Long 3'UTRs predispose neurons to inflammation by promoting immunostimulatory double-stranded RNA formation.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
27 10 2023
27 10 2023
Historique:
medline:
1
11
2023
pubmed:
20
10
2023
entrez:
20
10
2023
Statut:
ppublish
Résumé
Loss of RNA homeostasis underlies numerous neurodegenerative and neuroinflammatory diseases. However, the molecular mechanisms that trigger neuroinflammation are poorly understood. Viral double-stranded RNA (dsRNA) triggers innate immune responses when sensed by host pattern recognition receptors (PRRs) present in all cell types. Here, we report that human neurons intrinsically carry exceptionally high levels of immunostimulatory dsRNAs and identify long 3'UTRs as giving rise to neuronal dsRNA structures. We found that the neuron-enriched ELAVL family of genes (
Identifiants
pubmed: 37862432
doi: 10.1126/sciimmunol.adg2979
doi:
Substances chimiques
3' Untranslated Regions
0
RNA, Double-Stranded
0
Receptors, Pattern Recognition
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadg2979Subventions
Organisme : NINDS NIH HHS
ID : R01 NS127802
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS116141
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI171827
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM150778
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI106711
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM145440
Pays : United States