Arterial spin labeling MRI using spiral acquisitions and concurrent field monitoring.

Perfusion MRI based on arterial spin labeling (ASL) has intrinsically very low signal-to-noise ratio (SNR). Signal acquisition at shorter echo times (TE) is necessary to boost the SNR of the ASL images. Spiral trajectories provide substantially shorter TE yielding increased SNR and are among the fastest k-space sampling schemes to encode a given field of view and resolution. Moreover, they provide approximately isotropic point-spread functions and inherent refocusing of motion- and flow-induced phase errors. However, the efficiency of the spiral acquisitions in ASL-MRI has been limited because these advantages are counterbalanced by practical technical challenges. This is because spiral acquisitions are highly sensitive to encoding deficiencies such as static off-resonance in the main magnetic field manifested as blurring artifacts in the image. Moreover, deviation of the gradient fields from the nominal waveforms due to the imperfection of the employed hardware critically limits the practical utilization of spiral trajectories. In this work, I provide single- and multiple-shot spiral ASL images that are robust against typical spiral encoding drawbacks enabled by deploying a comprehensive signal model involving static off-resonance and coil sensitivity maps and actual B

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.