[Magnetic resonance imaging of the lung : State of the art].

Magnetresonanztomographie der Lunge : Stand der Dinge.

Journal

Radiologie (Heidelberg, Germany)
ISSN: 2731-7056
Titre abrégé: Radiologie (Heidelb)
Pays: Germany
ID NLM: 9918384887306676

Informations de publication

Date de publication:
Nov 2023
Historique:
accepted: 04 10 2023
medline: 26 10 2023
pubmed: 18 10 2023
entrez: 18 10 2023
Statut: ppublish

Résumé

Due to the low proton density of the lung parenchyma and the rapid signal decay at the air-tissue interfaces, for a long time the lungs were difficult to access using magnetic resonance imaging (MRI); however, technical advances could address most of these obstacles. Pulmonary alterations associated with tissue proliferation ("plus pathologies"), can now be detected with high diagnostic accuracy because of the locally increased proton density. Compared to computed tomography (CT), MRI provides a comprehensive range of functional imaging procedures (respiratory mechanics, perfusion and ventilation). In addition, as a radiation-free noninvasive examination modality, it enables repeated examinations for assessment of the course or monitoring of the effects of treatment, even in children. This article discusses the technical aspects, gives suggestions for protocols and explains the role of MRI of the lungs in the routine assessment of various diseases. Die Lunge war lange Zeit aufgrund der geringen Protonendichte des Parenchyms sowie des schnellen Signalzerfalls an den Luft-Gewebe-Grenzen der Magnetresonanztomographie (MRT) schwer zugänglich. Technische Neuerungen haben diese Anforderungen größtenteils adressiert. Pulmonale Veränderungen, welche mit Gewebevermehrung einhergehen („Plus-Pathologien“), lassen sich nun aufgrund der lokal vermehrten Protonendichte mit einer hohen diagnostischen Genauigkeit darstellen. Die MRT bietet im Vergleich zur Computertomographie (CT) ein umfassendes Spektrum funktioneller Bildgebungsverfahren (Atemmechanik, Perfusion, Ventilation) sowie – als strahlungsfreie, nicht-invasive Untersuchungsmodalität – die Möglichkeit wiederholter Untersuchungen für Verlaufsbeurteilungen oder die Überwachung von Therapieeffekten, auch bei Kindern. In diesem Artikel besprechen wir technische Aspekte, geben Protokollvorschläge und erörtern die Rolle der Lungen-MRT in der routinemäßigen Beurteilung verschiedener Erkrankungen.

Autres résumés

Type: Publisher (ger)
Die Lunge war lange Zeit aufgrund der geringen Protonendichte des Parenchyms sowie des schnellen Signalzerfalls an den Luft-Gewebe-Grenzen der Magnetresonanztomographie (MRT) schwer zugänglich. Technische Neuerungen haben diese Anforderungen größtenteils adressiert. Pulmonale Veränderungen, welche mit Gewebevermehrung einhergehen („Plus-Pathologien“), lassen sich nun aufgrund der lokal vermehrten Protonendichte mit einer hohen diagnostischen Genauigkeit darstellen. Die MRT bietet im Vergleich zur Computertomographie (CT) ein umfassendes Spektrum funktioneller Bildgebungsverfahren (Atemmechanik, Perfusion, Ventilation) sowie – als strahlungsfreie, nicht-invasive Untersuchungsmodalität – die Möglichkeit wiederholter Untersuchungen für Verlaufsbeurteilungen oder die Überwachung von Therapieeffekten, auch bei Kindern. In diesem Artikel besprechen wir technische Aspekte, geben Protokollvorschläge und erörtern die Rolle der Lungen-MRT in der routinemäßigen Beurteilung verschiedener Erkrankungen.

Identifiants

pubmed: 37851088
doi: 10.1007/s00117-023-01229-1
pii: 10.1007/s00117-023-01229-1
doi:

Substances chimiques

Protons 0

Types de publication

English Abstract Journal Article

Langues

ger

Sous-ensembles de citation

IM

Pagination

849-862

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

Références

Wielpütz M, Kauczor HU (2012) MRI of the lung: state of the art. Diagn Interv Radiol 18:344–353
pubmed: 22434450
Wielpütz MO, Triphan SMF, Ohno Y, Jobst BJ, Kauczor HU (2019) Outracing lung signal decay—potential of Ultrashort echo time MRI. Rofo 191:415–423
pubmed: 30257269
Biederer J, Hintze C, Fabel M (2008) MRI of pulmonary nodules: technique and diagnostic value. Cancer Imaging 8:125–130
pubmed: 18519226 pmcid: 2413430
Ley-Zaporozhan J, Puderbach M, Kauczor HU (2008) MR for the evaluation of obstructive pulmonary disease. Magn Reson Imaging Clin N Am 16:291–308
pubmed: 18474333
Iwasawa T, Takahashi H, Ogura T et al (2007) Correlation of lung parenchymal MR signal intensity with pulmonary function tests and quantitative computed tomography (CT) evaluation: a pilot study. J Magn Reson Imaging 26:1530–1536
pubmed: 17968893
Biederer J, Beer M, Hirsch W et al (2012) MRI of the lung (2/3). Why ... when ... how? Insights Imaging 3:355–371
pubmed: 22695944 pmcid: 3481084
Fink C, Puderbach M, Biederer J et al (2007) Lung MRI at 1.5 and 3 Tesla: observer preference study and lesion contrast using five different pulse sequences. Invest Radiol 42:377–383
pubmed: 17507808
Puderbach M, Hintze C, Ley S, Eichinger M, Kauczor HU, Biederer J (2007) MR imaging of the chest: a practical approach at 1.5T. Eur J Radiol 64:345–355
pubmed: 17900843
Kluge A, Luboldt W, Bachmann G (2006) Acute pulmonary embolism to the subsegmental level: diagnostic accuracy of three MRI techniques compared with 16-MDCT. AJR Am J Roentgenol 187:W7–14
pubmed: 16794142
Johnson KM, Fain SB, Schiebler ML, Nagle S (2013) Optimized 3D ultrashort echo time pulmonary MRI. Magn Reson Med 70:1241–1250
pubmed: 23213020
Longuefosse A, Raoult J, Benlala I et al (2023) Generating high-resolution synthetic CT from lung MRI with ultrashort echo times: initial evaluation in cystic fibrosis. Radiology 308:e230052
pubmed: 37404152
Plathow C, Fink C, Ley S et al (2004) Measurement of diaphragmatic length during the breathing cycle by dynamic MRI: comparison between healthy adults and patients with an intrathoracic tumor. Eur Radiol 14:1392–1399
pubmed: 15127220
Fink C, Puderbach M, Bock M et al (2004) Regional lung perfusion: assessment with partially parallel three-dimensional MR imaging. Radiology 231:175–184
pubmed: 15068947
Wielpütz MO, Puderbach M, Kopp-Schneider A et al (2014) Magnetic resonance imaging detects changes in structure and perfusion, and response to therapy in early cystic fibrosis lung disease. Am J Respir Crit Care Med 189:956–965
pubmed: 24564281
Eichinger M, Puderbach M, Fink C et al (2006) Contrast-enhanced 3D MRI of lung perfusion in children with cystic fibrosis—initial results. Eur Radiol 16:2147–2152
pubmed: 16673092
Triphan SMF, Stahl M, Jobst BJ et al (2020) Echo time-dependence of observed lung T1 in patients with cystic fibrosis and correlation with clinical metrics. J Magn Reson Imaging 52:1645–1654
pubmed: 32613717
Voskrebenzev A, Gutberlet M, Klimes F et al (2018) Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients. Magn Reson Med 79:2306–2314
pubmed: 28856715
Jobst BJ, Triphan SM, Sedlaczek O et al (2015) Functional lung MRI in chronic obstructive pulmonary disease: comparison of T1 mapping, oxygen-enhanced T1 mapping and dynamic contrast enhanced perfusion. PLoS ONE 10:e121520
pubmed: 25822195 pmcid: 4379151
Ley S, Puderbach M, Risse F et al (2007) Impact of oxygen inhalation on the pulmonary circulation: assessment by magnetic resonance (MR)-perfusion and MR-flow measurements. Invest Radiol 42:283–290
pubmed: 17414523
van Beek EJ, Wild JM, Kauczor HU, Schreiber W, Mugler JP 3rd, de Lange EE (2004) Functional MRI of the lung using hyperpolarized 3‑helium gas. J Magn Reson Imaging 20:540–554
pubmed: 15390146
Mannino DM, Doherty DE, Buist SA (2006) Global Initiative on Obstructive Lung Disease (GOLD) classification of lung disease and mortality: findings from the Atherosclerosis Risk in Communities (ARIC) study. Respir Med 100:115–122
pubmed: 15893923
Suga K, Tsukuda T, Awaya H et al (1999) Impaired respiratory mechanics in pulmonary emphysema: evaluation with dynamic breathing MRI. J Magn Reson Imaging 10:510–520
pubmed: 10508317
Iwasawa T, Yoshiike Y, Saito K, Kagei S, Gotoh T, Matsubara S (2000) Paradoxical motion of the hemidiaphragm in patients with emphysema. J Thorac Imaging 15:191–195
pubmed: 10928612
Heussel CP, Ley S, Biedermann A et al (2004) Respiratory lumenal change of the pharynx and trachea in normal subjects and COPD patients: assessment by cine-MRI. Eur Radiol 14:2188–2197
pubmed: 15517280
Theissen IL, Meissner A (1996) Hypoxic pulmonary vasoconstriction. Anaesthesist 45:643–652
pubmed: 8765866
Molinari F, Fink C, Risse F, Tuengerthal S, Bonomo L, Kauczor HU (2006) Assessment of differential pulmonary blood flow using perfusion magnetic resonance imaging: comparison with radionuclide perfusion scintigraphy. Invest Radiol 41:624–630
pubmed: 16829745
Ohno Y, Hatabu H, Murase K et al (2004) Quantitative assessment of regional pulmonary perfusion in the entire lung using three-dimensional ultrafast dynamic contrast-enhanced magnetic resonance imaging: Preliminary experience in 40 subjects. J Magn Reson Imaging 20:353–365
pubmed: 15332240
Schiwek M, Triphan SMF, Biederer J et al (2022) Quantification of pulmonary perfusion abnormalities using DCE-MRI in COPD: comparison with quantitative CT and pulmonary function. Eur Radiol 32:1879–1890
pubmed: 34553255
Ohno Y, Sugimura K, Hatabu H (2003) Clinical oxygen-enhanced magnetic resonance imaging of the lung. Top Magn Reson Imaging 14:237–243
pubmed: 12973131
Marshall H, Deppe MH, Parra-Robles J et al (2012) Direct visualisation of collateral ventilation in COPD with hyperpolarised gas MRI. Thorax 67:613–617
pubmed: 22286930
Ley-Zaporozhan J, Ley S, Kauczor HU (2008) Morphological and functional imaging in COPD with CT and MRI: present and future. Eur Radiol 18:510–521
pubmed: 17899100
Biederer J, Mirsadraee S, Beer M et al (2012) MRI of the lung (3/3)-current applications and future perspectives. Insights Imaging 3:373–386
pubmed: 22695943 pmcid: 3481076
Eichinger M, Heussel CP, Kauczor HU, Tiddens H, Puderbach M (2010) Computed tomography and magnetic resonance imaging in cystic fibrosis lung disease. J Magn Reson Imaging 32:1370–1378
pubmed: 21105141
Wielpütz MO, Eichinger M, Biederer J et al (2016) Imaging of cystic fibrosis lung disease and clinical interpretation. Rofo 188:834–845
pubmed: 27074425
Graeber SY, Zhou-Suckow Z, Schatterny J, Hirtz S, Boucher RC, Mall MA (2013) Hypertonic saline is effective in the prevention and treatment of mucus obstruction, but not airway inflammation, in mice with chronic obstructive lung disease. Am J Respir Cell Mol Biol 49:410–417
pubmed: 23590312 pmcid: 3824058
Biederer J, Both M, Graessner J et al (2003) Lung morphology: fast MR imaging assessment with a volumetric interpolated breath-hold technique: initial experience with patients. Radiology 226:242–249
pubmed: 12511697
Puderbach M, Eichinger M, Gahr J et al (2007) Proton MRI appearance of cystic fibrosis: comparison to CT. Eur Radiol 17:716–724
pubmed: 16941092
Rosenfeld M, Ratjen F, Brumback L et al (2012) Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial. JAMA 307:2269–2277
pubmed: 22610452 pmcid: 3586815
Mentore K, Froh DK, de Lange EE, Brookeman JR, Paget-Brown AO, Altes TA (2005) Hyperpolarized HHe 3 MRI of the lung in cystic fibrosis: assessment at baseline and after bronchodilator and airway clearance treatment. Acad Radiol 12:1423–1429
pubmed: 16253854
Altes TA, Johnson M, Fidler M et al (2017) Use of hyperpolarized helium‑3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis. J Cyst Fibros 16:267–274
pubmed: 28132845
Wucherpfennig L, Triphan SMF, Wege S et al (2022) Magnetic resonance imaging detects improvements of pulmonary and paranasal sinus abnormalities in response to elexacaftor/tezacaftor/ivacaftor therapy in adults with cystic fibrosis. J Cyst Fibros. https://doi.org/10.1016/j.jcf.2022.03.011
doi: 10.1016/j.jcf.2022.03.011 pubmed: 35400600
Eichinger M, Optazaite DE, Kopp-Schneider A et al (2012) Morphologic and functional scoring of cystic fibrosis lung disease using MRI. Eur J Radiol 81:1321–1329
pubmed: 21429685
Stahl M, Steinke E, Graeber SY et al (2021) Magnetic resonance imaging detects progression of lung disease and impact of newborn screening in preschool children with cystic fibrosis. Am J Respir Crit Care Med. https://doi.org/10.1164/rccm.202102-0278OC
doi: 10.1164/rccm.202102-0278OC pubmed: 34283704 pmcid: 8865593
Graeber SY, Renz DM, Stahl M et al (2022) Effects of Elexacaftor/Tezacaftor/Ivacaftor therapy on lung clearance index and magnetic resonance imaging in patients with cystic fibrosis and one or two F508del alleles. Am J Respir Crit Care Med 206:311–320
pubmed: 35536314
Leutz-Schmidt P, Optazaite DE, Sommerburg O et al (2023) Magnetic resonance imaging detects onset and association with lung disease severity of bronchial artery dilatation in cystic fibrosis. ERJ Open Res 9:
Lederlin M, Bauman G, Eichinger M et al (2013) Functional MRI using fourier decomposition of lung signal: reproducibility of ventilation- and perfusion-weighted imaging in healthy volunteers. Eur J Radiol 82:1015–1022
pubmed: 23295084
Bauman G, Puderbach M, Heimann T et al (2013) Validation of fourier decomposition MRI with dynamic contrast-enhanced MRI using visual and automated scoring of pulmonary perfusion in young cystic fibrosis patients. Eur J Radiol 82:2371–2377
pubmed: 24016829
Thomen RP, Walkup LL, Roach DJ, Cleveland ZI, Clancy JP, Woods JC (2017) Hyperpolarized (129)Xe for investigation of mild cystic fibrosis lung disease in pediatric patients. J Cyst Fibros 16:275–282
pubmed: 27477942
Höffken G, Lorenz J, Kern W et al (2009) Epidemiology, diagnosis, antimicrobial therapy and management of community-acquired pneumonia and lower respiratory tract infections in adults. Guidelines of the Paul-Ehrlich-Society for Chemotherapy, the German Respiratory Society, the German Society for Infectiology and the Competence Network CAPNETZ Germany. Pneumologie 63:e1–68
pubmed: 19821215
Dalhoff K, Abele-Horn M, Andreas S et al (2012) Epidemiology, diagnosis and treatment of adult patients with nosocomial pneumonia. S‑3 Guideline of the German Society for Anaesthesiology and Intensive Care Medicine, the German Society for Infectious Diseases, the German Society for Hygiene and Microbiology, the German Respiratory Society and the Paul-Ehrlich-Society for Chemotherapy. Pneumologie 66:707–765
pubmed: 23225407
Self WH, Courtney DM, McNaughton CD, Wunderink RG, Kline JA (2013) High discordance of chest x‑ray and computed tomography for detection of pulmonary opacities in ED patients: implications for diagnosing pneumonia. Am J Emerg Med 31:401–405
pubmed: 23083885
Eibel R, Herzog P, Dietrich O et al (2006) Pulmonary abnormalities in immunocompromised patients: comparative detection with parallel acquisition MR imaging and thin-section helical CT. Radiology 241:880–891
pubmed: 17032908
Peltola V, Ruuskanen O, Svedstrom E (2008) Magnetic resonance imaging of lung infections in children. Pediatr Radiol 38:1225–1231
pubmed: 18726093
Biederer J, Busse I, Grimm J et al (2002) Sensitivity of MRI in detecting alveolar infiltrates: experimental studies. Rofo 174:1033–1039
pubmed: 12142984
Konietzke P, Mueller J, Wuennemann F et al (2020) The value of chest magnetic resonance imaging compared to chest radiographs with and without additional lung ultrasound in children with complicated pneumonia. PLoS ONE 15:e230252
pubmed: 32191736 pmcid: 7082029
Lutterbey G, Grohe C, Gieseke J et al (2007) Initial experience with lung-MRI at 3.0T: comparison with CT and clinical data in the evaluation of interstitial lung disease activity. Eur J Radiol 61:256–261
pubmed: 17034975
Yi CA, Lee KS, Han J, Chung MP, Chung MJ, Shin KM (2008) 3‑T MRI for differentiating inflammation- and fibrosis-predominant lesions of usual and nonspecific interstitial pneumonia: comparison study with pathologic correlation. Am J Roentgenol 190:878–885
Brady D, Lavelle LP, McEvoy SH et al (2016) Assessing fibrosis in pulmonary sarcoidosis: late-enhanced MRI compared to anatomic HRCT imaging. Qjm 109:257–264
pubmed: 26537956
Craig DA, Colletti PM, Ratto D, Gordonson JS, Raval JK, Sharma OP (1988) MRI findings in pulmonary sarcoidosis. Magn Reson Imaging 6:567–573
pubmed: 3226240
Chung JH, Cox CW, Forssen AV, Biederer J, Puderbach M, Lynch DA (2014) The dark lymph node sign on magnetic resonance imaging: a novel finding in patients with sarcoidosis. J Thorac Imaging 29:125–129
pubmed: 24157619
Stein PD, Fowler SE, Goodman LR et al (2006) Multidetector computed tomography for acute pulmonary embolism. N Engl J Med 354:2317–2327
pubmed: 16738268
Stein PD, Chenevert TL, Fowler SE et al (2010) Gadolinium-enhanced magnetic resonance angiography for pulmonary embolism: a multicenter prospective study (PIOPED III). Ann Intern Med 152:434–443
pubmed: 20368649 pmcid: 3138428
Wucherpfennig L, Triphan SM, Weinheimer O et al (2023) Reproducibility of pulmonary magnetic resonance angiography in adults with muco-obstructive pulmonary disease. Acta Radiol 64:1038–1046
pubmed: 35876445
Ersoy H, Goldhaber SZ, Cai T et al (2007) Time-resolved MR angiography: a primary screening examination of patients with suspected pulmonary embolism and contraindications to administration of iodinated contrast material. AJR Am J Roentgenol 188:1246–1254
pubmed: 17449767
Peacock A, Simonneau G, Rubin L (2006) Controversies, uncertainties and future research on the treatment of chronic thromboembolic pulmonary hypertension. Proc Am Thorac Soc 3:608–614
pubmed: 16963542
Pengo V, Lensing AW, Prins MH et al (2004) Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism. N Engl J Med 350:2257–2264
pubmed: 15163775
Dartevelle P, Fadel E, Mussot S et al (2004) Chronic thromboembolic pulmonary hypertension. Eur Respir J 23:637–648
pubmed: 15083767
Kreitner KF, Ley S, Kauczor HU et al (2004) Chronic thromboembolic pulmonary hypertension: pre- and postoperative assessment with breath-hold MR imaging techniques. Radiology 232:535–543
pubmed: 15215554
Kluge A, Gerriets T, Lange U, Bachman G (2005) MRI for short-term follow-up of acute pulmonary embolism. Assessment of thrombus appearance and pulmonary perfusion: a feasibility study. Eur Radiol 15:1969–1977
pubmed: 15891888
Ley S, Fink C, Zaporozhan J et al (2005) Value of high spatial and high temporal resolution magnetic resonance angiography for differentiation between idiopathic and thromboembolic pulmonary hypertension: initial results. Eur Radiol 15:2256–2263
pubmed: 16041529
Regier M, Kandel S, Kaul MG et al (2007) Detection of small pulmonary nodules in high-field MR at 3 T: evaluation of different pulse sequences using porcine lung explants. Eur Radiol 17:1341–1351
pubmed: 17013593
Baumann T, Ludwig U, Pache G et al (2008) Detection of pulmonary nodules with move-during-scan magnetic resonance imaging using a free-breathing turbo inversion recovery magnitude sequence. Invest Radiol 43:359–367
pubmed: 18496040
Biederer J, Schoene A, Freitag S, Reuter M, Heller M (2003) Simulated pulmonary nodules implanted in a dedicated porcine chest phantom: sensitivity of MR imaging for detection. Radiology 227:475–483
pubmed: 12649421
Meier-Schroers M, Homsi R, Skowasch D et al (2018) Lung cancer screening with MRI: results of the first screening round. J Cancer Res Clin Oncol 144:117–125
pubmed: 28932985
Ohno Y, Koyama H, Yoshikawa T et al (2017) Standard-, reduced-, and no-dose thin-section radiologic examinations: comparison of capability for nodule detection and nodule type assessment in patients suspected of having pulmonary nodules. Radiology 284:562–573
pubmed: 28263700
Hintze C, Biederer J, Wenz HW, Eberhardt R, Kauczor HU (2006) MRI in staging of lung cancer. Radiologe 46:251–254 (256–259)
pubmed: 16440188
Hintze C, Dinkel J, Biederer J, Heussel CP, Puderbach M (2010) New procedures. Comprehensive staging of lung cancer by MRI. Radiologe 50:699–705
pubmed: 20628723
Biederer J, Reuter M, Both M et al (2002) Analysis of artefacts and detail resolution of lung MRI with breath-hold T1-weighted gradient-echo and T2-weighted fast spin-echo sequences with respiratory triggering. Eur Radiol 12:378–384
pubmed: 11870438
Ohno Y, Adachi S, Motoyama A et al (2001) Multiphase ECG-triggered 3D contrast-enhanced MR angiography: utility for evaluation of hilar and mediastinal invasion of bronchogenic carcinoma. J Magn Reson Imaging 13:215–224
pubmed: 11169827
Pauls S, Mottaghy FM, Schmidt SA et al (2008) Evaluation of lung tumor perfusion by dynamic contrast-enhanced MRI. Magn Reson Imaging 26:1334–1341
pubmed: 18538522
Ohno Y, Koyama H, Takenaka D et al (2008) Dynamic MRI, dynamic multidetector-row computed tomography (MDCT), and coregistered 2‑[fluorine-18]-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/CT: comparative study of capability for management of pulmonary nodules. J Magn Reson Imaging 27:1284–1295
pubmed: 18504748
Ohno Y, Koyama H, Nogami M et al (2007) STIR turbo SE MR imaging vs. coregistered FDG-PET/CT: quantitative and qualitative assessment of N‑stage in non-small-cell lung cancer patients. J Magn Reson Imaging 26:1071–1080
pubmed: 17896365
Ohno Y, Hatabu H, Takenaka D et al (2004) Metastases in mediastinal and hilar lymph nodes in patients with non-small cell lung cancer: quantitative and qualitative assessment with STIR turbo spin-echo MR imaging. Radiology 231:872–879
pubmed: 15163823

Auteurs

Lena Wucherpfennig (L)

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Deutschland.
Translational Lung Research Center Heidelberg (TLRC), Deutsches Zentrum für Lungenforschung (DZL), Im Neuenheimer Feld 130.3, 69120, Heidelberg, Deutschland.
Klinik für Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik am Universitätsklinikum Heidelberg, Röntgenstr. 1, 69126, Heidelberg, Deutschland.

Hans-Ulrich Kauczor (HU)

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Deutschland.
Translational Lung Research Center Heidelberg (TLRC), Deutsches Zentrum für Lungenforschung (DZL), Im Neuenheimer Feld 130.3, 69120, Heidelberg, Deutschland.
Klinik für Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik am Universitätsklinikum Heidelberg, Röntgenstr. 1, 69126, Heidelberg, Deutschland.

Monika Eichinger (M)

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Deutschland.
Translational Lung Research Center Heidelberg (TLRC), Deutsches Zentrum für Lungenforschung (DZL), Im Neuenheimer Feld 130.3, 69120, Heidelberg, Deutschland.
Klinik für Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik am Universitätsklinikum Heidelberg, Röntgenstr. 1, 69126, Heidelberg, Deutschland.

Mark O Wielpütz (MO)

Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 420, 69120, Heidelberg, Deutschland. mark.wielpuetz@med.uni-heidelberg.de.
Translational Lung Research Center Heidelberg (TLRC), Deutsches Zentrum für Lungenforschung (DZL), Im Neuenheimer Feld 130.3, 69120, Heidelberg, Deutschland. mark.wielpuetz@med.uni-heidelberg.de.
Klinik für Diagnostische und Interventionelle Radiologie mit Nuklearmedizin, Thoraxklinik am Universitätsklinikum Heidelberg, Röntgenstr. 1, 69126, Heidelberg, Deutschland. mark.wielpuetz@med.uni-heidelberg.de.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH