Downregulation of circETS1 disrupts Th17/Treg homeostasis by inhibiting
FOXP3
Th17/Treg
circETS1
systemic lupus erythematous
Journal
Lupus
ISSN: 1477-0962
Titre abrégé: Lupus
Pays: England
ID NLM: 9204265
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
medline:
17
11
2023
pubmed:
19
10
2023
entrez:
18
10
2023
Statut:
ppublish
Résumé
Systemic lupus erythematosus (SLE) is an autoimmune disease associated with an imbalance of T helper 17 (Th17) to regulatory T cells (Tregs). However, the underlying mechanism remains unclear. Increasing evidence suggests that circular RNAs play a crucial role in SLE. Although circETS1 was discovered 30 years ago, detailed exploration of its functions remains limited. In this study, we measured the expression levels of circETS1 in peripheral blood mononuclear cells (PBMCs) and CD4
Identifiants
pubmed: 37852297
doi: 10.1177/09612033231207545
doi:
Substances chimiques
Biomarkers
0
Forkhead Transcription Factors
0
FOXP3 protein, human
0
MicroRNAs
0
ETS1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1430-1439Déclaration de conflit d'intérêts
Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.