The TRH test provides valuable information in the diagnosis of central hypothyroidism in patients with known pituitary disease and low T4 levels.
TRH test
central hypothyroidism
hypopituitarism
pituitary disease
thyrotropin-releasing hormone (TRH)
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2023
2023
Historique:
received:
22
05
2023
accepted:
18
09
2023
medline:
23
10
2023
pubmed:
18
10
2023
entrez:
18
10
2023
Statut:
epublish
Résumé
To evaluate the value of the thyrotropin-releasing hormone (TRH) test in the diagnosis of central hypothyroidism (CH) in patients with pituitary disease. Systematic evaluation of 359 TRH tests in patients with pituitary disease including measurements of thyroxine (T4), TBG-corrected T4 (T4 Patients diagnosed with CH (n=39) show comparable TSH The TRH test could be reserved to patients with pituitary disease, low T4 levels without convincing signs of CH. Approximately 50% of patients with a slightly decreased T4 were considered to have normal pituitary thyroid function based on the TRH test results.
Identifiants
pubmed: 37850100
doi: 10.3389/fendo.2023.1226887
pmc: PMC10577283
doi:
Substances chimiques
Thyrotropin
9002-71-5
Thyrotropin-Releasing Hormone
5Y5F15120W
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1226887Informations de copyright
Copyright © 2023 Christensen, Smith, Rosendal, Gulisano, Ettrup, Vestergaard, Nielsen, Karmisholt and Dal.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
BMC Endocr Disord. 2007 Aug 02;7:5
pubmed: 17678551
J Clin Endocrinol Metab. 1959 Jan;19(1):84-91
pubmed: 13620734
Pituitary. 2015 Feb;18(1):169-75
pubmed: 24554165
Ann Intern Med. 1974 Dec;81(6):751-7
pubmed: 4372919
Horm Res. 2004;61(2):53-7
pubmed: 14646390
J Clin Endocrinol Metab. 1979 Jun;48(6):989-98
pubmed: 109460
Indian J Endocrinol Metab. 2011 Jul;15(Suppl 2):S99-S106
pubmed: 21966662
Front Neuroendocrinol. 2019 Jan;52:29-43
pubmed: 29935915
J Natl Med Assoc. 1987 Nov;79(11):1185-97
pubmed: 3121862
J Clin Endocrinol Metab. 2016 Nov;101(11):3888-3921
pubmed: 27736313
Aust N Z J Med. 1976 Feb;6(1):30-6
pubmed: 820324
Clin Endocrinol (Oxf). 1992 Feb;36(2):135-9
pubmed: 1568346
Lancet. 2017 Sep 23;390(10101):1550-1562
pubmed: 28336049
Age Ageing. 1989 Nov;18(6):398-402
pubmed: 2629488
Endocrinol Metab (Seoul). 2015 Dec;30(4):443-55
pubmed: 26790380
Thyroid. 1998 Oct;8(10):903-8
pubmed: 9827657
Eur J Endocrinol. 2004 Jan;150(1):1-8
pubmed: 14713273