Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
20 10 2023
20 10 2023
Historique:
received:
25
05
2023
accepted:
11
10
2023
medline:
1
11
2023
pubmed:
21
10
2023
entrez:
20
10
2023
Statut:
epublish
Résumé
Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD) and determine the crystal structures of mLDHD in FAD-bound form and in complexes with FAD, Mn
Identifiants
pubmed: 37863926
doi: 10.1038/s41467-023-42456-3
pii: 10.1038/s41467-023-42456-3
pmc: PMC10589216
doi:
Substances chimiques
Lactate Dehydrogenases
EC 1.1.-
Lactic Acid
33X04XA5AT
Hydroxy Acids
0
L-Lactate Dehydrogenase
EC 1.1.1.27
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6638Informations de copyright
© 2023. Springer Nature Limited.
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