Increasing the aqueous solubility of the anesthetic propofol through wormlike micelle formation.
Aggregates of propofol
Incorporation into the micellar core and palisade
Propofol as fluorescent probe
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
18
07
2023
revised:
28
09
2023
accepted:
11
10
2023
medline:
20
11
2023
pubmed:
20
10
2023
entrez:
19
10
2023
Statut:
ppublish
Résumé
Propofol, a phenol derivative, is commonly employed as an intravenous anesthetic during clinical procedures, formulated as an oil/water emulsion due to its poor solubility in water. The stability limitations associated with emulsions have prompted research efforts towards developing aqueous formulations of propofol. In this work, we investigate the solubility enhancement of propofol in anionic and cationic surfactants. Our findings reveal that the solubility of propofol can increase significantly, up to 100-fold, depending on the nature of the micellar aggregate, as observed for alkylammonium halogenates CnTAB (for n = 12, 14 and 16), contrasting with the lower solubility with SDS. Interestingly, C
Identifiants
pubmed: 37857185
pii: S0927-7765(23)00470-8
doi: 10.1016/j.colsurfb.2023.113592
pii:
doi:
Substances chimiques
Micelles
0
Propofol
YI7VU623SF
Anesthetics
0
Surface-Active Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113592Informations de copyright
Copyright © 2023 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Fernando Bonin Okasaki reports financial support was provided by Capes - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior- Brazil. Edvaldo Sabadini reports financial support was provided by State of Sao Paulo Research Foundation. Edvaldo Sabadini reports financial support was provided by National Council for Scientific and Technological Development.