developmental biology
fertility
genetics
genomics
gonads
rabbit
sex determination
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
17 10 2023
17 10 2023
Historique:
medline:
23
10
2023
pubmed:
17
10
2023
entrez:
17
10
2023
Statut:
epublish
Résumé
DMRT1 is the testis-determining factor in several species of vertebrates, but its involvement in mammalian testes differentiation, where Animals that reproduce sexually have organs called gonads, the ovaries and testes, which produce eggs and sperm. These organs, which are different in males and females, originate from the same cells during the development of the embryo. As a general rule, the chromosomal sex of an embryo, which gets determined at fertilization, leads to the activation and repression of specific genes. This in turn, controls whether the cells that will form the gonads will differentiate to develop testes or ovaries. Disruption of the key genes involved in the differentiation of the gonads can lead to fertility problems, and in some cases, it can cause the gonads to develop in the ‘opposite’ direction, resulting in a sex reversal. Identifying these genes is therefore essential to know how to maintain or restore fertility.
Autres résumés
Type: plain-language-summary
(eng)
Animals that reproduce sexually have organs called gonads, the ovaries and testes, which produce eggs and sperm. These organs, which are different in males and females, originate from the same cells during the development of the embryo. As a general rule, the chromosomal sex of an embryo, which gets determined at fertilization, leads to the activation and repression of specific genes. This in turn, controls whether the cells that will form the gonads will differentiate to develop testes or ovaries. Disruption of the key genes involved in the differentiation of the gonads can lead to fertility problems, and in some cases, it can cause the gonads to develop in the ‘opposite’ direction, resulting in a sex reversal. Identifying these genes is therefore essential to know how to maintain or restore fertility.
Identifiants
pubmed: 37847154
doi: 10.7554/eLife.89284
pii: 89284
pmc: PMC10581690
doi:
pii:
Substances chimiques
SOX9 Transcription Factor
0
Banques de données
SRA
['PRJNA899447']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023, Dujardin et al.
Déclaration de conflit d'intérêts
ED, AM, AD, BM, FP, AF, DT, LJ, GJ, EP, MP No competing interests declared
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