Probing naphthalene diimide and 3-hydroxypropylphosphate as end-conjugating moieties for improved thrombin binding aptamers: Structural and biological effects.

Thrombin / metabolism Anticoagulants / chemistry Imides / pharmacology Naphthalenes / pharmacology G-Quadruplexes Aptamers, Nucleotide / chemistry
3-Hydroxypropylphosphate Anticoagulant activity Biophysical characterization Conjugation G-quadruplex structures Naphthalendiimide Oligodeoxyribonucleotides Serum resistance evaluation Thrombin binding aptamer

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
12 2023
Historique:
received: 04 09 2023
revised: 27 09 2023
accepted: 09 10 2023
medline: 3 11 2023
pubmed: 22 10 2023
entrez: 21 10 2023
Statut: ppublish

Résumé

The limitations associated with the in vivo use of the thrombin binding aptamer (TBA or TBA

Identifiants

DOI: 10.1016/j.bioorg.2023.106917 PMID: 37865055
pubmed: 37865055
pii: S0045-2068(23)00578-3
doi: 10.1016/j.bioorg.2023.106917
pii:
doi:

Substances chimiques

Thrombin EC 3.4.21.5
naphthalenediimide 22291-04-9
Anticoagulants 0
Imides 0
Naphthalenes 0
Aptamers, Nucleotide 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106917

Informations de copyright

Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Claudia Riccardi (C)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

Kévan Pérez de Carvasal (K)

Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.

Chiara Platella (C)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy.

Albert Meyer (A)

Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.

Michael Smietana (M)

Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France.

François Morvan (F)

Institut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 34095 Montpellier, France. Electronic address: francois.morvan@umontpellier.fr.

Daniela Montesarchio (D)

Department of Chemical Sciences, University of Naples Federico II, 80126 Naples, Italy. Electronic address: daniela.montesarchio@unina.it.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Thrombine › Probing naphthalene diimide and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents hématologiques › Anticoagulants › Probing naphthalene diimide and...
questionsmedicales.fr › Composés chimiques organiques › Imides › Probing naphthalene diimide and...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Naphtalènes › Probing naphthalene diimide and...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › G-quadruplexes › Probing naphthalene diimide and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Aptamères nucléotidiques › Probing naphthalene diimide and...