Discrete hippocampal projections are differentially regulated by parvalbumin and somatostatin interneurons.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 10 2023
20 10 2023
Historique:
received:
02
08
2022
accepted:
12
10
2023
medline:
2
11
2023
pubmed:
21
10
2023
entrez:
20
10
2023
Statut:
epublish
Résumé
People with schizophrenia show hyperactivity in the ventral hippocampus (vHipp) and we have previously demonstrated distinct behavioral roles for vHipp cell populations. Here, we test the hypothesis that parvalbumin (PV) and somatostatin (SST) interneurons differentially innervate and regulate hippocampal pyramidal neurons based on their projection target. First, we use eGRASP to show that PV-positive interneurons form a similar number of synaptic connections with pyramidal cells regardless of their projection target while SST-positive interneurons preferentially target nucleus accumbens (NAc) projections. To determine if these anatomical differences result in functional changes, we used in vivo opto-electrophysiology to show that SST cells also preferentially regulate the activity of NAc-projecting cells. These results suggest vHipp interneurons differentially regulate that vHipp neurons that project to the medial prefrontal cortex (mPFC) and NAc. Characterization of these cell populations may provide potential molecular targets for the treatment schizophrenia and other psychiatric disorders associated with vHipp dysfunction.
Identifiants
pubmed: 37863893
doi: 10.1038/s41467-023-42484-z
pii: 10.1038/s41467-023-42484-z
pmc: PMC10589277
doi:
Substances chimiques
Parvalbumins
0
Somatostatin
51110-01-1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
6653Subventions
Organisme : NIMH NIH HHS
ID : F31 MH127890
Pays : United States
Informations de copyright
© 2023. Springer Nature Limited.
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