Abnormal Microglial Density and Morphology in the Brain of Cyclooxygenase 2 Knockin Mice.
autism spectrum disorder
cell density
microglia morphology
neurodevelopmental disorders
prostaglandin E2
sex differences
Journal
Neuroscience
ISSN: 1873-7544
Titre abrégé: Neuroscience
Pays: United States
ID NLM: 7605074
Informations de publication
Date de publication:
01 Dec 2023
01 Dec 2023
Historique:
received:
18
08
2023
revised:
12
10
2023
accepted:
13
10
2023
medline:
28
11
2023
pubmed:
21
10
2023
entrez:
20
10
2023
Statut:
ppublish
Résumé
Prostaglandin E2 (PGE2) is a signaling molecule produced by cyclooxygenase-2 (COX-2) that is important in healthy brain development. Anomalies in the COX-2/PGE2 pathway due to genetic or environmental factors have been linked to Autism Spectrum Disorders (ASD). Our previous studies showed that COX-2 deficient (COX-2
Identifiants
pubmed: 37863307
pii: S0306-4522(23)00459-1
doi: 10.1016/j.neuroscience.2023.10.009
pii:
doi:
Substances chimiques
Cyclooxygenase 2
EC 1.14.99.1
Dinoprostone
K7Q1JQR04M
Ptgs2 protein, mouse
EC 1.14.99.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
66-81Informations de copyright
Copyright © 2023 IBRO. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.