Ruptured organosilica nanocapsules immobilized acetylcholinesterase coupled with MnO

Acetylcholinesterase / chemistry Inula / metabolism Nanocapsules / therapeutic use Manganese Compounds Oxides Cholinesterase Inhibitors / pharmacology Alzheimer Disease / drug therapy

Journal

Nanoscale
ISSN: 2040-3372
Titre abrégé: Nanoscale
Pays: England
ID NLM: 101525249

Informations de publication

Date de publication:
09 Nov 2023
Historique:
medline: 10 11 2023
pubmed: 20 10 2023
entrez: 20 10 2023
Statut: epublish

Résumé

Abnormal expression of acetylcholinesterase (AChE) causes Alzheimer's disease (AD). Inhibiting AChE is a common strategy for reducing the degradation of neurotransmitter acetylcholine, in order to treat early-stage AD. Therefore, it is crucial to screen and explore AChE inhibitors which are safer and cause fewer side effects. Our research is focused on establishing a platform of ruptured organosilica nanocapsules (RONs) immobilized AChE coupled with an MnO

Identifiants

DOI: 10.1039/d3nr04025a PMID: 37860933
pubmed: 37860933
doi: 10.1039/d3nr04025a
doi:

Substances chimiques

Acetylcholinesterase EC 3.1.1.7
Nanocapsules 0
Manganese Compounds 0
Oxides 0
Cholinesterase Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

17464-17472

Auteurs

Jia Liu (J)

CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicines of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, P. R. China. shiyp@licp.cas.cn.
University of Chinese Academy of Sciences, Beijing 100049, P. R. China.

Wei Ha (W)

CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicines of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, P. R. China. shiyp@licp.cas.cn.

Eshbakova Komila Alibekovna (EK)

S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Uzbekistan.

Rui Ma (R)

CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicines of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, P. R. China. shiyp@licp.cas.cn.

Yan-Ping Shi (YP)

CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicines of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou 730000, P. R. China. shiyp@licp.cas.cn.
ORCID: 0000-0001-6517-9556

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › Ruptured organosilica nanocapsules immobilized...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Asteraceae › Inula › Ruptured organosilica nanocapsules immobilized...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanocapsules › Ruptured organosilica nanocapsules immobilized...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du manganèse › Ruptured organosilica nanocapsules immobilized...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Ruptured organosilica nanocapsules immobilized...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Ruptured organosilica nanocapsules immobilized...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Ruptured organosilica nanocapsules immobilized...