicol. 2021 Aug 14;45(7):701-712
pubmed: 32986078
Forensic Sci Int. 2016 Oct;267:52-59
pubmed: 27552702
Alcohol Alcohol. 2013 Jul-Aug;48(4):386-9
pubmed: 23690233
Alcohol Clin Exp Res. 2006 Jul;30(7):1101-10
pubmed: 16792556