Dynamic neural representations of memory and space during human ambulatory navigation.

Humans Temporal Lobe Mental Recall Memory, Episodic Spatial Memory Electrocorticography Hippocampus

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
20 10 2023
Historique:
received: 16 02 2023
accepted: 03 10 2023
medline: 1 11 2023
pubmed: 21 10 2023
entrez: 20 10 2023
Statut: epublish

Résumé

Our ability to recall memories of personal experiences is an essential part of daily life. These episodic memories often involve movement through space and thus require continuous encoding of one's position relative to the surrounding environment. The medial temporal lobe (MTL) is thought to be critically involved, based on studies in freely moving rodents and stationary humans. However, it remains unclear if and how the MTL represents both space and memory especially during physical navigation, given challenges associated with deep brain recordings in humans during movement. We recorded intracranial electroencephalographic (iEEG) activity while participants completed an ambulatory spatial memory task within an immersive virtual reality environment. MTL theta activity was modulated by successful memory retrieval or spatial positions within the environment, depending on dynamically changing behavioral goals. Altogether, these results demonstrate how human MTL oscillations can represent both memory and space in a temporally flexible manner during freely moving navigation.

Identifiants

DOI: 10.1038/s41467-023-42231-4 PMID: 37863929 PMC: PMC10589239
pubmed: 37863929
doi: 10.1038/s41467-023-42231-4
pii: 10.1038/s41467-023-42231-4
pmc: PMC10589239
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6643

Subventions

Organisme : NIMH NIH HHS
ID : F30 MH125534
Pays : United States
Organisme : NINDS NIH HHS
ID : K99 NS126715
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS117838
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS103802
Pays : United States

Informations de copyright

© 2023. Springer Nature Limited.

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Auteurs

Sabrina L L Maoz (SLL)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Medical Scientist Training Program, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.

Matthias Stangl (M)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
ORCID: 0000-0002-3331-0510

Uros Topalovic (U)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
ORCID: 0000-0003-4005-7979

Daniel Batista (D)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.

Sonja Hiller (S)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
ORCID: 0000-0003-3828-8284

Zahra M Aghajan (ZM)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.

Barbara Knowlton (B)

Department of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
ORCID: 0000-0002-1532-5081

John Stern (J)

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Jean-Philippe Langevin (JP)

Neurosurgery Service, Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, 90073, USA.
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
ORCID: 0000-0002-4447-5257

Itzhak Fried (I)

Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA.
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.
Faculty of Medicine, Tel-Aviv University, Tel-Aviv, 69978, Israel.
ORCID: 0000-0002-5962-2678

Dawn Eliashiv (D)

Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA.

Nanthia Suthana (N)

Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, 90095, USA. nanthia@ucla.edu.
Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, 90024, USA. nanthia@ucla.edu.
Department of Psychology, University of California, Los Angeles, Los Angeles, CA, 90095, USA. nanthia@ucla.edu.
Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, 90095, USA. nanthia@ucla.edu.
ORCID: 0000-0002-8796-3277

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Dynamic neural representations of memory and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe temporal › Dynamic neural representations of memory and...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Rappel mnésique › Dynamic neural representations of memory and...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Mémoire épisodique › Dynamic neural representations of memory and...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Mémoire › Mémoire spatiale › Dynamic neural representations of memory and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électrocorticographie › Dynamic neural representations of memory and...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Dynamic neural representations of memory and...